Knipholone Cyclooxanthrone and an Anthraquinone Dimer with Antiplasmodial Activities from the Roots of Kniphofia foliosa.

Citation:
Yenesew A, Abdissa, N., Ndakala A, Induli, M., Akala, H.M., Heydenrich, M., Midiwo, J.O. "Knipholone Cyclooxanthrone and an Anthraquinone Dimer with Antiplasmodial Activities from the Roots of Kniphofia foliosa." Phytochemistry Letters . 2013;6:241-245.

Abstract:

A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-
10,70-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together
with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass
spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquineresistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,70-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 0.12 and 4.07 1.54 mg/ml, respectively.

PreviewAttachmentSize
paper_62_abdissa_phytol-2013.pdf583.62 KB

UoN Websites Search