Anti-plasmodial Flavonoids from the roots of Erythrina abyssinica.

Yenesew A. "Anti-plasmodial Flavonoids from the roots of Erythrina abyssinica." Phytochemistry. 2004; 65:3029-3032.


The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 ± 1.1 and 5.3 ± 0.7 lg/ml, respectively. From this extract, a new chalcone, 20,3,4,40-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 40,7-dihydroxy-30-methoxy-50-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.

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