Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya

Citation:
Muthaura CN, Keriko JM, Mutai C, Yenesew A, Heydenreich M, Atilaw Y, Gathirwa JW, Irungu BN, Derese S. "Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya." The Natural Products Journal. 2017;7(2):144-152.

Abstract:

Description
Background:
In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity.
Objective:
To isolate antiplasmodial compounds from these plant species which could be used marker compounds in the standardization of their extracts as a phytomedicine for malaria.
Methods:
Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy.
Results:
Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed …
Total citations
Cited by 1
2018
Scholar articles
Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya
CN Muthaura, JM Keriko, C Mutai, A Yenesew… - The Natural Products Journal, 2017
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