Bio

DR. AWORI MARK NELSON

Personal Information

Areas Of Specialization

Cardiothoracic Surgery

Paediatric and Congenital cardiac surgery

Research Interests

Congenital Heart Disease,Surgical Education

Publications


2020

Awori, MN, Mehta NP, Kebba N, Mutie JM.  2020.  Possible impairment of surgical decision making and confounded outcome in Fontan surgery by Nakata Index. African Annals of Thoracic and Cardiovascular Surgery. AbstractWebsite

Since cardiac structuring dimensions inform surgical decisions making, Z-score systematic error impairs surgical decision making and confounds outcome measurement, hence a similar error may affect the Nakata index. In this study, PubMed was searched using the terms: “pulmonary,” “artery,” “size,” “Nakata,” “Fontan,” and “outcome”. Studies that did not describe the outcome of the Fontan procedure and the size of the branch pulmonary arteries were excluded. Outcome measures of interest, in relation to BPA size, included: Operative mortality, Fontan “take-down”, length of ICU stay, pleural effusions and functional capacity. The results revealed that of 116 papers retrieved, 9 were included representing 1,042 patients who underwent the Fontan procedure. Six out of 9 papers representing 645 (61.9%) patients reported that BPA size had no relationship with the outcome of the Fontan procedure; while 2 out of 9 papers representing 366 (35.1%) patients found that BPA size did affect the outcome. One paper representing 31 (3%) patients was unable to find any relationship. All the papers that concluded that there was no relationship labelled normal sized BPAs as small because of a systematic error introduced by the Nakata index. Papers that found a relationship did not use the Nakata index. Thus, Nakata index systematic error may impair surgical decision making and confound outcome measurement in Fontan surgery. In addition, continued use of the Fontan index may have similar implications for other congenital heart lesions.

2019

Awori, MN, khan Mohamed MN, Mohamed AA.  2019.  Utility of the Bidirectional Glenn Shunt. Annals of African Surgery. AbstractWebsite

Background: Congenital heart disease (CHD) is a significant cause of childhood morbidity and mortality worldwide. Bi-directional Glenn Shunts (BDGS) form part of the surgical strategy used to treat CHD; no data exists on BDGS usage in the study locality. Methods: A 7-year retrospective, descriptive study was carried out at the Kenyatta National Hospital in Nairobi, Kenya, between 1 January 2006 and 31 December 2012. Results: Eleven BDGS were performed on 11 patients; 63.6% had tricuspid atresia, 27.3% had double outlet right ventricle and 9.1% had pulmonary atresia with intact ventricular septum.

Conclusion: Further studies are warranted to identify factors contributing to the late performance of BDGS, poor post-operative follow-up and failure to perform FC.

Awori, M, Mehta N, Kebba N, Makori. E.  2019.  Adding Blood to St Thomas Solution Does Not Improve Mortality in Pediatric Cardiac Surgery; A Meta-analysis of a Homogenous Population. Annals of African Surgery. AbstractWebsite

Background: Cardioplegia is the gold standard for providing ideal operating conditions while effecting myocardial protection. Some studies suggest that adding blood to St Thomas cardioplegia solution improves efficacy; this is generally accepted as true. However, the few meta-analyses conducted on children have pooled heterogeneous populations; this raises concern about the validity of their conclusions. Methods: PUBMED, the Cochrane Library and Google Scholar were searched systematically until March 2019 using the search terms “cardioplegia”; “myocardial protection”; “pediatric” “pediatric”; “children”; “infants”; “neonates”. Full text articles were examined if abstracts revealed that the studies possibly contained a blood cardioplegia arm and a crystalloid cardioplegia arm. Studies were included in the meta-analysis if they had a 4:1 blood cardioplegia arm and a St Thomas solution arm. Meta-analysis was performed using Meta-Mar software. Results: The search retrieved 423 articles; 5 were included in the meta-analysis, representing 324 patients. The risk ratio for operative mortality was 0.77(95% CI 0.24–2.5; p=0.66). Little evidence was seen of heterogeneity of the pooled patients. Conclusion: Adding blood to St Thomas cardioplegia solution did not improve in-hospital operative mortality; this may have implications for blood cardioplegia use.

2018

Awori, MN.  2018.  I AM-healing health and happiness. , USA: Kindle direct publish
Awori, M, Mehta N, Mitema F, Kebba N.  2018.  Optimal Use of Z-Scores to Preserve the Pulmonary Valve Annulus During Repair of Tetralogy of Fallot. World Journal for Pediatric and Congenital Heart Surgery. 9(3):285-288.tet_z-score_of_tap_use_-awori-2018.pdf
Awori, M, Mutwiri R, Mutunga W, Jowi S, Peninan K, Mang’usu O.  2018.  Neonatal Ebstein’s Anomaly: Surgical Decision Making. Annals of African Surgery. 15(1):40-43.ebsteins_anomaly-case_report-surgical_decision_making-awori-_2018.pdf

2017

Awori, MN.  2017.  I AM- the meaning of life. , USA: Kindle direct publish
Awori, M, Mohamed A, Mohammed N.  2017.  Systemic Arterial-to-Pulmonary Artery Shunt Utilization. Annals of African Surgery. 14(2):96-98.shunts-sapas-utilisation_at_knh-awori-2017.pdf
Awori, M, Mehta N, Mitema F, Kebba N.  2017.  Optimal Z-Score Use in Surgical Decision-Making in Pulmonary Atresia With Intact Ventricular Septum. World Journal for Pediatric and Congenital Heart Surgery. 8(3):385-388.pa-ivs_optimal_z_score_use_in_decision_making_awori_2017.pdf
Awori, M, Mehta N, Mitema F, Mwangi J, Mjahid H, Oloo P.  2017.  Validation of the Euroscore on Cardiac Surgery Patients in Nairobi. Annals of African Surgery. 14(2):100-103.risk_scores-euroscore_validation_at_knh-awori-2017.pdf
Ojuka, D, Dindi K, Awori M.  2017.  Prevalence of Esophageal Adenocarcinoma. Annals of African Surgery. 14(2):82-85.prevalence_of_esophageal_adenocarcinoma_2017.pdf
Osilli, D, Awori M, Ojuka D.  2017.  Factors In uencing Choice of Inguinal Hernia Repair Technique. Annals of African Surgery. 14(1):3-9.hernia-choice_of_repair_technique-osilli-awori-2017.pdf

2013

Awori, MN.  2013.  Reply to Yurekli et al. European Journal of Cardio-Thoracic Surgery. Advanced access published 24th May 2013(Advanced access published 24th May 2013):1.reply_yurekli_et_al_awori_m_eur_j_cardiothor_2013.pdf
Awori, MN, Leong W, Artrip JH, O'Donnell C.  2013.  Tetralogy of Fallot repair: optimal z-score use for transannular patch insertion. European Journal of Cardio-Thoracic Surgery. 43:483-486. Abstracttetralogy_of_fallot_repair_optimal_z-score_use_for_transannula.pdf

Transannular patching is used to relieve significant pulmonary annular stenosis during tetralogy of Fallot repair. Although recent literature has focused on the deleterious effects of pulmonary regurgitation, inadequate relief of stenosis may increase postoperative mortality and the re-intervention rate. Patching criteria based on pulmonary annular z-scores are ambiguous because of the use of varied z-score data sets. This study aimed to generate data that could be used to optimize z-score use for patch insertion. A retrospective review was made of medical records of patients who had a valve-sparing repair of tetralogy of Fallot between 1 January 2000 and 31 December 2010. In a selected group in which the residual gradient was confined to the pulmonary valve, the post-repair peak pressure gradient was determined by trans-thoracic echocardiography and was correlated with the intra-operative pulmonary valve annulus (PVA) diameter z-score. Regression analysis was used to examine this relationship. Data from 46 patients with valve-sparing repair were reviewed; the median age and median weight were 6.5 months and 6.6 kg, respectively; the 30-day mortality was 2.2%. Analysis of these data implies that 25% of the time, all patients with a PVA z-score of -1.3 would have a PVA gradient ≥30 mmHg. Criteria that recommend a transannular patch insertion only when the PVA diameter z-score is significantly smaller than -1.3 (e.g. -3) may result in a significant number of patients with an unacceptable post-repair PVA gradient.

2011

Awori, MN, Finucane K, Gentles TL.  2011.  Optimal Normative Pediatric Cardiac Structure Dimensions for Clinical Use. World Journal for Pediatric and Congenital Heart Surgery. 2(1):85-89.normative_data_abstract.png

2009

Ogendo, SW, Awori MN, Omondi MA, Mulatya EM, Mugo PW.  2009.  Risk of conjunctival contamination from blood splashes during surgery at the Kenyatta National Hospital, Nairobi. Abstract

To determine the utilisation rate of design specific eye protection by surgeons and to assess the risk of conjunctival contamination with blood splashes during surgery. DESIGN: Cross sectional, observational study. SETTING: The theatre suite of Kenyatta National Hospital, Nairobi SUBJECTS: Surgeons from all specialties operating in the theatre suite. RESULTS: The minority of surgeons, 5.2% utilised protective eye goggles compared to 3.5% of assistants. Prescription eye spectacles were the most common form of eye protection at 41.9 and 20.9% respectively for surgeons and their assistants. The contamination rate for provided protective eye wear was 53.1% with the average number of droplets being 2.48 per procedure for the principal surgeon. The duration of surgery and the use of power tools influenced the contamination rate. CONCLUSIONS: The utilisation rate of design specific protective eye wear is low and with a significant risk of conjunctival contamination, changes in attitudes and practices are needed to increase utilisation

2008

NELSON, DRAWORIMARK.  2008.  Awori MN, Ogendo SW.Rachs-1 system in risk stratification for congenital heart disease surgery outcome.East Afr Med J. 2008 Jan;85(1):36-8.. East Afr Med J. 2008 Jan;85(1):36-8.. : Academic Journals Abstract
BACKGROUND: The Risk Adjustment in Congenital Heart Surgery (RACHS-1) system has been used as a benchmark to compare surgical results in developed countries. Its ability to stratify postoperative mortality risk has been validated in several developed countries, however, this has not been examined in a developing country. OBJECTIVES: To assess the ability of the RACHS-1 system to stratify postoperative mortality risk in a developing country. DESIGN: Retrospective study over a five year period between 1st January 2002 and 31st December 2006. SETTING: Kenyatta National Hospital, a teaching and referral hospital in Nairobi, Kenya. SUBJECTS: Three hundred and seventeen consecutive operations were performed on 313 patients aged between 0.25 and 204 months. RESULTS: Operations were performed in RACHS-1 categories 1, 2, 3 and 4 with hospital mortalities of 2.5%, 16.9%, 29.4% and 50% respectively. The difference in mortality between categories 1 and 2 was significant (p-value of 0.0003), however, the difference in mortality between categories 2 and 3 and categories 3 and 4 was not significant (p-values 0.193 and 0.67 respectively). CONCLUSIONS: The RACHS-1 system did not adequately stratify risk in a low case load setting. The use of the RACHS-1 method as a benchmark to compare surgical results of paediatric cardiac surgery services in developing countries may be limited.

2007

NELSON, DRAWORIMARK.  2007.  Awori MN, Ogendo SW, Gitome SW, Ong'uti SK, Obonyo NG.Management pathway for congenital heart disease at Kenyatta National Hospital, Nairobi.East Afr Med J. 2007 Jul;84(7):312-7.. East Afr Med J. 2007 Jul;84(7):312-7.. : Academic Journals Abstract

BACKGROUND: Congenital heart disease (CHD) is a significant cause of death amongst infants. The timing of treatment in relation to the natural history of the disease correlates with the treatment outcome. OBJECTIVES: To determine the age at first suspicion of CHD, the age at confirmation of the diagnosis of CHD and the percentage follow-up at the first post diagnosis out patient clinic and to determine the influence of patient's sex, parental income and parental education have on the MP. DESIGN: A five year retrospective study. SETTING: Kenyatta National Hospital between January 1st 2000 and December 31st 2004. SUBJECTS: Two hundred and fourteen patients were studied. RESULTS: The overall mean age at referral to a paediatric cardiologist was 16.9 +/- 24.4 months [n = 102]. The mean age at which CHD was confirmed by echocardiography was 18.6 +/- 25.6 months [n = 202]. The mean age at which CHD was first suspected in patients from the province with the highest parental income was 9.5 +/- 5.1 months [n = 6]. The mean age at which CHD was first suspected in patients from a province with a significantly lower parent income was 19.1 +/- 23.2 months [n = 22], (p = 0. 046). The mean age at which CHD was confirmed in referred male patients was 16.0 +/- 17.6 months [n=48] and the mean age at which CHD was confirmed in referred female patients was 18.8 +/- 21.7 months [n = 52] (p = 0.25). CONCLUSION: The mean age at referral to a paediatric cardiologist was 16.9 months. This suggests that a significant number of patients may miss the opportunity to have optimal surgical intervention. Parental income appears to influence the MP, however, the level of parental education and patient sex did not.

2005

NELSON, DRAWORIMARK.  2005.  Awori MN, Jani PG.Surgical implications of abdominal pain in patients presenting to the Kenyatta National Hospital casualty department with abdominal pain.East Afr Med J. 2005 Jun;82(6):307-10.. East Afr Med J. 2005 Jun;82(6):307-10.. : Academic Journals Abstract
OBJECTIVE: To determine the local aetiological spectrum of surgically relevant causes of abdominal pain. DESIGN: A prospective descriptive study was carried out. SETTING: Kenyatta National Hospital, Nairobi, Kenya during the month of October 2002. SUBJECTS: Patients aged 13 years and older presenting to the casualty department with abdominal pain were followed through the hospital system to determine whether they would undergo laparotomy and, in those cases who underwent laparotomy, to determine the nature of the pathology found at laparatomy. RESULTS: Abdominal pain was a presenting complaint in 1557 (16.7%) of patients presenting to the casualty department during the study period. Abdominal pain accounted for 17.9% (398 out of 2225 patients) of all admissions via the casualty department. Laparotomy was performed on 68 (4.4%) of patients who presented with abdominal pain to the casualty department. In female patients presenting with abdominal pain, the incidence of ectopic pregnancy and acute appendicitis was 65.3% and 16.3% respectively. The incidence of neoplasia found at laparatomy, for abdominal pain, on patients admitted to the general surgical ward was 3.0%. The incidence of neoplasia, as a cause of abdominal pain resulting in laparatomy was 3.3%. CONCLUSION: The results highlight the fact, with respects to abdominal pain, that there are significant differences between the disease patterns in different geographical locations. Assuming the converse could adversely affect the management of patients with abdominal pain locally.

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