Busseihydroquinones A-D from the Roots of Pentas bussei

Citation:
Yenesew A. "Busseihydroquinones A-D from the Roots of Pentas bussei." Journal of Natural Products. 2012;75 :1299-1304.

Abstract:

Four new naphthohydroquinones, named busseihydroquinones A−D (1−4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquineresistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.

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