Four Isoflavanones from the stem bark of Platycelphium voënse.

Citation:
Yenesew A. "Four Isoflavanones from the stem bark of Platycelphium voënse." Phytochemistry Letters . 2012;5:150-154.

Abstract:

From the stem bark of Platycelphium voe¨nse (Leguminosae) four new isoflavanones were isolated and
characterized as (S)-5,7-dihydroxy-20,40-dimethoxy-30-(300-methylbut-200-enyl)-isoflavanone (trivial
name platyisoflavanone A), ()-5,7,20-trihydroxy-40-methoxy-30-(300-methylbut-200-enyl)-isoflavanone
(platyisoflavanone B), 5,7-dihydroxy-40-methoxy-200-(2000-hydroxyisopropyl)-dihydrofurano-[400,500:30,20]-
isoflavanone (platyisoflavanone C) and 5,7,20,300-tetrahydroxy-200,200-dimethyldihydropyrano-[500,600:30,40]-isoflavanone (platyisoflavanone D). In addition, the known isoflavanones, sophoraisoflavanone A and glyasperin F; the isoflavone, formononetin; two flavones, kumatakenin and isokaempferide; as well as two triterpenes, betulin and b-amyrin were identified. The structures were elucidated on the basis of spectroscopic evidence. Platyisoflavanone A showed antibacterial activity against Mycobacterium tuberculosis in the microplate alamar blue assay (MABA) with MIC = 23.7 mM, but also showed cytotoxicity (IC50 = 21.1 mM) in the vero cell test.

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