The Antiplasmodial and Radical Scavenging Activities of Flavonoids of Erythrina burttii.

Citation:
Yenesew A. "The Antiplasmodial and Radical Scavenging Activities of Flavonoids of Erythrina burttii." Acta Tropica . 2012;123:123-127.

Abstract:

The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against
the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with
IC50 values of 0.97 ± 0.2 and 1.73 ± 0.5 g/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 g/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 M) and free radical scavenging (EC50 ca. 10 M) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% hemosuppression. In the same in vivo test, marginal activities were also
observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina
sacleuxii.

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