Busseihydroquinones A-D from the Roots of Pentas bussei

Yenesew A. "Busseihydroquinones A-D from the Roots of Pentas bussei." Journal of Natural Products. 2012;75 :1299-1304.


Four new naphthohydroquinones, named busseihydroquinones A−D (1−4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquineresistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.

paper_57_endale_et_al_j_nat_prod_2012.pdf1.68 MB

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