8-Methoxyneorautenol and Radical Scavenging flavonoids from Erythrina abyssinica.

Citation:
Yenesew A. "8-Methoxyneorautenol and Radical Scavenging flavonoids from Erythrina abyssinica." Bull. Chem. Soc. Ethiopia . 2009;23:205-210.

Abstract:

A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the
root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and
shinpterocarpin were identified for the first time from the roots of this plant. The structures were determined on the basis of spectroscopic evidence. The new compound showed selective antimicrobial activity against
Trichophyton mentagrophytes. The acetone extract of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the standard quercetin.

KEY WORDS: Erythrina abyssinica, Root bark, Leguminosae, Pterocarpan, 8-Methoxyneorautenol,
Pterocarpenes, 3-Hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene, Erycristagallin, Antimicrobial, Radical scavengers, DPPH

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