Cytotoxic and Antioxidant Flemingins G-P from the Leaves of Flemingia grahamiana

Citation:
Yenesew A, Gumula I, Erdélyi M, Patrick. A, J Isaiah Omolo Ndiege PS, Omolo, N, Sunnerhagen P. "Cytotoxic and Antioxidant Flemingins G-P from the Leaves of Flemingia grahamiana." Journal of Natural Products . 2014.

Abstract:

The known flemingins A-C (1-3) and nine new chalcones, named flemingins G-O (4-12), along with deoxyhomoflemingin (13) and emodin (14) were isolated from a leaf extract of Flemingia grahamiana. The isolated chalcones were found to have a geranyl substituent modified into a chromene ring possessing a residual chain, as shown by spectroscopic methods. The leaf extract showed an IC50 value of 5.9 μg/mL in a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The chalcones flemingins A, B, C, G, and H were active in the DPPH radical scavenging assay (ED50 4.4-8.9 μM), while flemingins A and C showed cytotoxicity against MCF-7 human breast cancer cells (IC50 8.9 and 7.6 μM, respectively).

PreviewAttachmentSize
paper_76_ivan_et_al_jnp_2014_77_2060_2067.pdf1.28 MB

UoN Websites Search