Antiplasmodial b-hydroxydihydrochalcone from seedpods of Tephrosia elata

Yenesew A. "Antiplasmodial b-hydroxydihydrochalcone from seedpods of Tephrosia elata." Phytochemistry Letters . 2009;2:99-102.


From the seedpods of Tephrosia elata, a new b-hydroxydihydrochalcone named (S)-elatadihydrochalcone
was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether
and deguelin were identified. The structures were determined on the basis of spectroscopic evidence.
The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial
activities. The literature NMR data on b-hydroxydihydrochalcones is reviewed and the identity of some
of the compounds assigned b-hydroxydihydrochalcone skeleton is questioned.

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