Publications

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2020
Ogonda LA, Muge EK, Wamalwa BM, Mulaa FJ, Tellier C. "Characterization of Crude Cellulases From a Bacillus Sp. Isolated From Lake Bogoria, Kenya.". 2020. Abstract
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Jekayinoluwa T, Tripathi JN, Obiero G, Muge E, Dale J, Tripathi L. "Developing Plantain for Resistance to Banana Aphids by RNA Interference." Multidisciplinary Digital Publishing Institute Proceedings. 2020;36:54. Abstract
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Mosenda E, Chemining'wa G, Ambuko J, Owino W. "Effect of Water Stress on Growth and Yield Components of Selected Spider Plant Accessions." Journal of Medicinally Active Plants. 2020;9:81-97. Abstract
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Mwangi WE. "Epidural Lidocaine and Medetomidine-Ketamine Anaesthesia in Feline Orthopaedic Surgery." International journal of veterinary sciences. 2020;9:164-167. Abstract
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Bundi A, Mburu J, Mbogoh SG, Ambuko JL. "Factors influencing the adoption of pre-harvest practices among mango farmers in Embu and Machakos counties, Kenya." International Journal of Postharvest Technology and Innovation. 2020;7:56-72. Abstract
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Lachenmeier DW, Teipel J, Scharinger A, Kuballa T, Walch SG, Grosch F, Bunzel M, Okaru AO, Schwarz S. "Fully automated identification of coffee species and simultaneous quantification of furfuryl alcohol using NMR spectroscopy." Journal of AOAC International. 2020;103:306-314. Abstract
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Gyang PJ, Muge EK, Nyaboga EN. "Genetic Diversity and Population Structure of Kenyan Common Bean (Phaseolus vulgaris L.) Germplasm Using Peroxidase Gene Markers." Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2020;90:293-301. Abstract
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Achwoka D, Oyugi JO, Mutave R, Munywoki P, Achia T, Akolo M, Muriuki F, Muthui M, Kimani J. "High prevalence of non-communicable diseases among key populations enrolled at a large HIV prevention & treatment program in Kenya." Plos one. 2020;15:e0235606. Abstract
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Wambugu JW, Kyalo D, Mbugua J, Mutave R. "Influence of Access to Quality Services on Performance of Family Planning Programs in Kuresoi North Sub-County, Nakuru County, Kenya." European Journal of Business and Management Research. 2020;5. Abstract
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Wambugu JW, KYALO DOROTHYNDUNGE, Mbugua J, Mutave R. "Influence of Quality Counseling on Performance of Family Planning Programs in Kuresoi North Sub-County, Nakuru County, Kenya." American Journal of Applied Psychology. 2020;9:88-98. Abstract
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Ndeke AN, Mutembei HM, Kaingu CK, Muthee JK. "International Journal of Veterinary Science.". 2020. Abstract
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Nambati EA, Njoka M, Eyase F, Majanja J, Njuguna N, Gitonga SM, Mwikwabe N, Lelo E, Mwangi M, kingoro A, Kimani F, Lubano K, Bulimo W. "Multidisciplinary approach towards training of the next generation of forensic DNA analysts in Africa; a Kenyan perspective." Forensic Science International: Synergy. 2020;2:123-125. Abstract
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Kivata MW, Mbuchi M, Eyase F, Bulimo WD, Kyanya CK, Oundo V, Mbinda WM, Sang W, Andagalu B, Soge OO, McClelland RS, Distelhorst J. "Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya." BMC Infectious Diseases. 2020;20. Abstract
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Abuga KO, Ndwigah SN, Amugune BK, Ongarora DB, Njogu PM, Okaru AO, Kibwage IO. "Quality control report of drugs analyzed in the drug analysis and research unit during the period 2011-2015." East and Central African Journal of Pharmaceutical Sciences. 2020;23:79-86. Abstract
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Mujuka E, Mburu J, Ogutu A, Ambuko J. "Returns to investment in postharvest loss reduction technologies among mango farmers in Embu County, Kenya." Food and Energy Security. 2020;9:e195. Abstract
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Jekayinoluwa T, Tripathi L, Tripathi JN, Ntui VO, Obiero G, Muge E, Dale J. "RNAi technology for management of banana bunchy top disease." Food and Energy Security. 2020;9:e247. Abstract
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Gichure M, Kitala P, Kihurani D, Mande J, Munene N. "Sero-prevalence and risk factors of African Horse Sickness among donkeys in a highland area of Kenya." Journal of Veterinary Medicine and Animal Health. 2020;12:125-131. Abstract
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Cosmas K, Kenichi A. "Utilization of FPGA for Onboard Inference of Landmark Localization in CNN-Based Spacecraft Pose Estimation." Aerospace. 2020;7. AbstractWebsite

In the recent past, research on the utilization of deep learning algorithms for space applications has been widespread. One of the areas where such algorithms are gaining attention is in spacecraft pose estimation, which is a fundamental requirement in many spacecraft rendezvous and navigation operations. Nevertheless, the application of such algorithms in space operations faces unique challenges compared to application in terrestrial operations. In the latter, they are facilitated by powerful computers, servers, and shared resources, such as cloud services. However, these resources are limited in space environment and spacecrafts. Hence, to take advantage of these algorithms, an on-board inferencing that is power- and cost-effective is required. This paper investigates the use of a hybrid Field Programmable Gate Array (FPGA) and Systems-on-Chip (SoC) device for efficient onboard inferencing of the Convolutional Neural Network (CNN) part of such pose estimation methods. In this study, Xilinx’s Zynq UltraScale+ MPSoC device is used and proposed as an effective onboard-inferencing solution. The performance of the onboard and computer inferencing is compared, and the effectiveness of the hybrid FPGA-CPU architecture is verified. The FPGA-based inference has comparable accuracy to the PC-based inference with an average RMS error difference of less than 0.55. Two CNN models that are based on encoder-decoder architecture have been investigated in this study and three approaches demonstrated for landmarks localization.

Okaru AO, Scharinger A, de Rezende TR, Teipel J, Kuballa T, Walch SG, Lachenmeier DW. "Validation of a quantitative proton nuclear magnetic resonance spectroscopic screening method for coffee quality and authenticity (NMR Coffee Screener)." Foods. 2020;9:47. Abstract
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Tembe K, Lagat S, Ambuko J, Chemining'wa G, Owino W. "Variation in Morphological and Agronomic Traits of Selected African Eggplant Accessions.". 2020. Abstract
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McGuire E, Ambuko J, Jarman A, Mitcham E. "Who Is Fortunate Enough to Eat All Their Fruits and Veggies?". In: 2020 ASHS Annual Conference. ASHS; 2020. Abstract
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2019
F.M M, D.O M, Gitau. A.N. "Modelling and Prediction of Drying Kinetics in a Hybrid Solar Desiccant Drier.". In: Kenya Society of Environmental, Biological and Agricultural Engineers Annual Conference. Nairobi, Kenya; 2019.
Ntwiga DB. "Fintech and Banks Collaboration: Does it Influence Efficiency inthe Banking Sector?". In: Kenya Bankers Association 8th Banking Research Conference. Radisson Blu Hotel Nairobi Kenya; 2019. Abstract

The efficiency of the banking sector in Sub-Saharan Africa is low compared to rest of the world and Fintech is taunted to alter this scenario. Efficient banks increase financial stability, intermediation and value to the shareholders. As Fintech innovations continue to alter the landscape in the banking sector, banks in Kenya are forming collaborations that are envisioned to shape the evolution of credit allocation and delivery of services. The study investigates the influence of Fintech on a bank’s efficiency in credit allocation using thedata envelopment model with input-orientation based on the intermediationdimension. Efficiency scores are decomposed as technical efficiency, pure technical efficiency and scale efficiency.Secondary data for the period 2009-2018 is extracted from thirteen banks sampled from the top fifteen banks in Kenya based on their market share. The banks are either locally owned or listed in Nairobi Securities Exchange, of which five have Fintech collaborationswith a Pre-Fintech and Post Fintechperiod. Panel regression model tested the effect of financial ratios on technical efficiency of the banks. Fintech collaborating banks are more technically efficient based on models M1, M2 and M3 in Pre-Fintech. In Post Fintech, the Fintech banks are more efficient based on models M2, M3 and M4 but with decreasing returns to scale which is due to the banks being overly large, thus non-optimal in their operations. The positive effect on technical efficiency is observed from the ratios, liquidity, loan intensity, return on assets and cost of income. Cost of intermediation and credit risk had a negative effect on technical efficiency. Therefore, Fintech and banks collaborations did not significantly influence efficiency in the banking sector.

Ondiba IM, Oyieke FA, Athinya DK, Nyamongo IK, Estambale BBA. "Larval species diversity, seasonal occurrence and larval habitat preference of mosquitoestransmitting Rift Valley fever and malariain Baringo County, Kenya.". In: C.B.P.S. Annual conference.; 2019.
M. KD, M. MI. "Strain level metagenomic analysis of Nairobi Market fermented camel milk.". In: University of Nairobi, AGRO2019 conference and Exhibition. FOA,CAVS-University of Nairobi; 2019.
Ogutu K. "High Court chose safe route in gay sex case." The Standard, May 28, 2019.
Oredo J, Njihia J, Iraki XN. "Institutional Pressures and Cloud Computing Adoption.". In: IST-Africa 2019 . Nairobi; 2019.
Kiriinya LK, GATARI MJ. "Isotope Tracing Application in Source Identification of Tropospheric Black Carbon in Sub-Saharan Africa.". In: International Conference on Tracers and Tracing Methods. VIETNAM; 2019.
Sila MJ, Nyambura MI, Abong’o DA, Mwaura FB, Iwuoha E. "Biosynthesis of Silver Nanoparticles from Eucalyptus Corymbia Leaf Extract at Optimized Conditions.". In: Nano Hybrids and Composites Vol. 25. Vol. 25. South Africa; 2019:. Abstract

Abstract:

This study reports the biosynthesis of narrow range diameter silver nanoparticles at optimum conditions using Eucalyptus corymbia as a reducing and stabilizing agent. Optimal conditions for biosynthesis of silver nanoparticles (AgNPs) were found to be; an extraction temperature of 90°C, pH of 5.7 a Silver Nitrate concentration of 1mM and AgNO3 to plant extract ratio of 4:1. UV-Visible spectroscopy monitored the formation of colloidal AgNPs. The UV-Visible spectrum showed a peak around 425 nm corresponding to the Plasmon absorbance of the AgNPs. The size and shape characterization of the AgNPs was done using Transmission Electron Microscopy (TEM) techniques which revealed narrow range diameter (18-20 nm), almost monodispersed AgNPs, spherical in nature and with minimal agglomeration. Energy Dispersive X-ray (EDX) results showed the presence of two peaks at 3.0 and 3.15 keV in the silver region. The Fourier Transform Infrared-Spectra (FTIR) of the plant extract and the AgNPs gave rise to vibrational peaks at 3260 and 1634 wavenumbers which are due to the presence of OH and –C=C-functional groups respectively.

Wasamba P. "Hasty varsity mergers could mess up things." The Standard, July 9, 2019:15.
‘Writing and Publishing: My Personal Experience’. Nairobi: University of Nairobi; 2019.
"Nafasi ya Kiswahili katika Elimu na Maendeleo.". In: CHAKAMA. Maasai Mara University; 2019.
MWANGI IK, Muketha SM. "Deriving Value Chain Model Applications in Planning From Skills Audit In Rwandan Urbanization Sector. Presented at 2019 Annual National Planners Convention.". In: Annual National Planners Convention. Organized by the Kenya Institute of Planners (KIP). Diana Reef Beach Resort and Spa, Kwale, Kenya; 2019.
Gichuyia LN. "INDOOR OVERHEATING RISK ANALYSIS OF OFFICE BUILDINGS IN NAI- ROBI IN A CHANGING CLIMATE.". In: Annual Eastern Africa Architecture Workshop and Exhibition. ADD Building - University of Nairobi; 2019.
Gichuyia LN. "LESSONS LEARNT FROM THERMAL DATA-LOGGING OF BUILDINGS IN NAIROBI OVER THE YEARS; HIGHLIGHT- ING THE DEMAND FUNCTIONS FOR DECI- SION-SUPPORT.". In: Annual Eastern Africa Architecture Workshop and Exhibition. ADD Building - University of Nairobi; 2019.
Ralwala AO. "Architectural metabletica : Luo existence in informal settlements.". In: Tropical Architecture and the Urban Challenges facing the Global South. Sub-theme: Socio-cultural issues. 9TH Eastern Africa Architecture Workshop, University of Nairobi’s Department of Architecture 4th-5th September 2019.; 2019.
Ralwala AO. "Architectural metabletica : Transformation of the Kenyan Luo dwelling unit.". In: Tropical Architecture and the Urban Challenges facing the Global South. Sub-theme: Socio-cultural issues. 9TH Eastern Africa Architecture Workshop, University of Nairobi’s Department of Architecture 4th-5th September 2019.; 2019.
N NB, O OT, O KD, N MJ. "Exploring the Possible Use of EN 197 CEM II/B-P and CEM IV/B-P in the Production of High-Performance Concrete.". In: IEK-EBK Conference. Diani, Kenya; 2019.
Dulo. "Onset and Cessation of Rainfall in East Africa.". In: NBCBN training Workshop. Dar es Salaam University; 2019.
Karimurio J, Gichuhi S, Nyamori J, Gachago M, Rono H, Gichangi M, Mwangi A, Kefa R. "Is task-shifting of screening for diabetic retinopathy (DR) from eye specialists to technicians accurate?". In: East African Community East African Health Research Commission 7th East African Health and Scientific Conference. Dar es Salaam; 2019.invitation_letter_7th_eahsc_pg1_jefitha_karimurio1.pdfuse_of_technology_to_taskshift__prof_jefitha_karimurio.pdf
Mbuge DO. "How can we generate money from lost and wasted food? .". In: Frontiers of Engineering for Development symposium: From Feeding People to Nourishing People. Antananarivo, Madagascar; 2019.
Kanoti J, Olago D, Opiyo N, Nyamai C, Dulo SI, Taylor R. "Characterisation of geogenic controls on groundwater quality in a volcano-sedimentary aquifer in Kenya using graphical and statistical methods.". In: 46th IAH Congress. Malaga, Spain; 2019. Abstractcontribution.pdf

Geogenic controls on groundwater quality are often dominant but remain inadequately characterized for many aquifer systems. The volcano-sedimentary aquifer of Kisumu (Kenya) is used widely to provide safe water to the informal settlements and acts as a strategic, supplementary supply to the city during interruptions in service from the main piped water supply network drawing from Lake Victoria. Little is known, however, of the geogenic controls on groundwater quality in the Kisumu aquifer. We characterize the origin and composition of solutes in groundwaters sampled from the Kisumu aquifer using a range of techniques. Classical graphical methods (i.e. Durov, Piper, Schoeller, Stiff and Ternary plots) were used as interpretative tools of the main hydrogeochemical processes whereas principal component analysis (PCA) and hierarchical cluster analysis (HCA) methods were used to assess hydrochemical variations and water types. An agglomeration schedule with five cluster solutions and between-groups linkage method of clustering using the squared Euclidian distance was employed. Variables were standardized to z-scores so that each variable contributed equally to the clusters. The study identifies three main groundwater geochemical signatures in the Kisumu study area: cation exchange (Ca-Na, Ca-Mg) between aqueous and solid phases, the chemistry of recharge water, and groundwater mixing. The concentration of major ions in groundwater varies with geology and also seasonally. The dominant water facies is Na-Ca-HCO3 type; other hydrochemical facies include Ca-Mg-HCO3 and Na-HCO3. Hydrochemical plots suggest that dissolution of carbonates and halite are the other major chemical processes, in addition to cation exchange, that control the groundwater chemistry in the Kisumu aquifer. Hierarchical cluster analysis of the main cations and anions discriminated satisfactorily the various water types in the study area.

MWANGI IK. "Making Devolution and Decentralization Work n Kiambu through Institutional Framework of Boards of Municipalities.". In: Training Workshop for Capacity Building for Boards of Municipalities. Organized by Kiambu County Government and Kenya Urban Support Programme (KUSP). Lake Naivasha Resort, Naivasha; 2019.
Muricho DN, Otieno DJ, Oluoch-Kosura, Jistrom M. "Building on local pastoralists’ knowledge for effective management of the arid and semi-arid areas.". In: 20th Annual World Bank Conference on Land and Poverty. Washington DC, USA; 2019.
Ruto LC, Otieno DJ, Oluoch-Kosura W, Mureithi S, Nyberg G. "Emerging forms of land market participation and implications on pastoralists’ livelihoods in Kenya.". In: 20th Annual World Bank Conference on Land and Poverty. Washington DC, USA; 2019.
Onikeku O, Shitote SM, Mwero JN, Adedeji AA. "Comparative Analysis of Compressive Strength of Bamboo Leaf Ash and Bagasse Ash Concretes.". In: Machakos University 2nd Annual International Conference. Machakos, Kenya; 2019.
Gitao, C.G., Toroitich, K, Khalif, Field, C, Wario, S. Mass Livestock Deaths In EL-HADI Of North-Horr Sub-County, MARSABIT COUNTY. Nairobi: RPLP; 2019.marsabit_camel_deaths-paper_-1.docx
omari HK, Kayeli E. "Comprehensive sex education in Kenya: Islamic perspective.". In: THE 2ND ANNUAL INTERNATIONAL CONFERENCE MACHAKOS UNIVERSITY, KENYA. machakos university; 2019.
Oredo J. "Personal Cloud Computing Adoption: The Effect of Individual IT Mindfulness.". In:  African International Business Management (AIBUMA) Conference . Nairobi; 2019.
Gitao C. "Role of Academia and Researchers in the Agricultural sector in Kenya’.". In: Kenya Private Sector Agricultural sector. Intercontinental Hotel, Nairobi; 2019.
Akach JA. "Unearth tourism assets through co-design: Creative methods to engage the youth .". In: 2nd Annual Architecture and Engineering Conference. University of Nairobi; 2019.
Gichuyia LN. "THE IMPACT OF CLIMATE CHANGE ON THE INDOOR OVERHEATING RISK LANDSCAPE OF NAIROB.". In: In Proceedings of the Annual Architecture and Engineering Conference - Business opportunities in Energy, Manufacturing, Infrastructural and Environmental Research. School of Engineering, University of Nairobi, Kenya; 2019.
Kimani MD, G.N K, R.N O, Muhammenda. "Simulating Maize (Zea Mays L.) performance using Aquacrop Model under Varying Irrigation Schedules and Water Depletion Levels in Bura Irrigation Scheme, Kenya.". In: AGRO 2019 Conference & Exhibition. College of Agriculture and Veterinary Science.; 2019.
Wachira K. "A Quasi-Flipped Learning Model For Teaching the Raspberry Pi.". In: AEC 2019. Nairobi, Kenya; 2019.
Wasamba P. "Will public service commission Succeed in appointing VCs competatively." The Standard, February 22, 2019:14.
Cosmas K, Kenich A. "Implementation of Machine Learning Methods on FPGA for Onboard Satellite Operation.". In: 70th International Astronautical Congress (IAC). Washington DC, USA; 2019.
Nancy M, Birech Z, Kaduki K. "Application of butterfly wing iridescence, reflection spectroscopy, and chemometric tools in adulteration sensing in gasoline.". In: FiO/Laser Science (pp. JTu4A-13). Washington DC; 2019.
Arunga S, Kintoki GM, Gichuhi S, Onyango J, Ayebazibwe B, Newton R, Leck A, Macleod D, Hu VH, Burton MJ. "Risk Factors of Microbial Keratitis in Uganda: A Case Control Study." Ophthalmic Epidemiol. 2019:1-7. AbstractWebsite

Purpose: Microbial keratitis (MK), is a frequent cause of sight loss worldwide, particularly in low and middle-income countries. This study aimed to investigate the risk factors of MK in Uganda.
Methods: Using a nested case control, we recruited healthy community controls for patients presenting with MK at the two main eye units in Southern Uganda between December 2016 and March 2018. Controls were individually matched for age, gender and village of the cases on a 1:1 ratio. We collected information on demographics, occupation, HIV and Diabetes Mellitus status. In STATA version 14.1, multivariable conditional logistic regression was used to generate odds ratios for risk factors of MK and a likelihood ratio test used to assess statistical significance of associations.
Results: Two hundred and fifteen case-control pairs were enrolled. The HIV positive patients among the cases was 9% versus 1% among the controls, = .0003. Diabetes 7% among the cases versus 1.4% among the controls, = .012. Eye trauma was 29% versus 0% among the cases and controls. In the multivariable model adjusted for age, sex and village, HIV (OR 83.5, 95%CI 2.01-3456, = .020), Diabetes (OR 9.38, 95% CI 1.48-59.3, = .017) and a farming occupation (OR 2.60, 95%CI 1.21-5.57, = .014) were associated with MK. Compared to a low socio-economic status, a middle status was less likely to be associated with MK (OR 0.29, 95%CI 0.09-0.89, < .0001).
Conclusion: MK was associated with HIV, Diabetes, being poor and farming as the main occupation. More studies are needed to explore how these factors predispose to MK.

Peter SG, Gakuya DW, Maingi N, Mulei CM. "Prevalence and risk factors associated with infections in smallholder dairy cattle in Nairobi City County, Kenya." Vet World. 2019;12(10):1599-1607. Abstract

Ehrlichiosis caused by is a tick-borne disease of great economic importance in cattle production worldwide. Despite its economic impact, limited knowledge is available on its epidemiology in Africa, including Kenya. Suspected cases of infections have been reported in the recent past to the University of Nairobi's Veterinary Hospital, prompting the need to investigate their possible re-emergence. Therefore, this study was aimed at determining the prevalence of among smallholder dairy cattle in Nairobi City County and to assess potential risk factors. This knowledge may guide the development of appropriate control strategies of ehrlichiosis, subsequently reducing associated losses.

Arunga S, Kintoki GM, Gichuhi S, Onyango J, Newton R, Leck A, Macleod D, Hu VH, Burton MJ. "Delay Along the Care Seeking Journey of Patients with Microbial Keratitis in Uganda." Ophthalmic Epidemiol. 2019:1-10. AbstractWebsite

PURPOSE:To describe the care seeking journey and causes of delay among patients with Microbial Keratitis in Uganda.
METHODS:A prospective cohort of patients presenting with microbial keratitis at the two main eye units in Southern Uganda (2016-2018). We collected information on demographics, home address, clinical history, and presentation pathway including, order of facilities where patients went to seek care, treatment advice, cost of care, and use of Traditional Eye Medicine. Presentation time was noted. We compared "direct" presenters versus "indirect" presenters and analysed predictors of delay.
RESULTS: About 313 patients were enrolled. All were self-referred. Only 19% of the patients presented directly to the eye hospital. Majority (52%) visited one facility before presenting, 19% visited two facilities, 9% visited three facilities, and 2% visited four facilities. The cost of care increased with increase in the number of facilities visited. People in a large household, further distance from the eye hospital and those who used Traditional Eye Medicine were less likely to come directly to the eye hospital. Visiting another facility prior to the eye hospital and use of Traditional Eye Medicine aOR 1.58 (95%CI 1.03-2.43), p = .038 were associated with delayed presentation to the eye hospital.
CONCLUSION: This study provided information on patient journeys to seek care. Delay was largely attributable to having visited another health facility: a referral mechanism for microbial keratitis was non-existent. There is need to explore how these health system gaps can be strengthened.

Ampt FH, Lim MSC, Agius PA, Chersich MF, Manguro G, Gichuki CM, Stoové M, Temmerman M, Jaoko W, Hellard M, Gichangi P, Luchters S. "Use of long-acting reversible contraception in a cluster-random sample of female sex workers in Kenya." Int J Gynaecol Obstet. 2019. Abstract

To assess correlates of long-acting reversible contraceptive (LARC) use, and explore patterns of LARC use among female sex workers (FSWs) in Kenya.

Bore M, Choudhari N, Chaurasia S. "Management of complications of cosmetic iris implants in a phakic eye: a case report and literature review." Int Ophthalmol. 2019;39(5):1141-1146. Abstract

To report the intricacies of managing complications that arose out of cosmetic iris implants (BrightOcular) placement.

Karthik S, Djukic T, Kim J-D, Zuber B, Makanya A, Odriozola A, Hlushchuk R, Filipovic N, Jin SW, Djonov V. "Publisher Correction: Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development." Sci Rep. 2019;9(1):4152. Abstract

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Sabo MC, Richardson BA, Lavreys L, Martin HL, Jaoko W, Mandaliya K, Baeten JM, Overbaugh J, McClelland SR. "Does bacterial vaginosis modify the effect of hormonal contraception on HIV seroconversion." AIDS. 2019;33(7):1225-1230. Abstract

A recent study of HIV serodiscordant couples found that depot medroxyprogesterone acetate (DMPA) and oral contraceptive pills (OCPs) were associated with increased HIV risk in the presence, but not in the absence, of bacterial vaginosis. We assessed whether bacterial vaginosis is an effect modifier of the association between hormonal contraception and HIV seroconversion in female sex workers (FSWs) in Mombasa, Kenya.

Mutwedu VB, Ayagirwe RBB, Bacigale SB, Mwema LM, Butseme S, Kashosi T, Mitima B, Manyawu GJ, Nyongesa AW. "Effect of dietary inclusion of small quantities of Mucuna pruriens seed meal on sexual behavior, semen characteristics, and biochemical parameters in rabbit bucks (Oryctolagus cuniculus)." Trop Anim Health Prod. 2019;51(5):1195-1202. Abstract

The aim of this work was to investigate the effects of Mucuna pruriens seed meal (MSM) on sexual behavior, semen, and biochemical parameters in rabbit bucks. Twenty-four 12-week-old rabbit bucks weighing 1002 to 1156 g were randomly allocated to three experimental diets containing 0, 1.5, and 3% of MSM in a 3-month trial. Sexual behavior parameters such as mounting latency, mounting frequency, successful mounting frequency, intromission latency, and post ejaculatory interval were monitored at the end of the experiment by mating with receptive females. Thereafter, rabbits were weighed, stunned, and humanely sacrificed and testes, epididymis, and vas deferens were harvested for evaluation of organ weights and semen characteristics. Results indicate that supplementing rabbit diet with MSM induced a significant decrease (P < 0.05) in mounting latency (69.7%) and intromission latency (19.7%), while it significantly (P < 0.05) increased successful mounting frequency (60%) as well as relative weight of testis (33.3%) and vas deferens (54.5%). There was a dose-dependent increase (P < 0.05) in sperm motility (35.7%) and concentration (65.9%), serum albumin (19.1%) and protein concentration (9.9%), and a decrease in sperm morphological alterations (68.3%), serum cholesterol (13.4%), and urea (11.6%) in treatment groups where MSM was supplemented at 3% compared to controls. From the findings, it appears MSM is a potential enhancer of male reproductive performance that can be recommended to rabbit farmers for improving reproductive performance and quality of semen, hence a boon to reproduction and production in rabbit farming industry.

Dimova I, Karthik S, Makanya A, Hlushchuk R, Semela D, Volarevic V, Djonov V. "SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception." J. Cell. Mol. Med.. 2019;23(6):3916-3926. Abstract

The precise mechanisms of SDF-1 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF-1 and CXCR4. In the current study, we demonstrated SDF-1 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF-1 expression in wild-type mice with normal liver vessel structure. In addition, pharmacological inhibition of SDF-1/CXCR4 signalling by AMD3100 perturbs intussusceptive vascular growth and abolishes mononuclear cell recruitment in the chicken area vasculosa. In contrast, treatment with recombinant SDF-1 protein increased microvascular density by 34% through augmentation of pillar number compared to controls. The number of extravasating mononuclear cells was four times higher after SDF-1 application and two times less after blocking this pathway. Bone marrow-derived mononuclear cells (BMDC) were recruited to vessels in response to elevated expression of SDF-1 in endothelial cells. They participated in formation and stabilization of pillars. The current study is the first report to implicate SDF-1/CXCR4 signalling in intussusceptive angiogenesis and further highlights the stabilizing role of BMDC in the formation of pillars during vascular remodelling.

Lokken EM, Manguro GO, Abdallah A, Ngacha C, Shafi J, Kiarie J, Jaoko W, Srinivasan S, Fiedler TL, Munch MM, Fredricks DN, McClelland SR, Balkus JE. "Association between vaginal washing and detection of by culture and quantitative PCR in HIV-seronegative Kenyan women: a cross-sectional analysis." Sex Transm Infect. 2019. Abstract

Vaginal washing has been associated with reductions in cultivable and an increased risk of both bacterial vaginosis (BV) and HIV infection. The effect of vaginal washing on the quantity of individual species is not well characterised. This analysis tested the hypothesis that vaginal washing would be associated with a lower likelihood of spp. detected by both culture and quantitative PCR (qPCR).

Marangu D, Gray D, Vanker A, Zampoli M. "Exogenous lipoid pneumonia in children: A systematic review." Paediatr Respir Rev. 2019. Abstract

To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

Lokken EM, Richardson BA, John Kinuthia, James N Kiarie, Mwinyikai K, Abdalla A, Jaoko W, Mandaliya K, Shafi J, Scott McClelland R. "A Prospective Cohort Study of the Association Between Body Mass Index and Incident Bacterial Vaginosis." Sex Transm Dis. 2019;46(1):31-36. Abstract

Some studies suggest that higher body mass index is associated with increased susceptibility to bacterial vaginosis (BV), but results are conflicting.

Perciani CT, Farah B, Kaul R, Ostrowski MA, Mahmud SM, Anzala O, Jaoko W, MacDonald KS. "Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation." J. Clin. Invest.. 2019;129(2):875-886. Abstract

Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny, since trials with adenovirus serotype 5-vectored (Ad5-vectored) HIV vaccine demonstrated increased HIV risk in individuals with pre-immunity to the vector that was thought to be associated with mucosal immune activation (IA). Therefore, given the prospect of developing an HIV/VZV chimeric vaccine, it is particularly important to define the impact of VZV vaccination on IA.

Perciani CT, Farah B, Kaul R, Ostrowski MA, Mahmud SM, Anzala O, Jaoko W, MacDonald KS. "Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation." J. Clin. Invest.. 2019;129(2):875-886. Abstract

Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny, since trials with adenovirus serotype 5-vectored (Ad5-vectored) HIV vaccine demonstrated increased HIV risk in individuals with pre-immunity to the vector that was thought to be associated with mucosal immune activation (IA). Therefore, given the prospect of developing an HIV/VZV chimeric vaccine, it is particularly important to define the impact of VZV vaccination on IA.

Amzati GS, Djikeng A, Odongo DO, Nimpaye H, Sibeko KP, Muhigwa J-BB, Madder M, Kirschvink N, Marcotty T. "Genetic and antigenic variation of the bovine tick-borne pathogen Theileria parva in the Great Lakes region of Central Africa." Parasit Vectors. 2019;12(1):588. Abstract

Theileria parva causes East Coast fever (ECF), one of the most economically important tick-borne diseases of cattle in sub-Saharan Africa. A live immunisation approach using the infection and treatment method (ITM) provides a strong long-term strain-restricted immunity. However, it typically induces a tick-transmissible carrier state in cattle and may lead to spread of antigenically distinct parasites. Thus, understanding the genetic composition of T. parva is needed prior to the use of the ITM vaccine in new areas. This study examined the sequence diversity and the evolutionary and biogeographical dynamics of T. parva within the African Great Lakes region to better understand the epidemiology of ECF and to assure vaccine safety. Genetic analyses were performed using sequences of two antigen-coding genes, Tp1 and Tp2, generated among 119 T. parva samples collected from cattle in four agro-ecological zones of DRC and Burundi.

Omondi WP, Owino EA, Odongo D, Mwangangi JM, Torto B, Tchouassi DP. "Differential response to plant- and human-derived odorants in field surveillance of the dengue vector, Aedes aegypti." Acta Trop. 2019;200:105163. Abstract

Linalool oxide (LO) and hexanoic acid (HA) represent plant- and human-derived odorants, respectively, previously found as attractants for the dengue vector Aedes aegypti. Here, we investigated if a blend of both compounds can improve captures of this mosquito species in field trials in two dengue endemic sites, Kilifi and Busia Counties in Kenya. Ae. aegypti captures were significantly higher in Kilifi than Busia (χ = 170.63, P < 0.0001) and varied by treatments (χ = 151.19, P = 0.002). We found that CO-baited BG Sentinel traps combined with a blend of both odorants decreased Ae. aegypti captures about 2- to 4-fold compared to captures with the individual compounds (LO or HA) used as positive controls. This was the case for all blends of LO and HA, irrespective of the doses tested. Our findings indicate that combining plant- and human-derived odors may elicit a masking effect in trapping Ae. aegypti. These results partly corroborate previous findings for malaria mosquitoes which showed that combining lures from both host sources either decreases or increases trap catches depending on the dose. Further investigations in the usefulness of combining plant and animal odorants in mosquito trapping are therefore necessary.

Karuga, SW, MJ G, Kelder EM, JCM M. "Morphological control of thin films: Application of electrospray technique.". In: European Aerosol Conference (EAC) 2019 . Gothenburg, Sweden; 2019.
Cheng C-Y, Wang N, Wong TY, Congdon N, He M, Wang YX, Braithwaite T, Casson RJ, Cicinelli MV, Das A, Flaxman SR, Jonas JB, Keeffe JE, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Bourne RRA, of the of Study VLEGGBD. "Prevalence and causes of vision loss in East Asia in 2015: magnitude, temporal trends and projections." Br J Ophthalmol. 2019. AbstractWebsite

BACKGROUND: To determine the prevalence and causes of blindness and vision impairment (VI) in East Asia in 2015 and to forecast the trend to 2020.
METHODS: Through a systematic literature review and meta-analysis, we estimated prevalence of blindness (presenting visual acuity <3/60 in the better eye), moderate-to-severe vision impairment (MSVI; 3/60≤presenting visual acuity <6/18), mild vision impairment (mild VI: 6/18≤presenting visual acuity <6/12) and uncorrected presbyopia for 1990, 2010, 2015 and 2020. A total of 44 population-based studies were included.
RESULTS: In 2015, age-standardised prevalence of blindness, MSVI, mild VI and uncorrected presbyopia was 0.37% (80% uncertainty interval (UI) 0.12%-0.68%), 3.06% (80% UI 1.35%-5.16%) and 2.65% (80% UI 0.92%-4.91%), 32.91% (80% UI 18.72%-48.47%), respectively, in East Asia. Cataract was the leading cause of blindness (43.6%), followed by uncorrected refractive error (12.9%), glaucoma, age-related macular degeneration, corneal diseases, trachoma and diabetic retinopathy (DR). The leading cause for MSVI was uncorrected refractive error, followed by cataract, age-related macular degeneration, glaucoma, corneal disease, trachoma and DR. The burden of VI due to uncorrected refractive error, cataracts, glaucoma and DR has continued to rise over the decades reported.
CONCLUSIONS:Addressing the public healthcare barriers for cataract and uncorrected refractive error can help eliminate almost 57% of all blindness cases in this region. Therefore, public healthcare efforts should be focused on effective screening and effective patient education, with access to high-quality healthcare.

Rono H, Bastawrous A, Macleod D, Wanjala E, Gichuhi S, Burton M. "Peek Community Eye Health - mHealth system to increase access and efficiency of eye health services in Trans Nzoia County, Kenya: study protocol for a cluster randomised controlled trial." Trials. 2019;20(1):502. AbstractWebsite

Globally, eye care provision is currently insufficient to meet the requirement for eye care services. Lack of access and awareness are key barriers to specialist services; in addition, specialist services are over-utilised by people with conditions that could be managed in the community or primary care. In combination, these lead to a large unmet need for eye health provision. We have developed a validated smartphone-based screening algorithm (Peek Community Screening App). The application (App) is part of the Peek Community Eye Health system (Peek CEH) that enables Community Volunteers (CV) to make referral decisions about patients with eye problems. It generates referrals, automated short messages service (SMS) notifications to patients or guardians and has a program dashboard for visualising service delivery. We hypothesise that a greater proportion of people with eye problems will be identified using the Peek CEH system and that there will be increased uptake of referrals, compared to those identified and referred using the current community screening approaches.

Hassan S, Skilton RA, Pelle R, Odongo D, Bishop RP, Ahmed J, Seitzer U, Bakheit M, HASSAN SM, El Hussein AM. "Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods." Prev Vet Med. 2019;169:104697. Abstract

Malignant theileriosis of sheep and goats caused by Theileria lestoquardi is considered to be among the most important tick borne diseases in the Sudan. Information on the prevalence of the disease in different parts of the Sudan is limited. The purpose of this study was to estimate the prevalence of the disease in five states of the Sudan using molecular and serological assays. A total of 393 blood and serum samples from clinically asymptomatic sheep were analysed using nested reverse line blot (nRLB) and loop mediated isothermal amplification (LAMP), as well as an enzyme-linked immunosorbent assay (ELISA). The results indicated a sero-prevalence of 33.8% while RLB and LAMP assays revealed molecular prevalences of 29.5 and 22.6% respectively. The prevalence of Theileria lestoquardi varied significantly according to the geographical origin of the infected animals, whereas age and gender did not have a significant effect. RLB data indicated that T. lestoquardi usually occurred as a co-infection with the non-pathogenic Theileria ovis. Using RLB as a gold standard, a sensitivity of 68.1% and a specificity of 96.4% were recorded for LAMP and a sensitivity of 75.9% and a specificity of 83.8% for ELISA. The Kappa coefficient between nRLB and LAMP indicated a significant level of agreement (0.692), but only moderate concordance (0.572) between nRLB and ELISA. The results of the present study confirm and extend earlier findings regarding the widespread of T. lestoquardi infections in sheep in the Sudan. The data provide evidence that should enable the veterinary authorities to deploy appropriate control measures.

Kivata MW, Mbuchi M, Eyase FL, Bulimo WD, Kyanya CK, Oundo V, Muriithi SW, Andagalu B, Mbinda WM, Soge OO, McClelland SR, Sang W, Mancuso JD. "gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya." BMC Microbiol.. 2019;19(1):76. Abstractkivata_et_al-2019-bmc_microbiology.pdf

Phenotypic fluoroquinolone resistance was first reported in Western Kenya in 2009 and later in Coastal Kenya and Nairobi. Until recently gonococcal fluoroquinolone resistance mechanisms in Kenya had not been elucidated. The aim of this paper is to analyze mutations in both gyrA and parC responsible for elevated fluoroquinolone Minimum Inhibitory Concentrations (MICs) in Neisseria gonorrhoeae (GC) isolated from heterosexual individuals from different locations in Kenya between 2013 and 2017.

Nthiwa D, Alonso S, Odongo D, Kenya E, Bett B. "Zoonotic Pathogen Seroprevalence in Cattle in a Wildlife-Livestock Interface, Kenya." Ecohealth. 2019;16(4):712-725. Abstract

A cross-sectional study was conducted to determine the seroprevalence of Brucella spp. and Leptospira spp. and risk factors of exposure in cattle in three zones with varying land use types and wildlife-livestock interactions. Five villages were selected purposively; two in areas with intensive livestock-wildlife interactions (zone 1), another two in areas with moderate livestock-wildlife interactions (zone 2) and one in areas where wildlife-livestock interactions are rarer (zone 3). Sera samples were collected from 1170 cattle belonging to 390 herds in all the zones and tested for antibodies against Brucella abortus and Leptospira interrogans serovar hardjo using ELISA kits. Data on putative risk factors for seropositivity of these pathogens in cattle were collected using a questionnaire. The overall apparent animal-level seroprevalence of brucellosis and leptospirosis was, respectively, 36.9% (95% CI 34.1-39.8) and 23.5% (95% CI 21.1-26.0). Brucella spp. seroprevalence was higher in zone 1 than in zones 2 and 3 (χ = 25.1, df = 2, P < 0.001). Zones 1 and 2 had significantly higher Leptospira spp. seroprevalence than zone 3 (χ = 7.0, df = 2, P = 0.029). Results of multivariable analyses identified animal sex (female) and zones (high interface area) as significant predictors (P < 0.05) of animal-level seropositivity of Brucella spp. For Leptospira spp., important predictors of animal-level seropositivity were animal sex (female), zones (moderate interface area) and herds utilizing a communal grazing reserve. The seroprevalences of Brucella spp. and Leptospira spp. in cattle were higher in areas with moderate to high wildlife-livestock interactions than those with rare interactions.

Attardo GM, Abd-Alla AMM, Acosta-Serrano A, Allen JE, Bateta R, Benoit JB, Bourtzis K, Caers J, Caljon G, Christensen MB, Farrow DW, Friedrich M, Hua-Van A, Jennings EC, Larkin DM, Lawson D, Lehane MJ, Lenis VP, Lowy-Gallego E, Macharia RW, Malacrida AR, Marco HG, Masiga D, Maslen GL, Matetovici I, Meisel RP, Meki I, Michalkova V, Miller WJ, Minx P, Mireji PO, Ometto L, Parker AG, Rio R, Rose C, Rosendale AJ, Rota-Stabelli O, Savini G, Schoofs L, Scolari F, Swain MT, Takáč P, Tomlinson C, Tsiamis G, Van Den Abbeele J, Vigneron A, Wang J, Warren WC, Waterhouse RM, Weirauch MT, Weiss BL, Wilson RK, Zhao X, Aksoy S. "Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes." Genome Biol. 2019;20(1):187. Abstract

Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.

Katz MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, Crane J, Doroshenko A, Ebruke BE, Edwards KM, Fortuna L, Jagelaviciene A, Joshi J, Kemp J, Kovacs S, Lambach P, Lewis KDC, Ortiz JR, Simões EAF, Turner P, Tagbo BN, Vaishnavi V, Bonhoeffer J. "Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data." Vaccine. 2019;37(2):392-399.
Chepkonga S. "Administrative Strategies for Using Social Media in Higher Education Institutions in Kenya.". In: International Conference on Research and Innovation in Education University of Nairobi.; 2019.
Kamau F, Strijdom H, Mwangi P, Blackhurst D, Imperial E, Salie R. "Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.". 2019;121:106577. AbstractWebsite

Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alpha/gamma (PPARα/γ) stimulation mitigates HAART-induced metabolic dysfunction, vascular effects are unresolved. To investigate whether HAART induces vascular dysfunction in obesity and to explore the underlying mechanisms of PPARα/γ stimulation, male Wistar rats were placed on a high-calorie diet for 16 weeks. After 10 weeks, HAART (lopinavir/ritonavir, azidothymidine/lamivudine) with/without PPARα/γ agonist, Saroglitazar, was administered daily for six weeks. Excised thoracic aorta rings were subjected to isometric tension studies and Western blot measurements. HAART+Saroglitazar-treated obese animals recorded lower adiposity indices (4.3 ± 0.5%) vs. HAART only-treated obese rats (5.6 ± 0.3%; p < .01). Maximum acetylcholine-induced vasorelaxation (Rmax), was lower in obese+HAART group (76.10 ± 3.58%) vs. obese control (101.40 ± 4.75%; p < .01). However, Rmax was improved in obese+ HAART+Saroglitazar (101.00 ± 3.12%) vs. obese+HAART rats (p < .001). The mean LogEC50 was improved in obese+HAART+Saroglitazar vs. obese+HAART group; p = .003. Improved endothelial function in obese+ HAART+Saroglitazar group was associated with upregulation of eNOS, PKB/Akt and downregulated p22-phox expression vs. obese+HAART group. Therefore, PPARα/γ stimulation attenuated HAART-induced endothelial dysfunction by upregulating vasoprotective eNOS, PKB/Akt signaling and downregulating pro-oxidative p22-phox expression.

Wangai FK, Masika MM, Lule GN, Karari EM, Maritim MC, Jaoko WG, Museve B, Kuria A. "Bridging antimicrobial resistance knowledge gaps: The East African perspective on a global problem." PLoS ONE. 2019;14(2):e0212131. Abstract

There is worldwide concern of rapidly increasing antimicrobial resistance (AMR). However, there is paucity of resistance surveillance data and updated antibiograms in Africa in general. This study was undertaken in Kenyatta National Hospital (KNH) -the largest public tertiary referral centre in East & Central Africa-to help bridge existing AMR knowledge and practice gaps.

Ntwiga DB. "Can FinTech Shape the Dynamics ofConsumer Credit Usage among theUn(der)banked?". In: Kenya Bankers Association Working Paper Series.; 2019. Abstract

We use the 2016 FinAccess Household survey data of 2015 from 8665 households and desktop reviews to examine how perceptions, behaviour, financial literacy and socio-economic characteristics of un(der) banked consumers can shape their dynamics towards credit usage. The challenges and opportunities for the market players are examined using desktop reviews and their role towards an increase in financial inclusion and credit usage through FinTech. The disruptive innovations have provided new possibilities, challenges and opportunities to boost financial and credit usage in the market. Consumer perceptions on cost, trust, source of financial advice, financial literacy and socio-economic characteristics influences credit usage. The business models being developed by the FinTech providers are taunted to change the landscape of lending to the un(der) banked

Kalai, J.M., Mulu C. "Determinants of Female Teachers' Progression to Governance Positions in Public Primary Schools in Mutitu Sub County , Kenya.". In: International Conference on Research and Innovation in Education University of Nairobi.; 2019.
Chege BM, Waweru MP, Frederick B, Nyaga NM. "The freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb possess hypoglycemic, hypolipidemic and hypoinsulinemic on type 2 diabetes rat model.". 2019;244:112077. AbstractWebsite

Ethnopharmacological relevanceRotheca myricoides (Hochst.) Steane & Mabb is a plant species used in traditional medicine for the management of diabetes in the lower eastern part of Kenya (Kitui, Machakos and Makueni Counties, Kenya) that is mainly inhabited by the Kamba community.
Aim
This study investigated the antihyperglycaemic, antidyslipidemic and antihyperinsulinemic activity of the freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb (RME) in an animal model of type 2 diabetes mellitus.
Methods
Type 2 diabetes was induced by dietary manipulation for 56 days via (high fat- high fructose diet) and intraperitoneal administration of streptozocin (30 mg/kg). Forty freshly-weaned Sprague Dawley rats were randomly assigned into the negative control (high fat/high fructose diet), low dose test (50mg/kg RME, high dose test (100mg/kg RME and positive control (Pioglitazone, 20mg/kg) groups. Fasting blood glucose and body weight were measured at weekly intervals. Oral glucose tolerance tests were performed on days 28 and 56. Lipid profile, hepatic triglycerides, fasting serum insulin levels and serum uric acid were determined on day 56.
Results
The RME possessed significant antihyperglycemic [FBG: 6.5 ± 0.11 mmol/l (negative control) vs. 4.62 ± 0.13 mmol/l (low dose test) vs. 5.25 ± 0.15 mmol/l in (high dose test) vs. 4.33 ± 0.09 mmol/l (positive control): p < 0.0001] and antihyperinsulinemic effects [1.84 ± 0.19 (negative control) vs. (0.69 ± 0.13 (low dose test) vs. (0.83 ± 0.17 (high dose test) vs. (0.69 ± 0.10 (positive control): F (3, 36) = 0.6421: p < 0.0001. The extracts also possessed significant antidyslipidemic effects [LDL levels: 3.52 ± 0.19 mmol/l (negative control) vs. 0.33 ± 0.14 mmol/l (low dose test) vs. 0.34 ± 0.20 mmol/l (high dose test) vs. 0.33 ± 0.01 mmol/l (positive control): p < 0.0001].RME significantly lowered plasma uric acid levels, as well as hepatic triglycerides and hepatic weights. Network pharmacology analysis indicated that the observed pharmacological effects are mediated via the modulation of Peroxisome proliferator-activated gamma receptor.
Conclusions
The freeze dried extracts of Rotheca myricoides possessed significant antihyperglycemic and antidyslidemic effects. In addition it lowered serum uric levels, as well as hepatic triglycerides and hepatic weight. These results appear to validate the traditional use of this plant species in the management of diabetes mellitus.

Arunga S, Wiafe G, Habtamu E, Onyango J, Gichuhi S, Leck A, Macleod D, Hu V, Burton M. "The impact of microbial keratitis on quality of life in Uganda." BMJ Open Ophthalmol. 2019;4(1):e000351. AbstractWebsite

Background: Microbial keratitis (MK) is a frequent cause of sight loss in sub-Saharan Africa. However, no studies have formally measured its impact on quality of life (QoL) in this context.
Methods: As part of a nested case-control design for risk factors of MK, we recruited patients presenting with MK at two eye units in Southern Uganda between December 2016 and March 2018 and unaffected individuals, individually matched for sex, age and location. QoL was measured using WHO Health-Related and Vision-Related QoL tools (at presentation and 3 months after start of treatment in cases). Mean QoL scores for both groups were compared. Factors associated with QoL among the cases were analysed in a linear regression model.
Results: 215 case-controls pairs were enrolled. The presentation QoL scores for the cases ranged from 20 to 65 points. The lowest QoL was visual symptom domain; mean 20.7 (95% CI 18.8 to 22.7) and the highest was psychosocial domain; mean 65.6 (95% CI 62.5 to 68.8). At 3 months, QoL scores for the patients ranged from 80 to 90 points while scores for the controls ranged from 90 to 100. The mean QoL scores of the cases were lower than controls across all domains. Determinants of QoL among the cases at 3 months included visual acuity at 3 months and history of eye loss.
Conclusion: MK severely reduces QoL in the acute phase. With treatment and healing, QoL subsequently improves. Despite this improvement, QoL of someone affected by MK (even with normal vision) remains lower than unaffected controls.

Hammadi R, Kúsz N, Mwangi PW, Kulmány Á, Zupkó I, Orvos P, Tálosi L, Hohmann J, Vasas A. "Isolation and Pharmacological Investigation of Compounds From Euphorbia matabelensis." Natural Product CommunicationsNatural Product Communications. 2019;14(7):1934578X19863509. AbstractWebsite

This work deals with the isolation and pharmacological investigations of compounds of Euphorbia matabelensis. After multiple separation process, including thin layer chromatography (TLC), vacuum liquid chromatography, preparative TLC, and high-performance liquid chromatography, 1 diterpene (ingenol) and 2 flavonoids (naringenin and eriodictyol) were obtained from the methanol extracts prepared from the stems and roots of the plant. The structures of the isolated compounds were determined by nuclear magnetic resonance (NMR) and MS measurements and comparison with literature data. All compounds were isolated for the first time from the plant. Eriodictyol was detected for the first time from a Euphorbia species. The compounds were tested for their antiproliferative (on HeLa, C33a, MCF-7, and MDA-MB-231 cell lines) and GIRK channel blocking activities. None of the compounds proved to be active in these test systems.

Bore M. "Management of complications of cosmetic iris implants in phakic eyes: a case report and literature review.". In: Ophthalmological Society of Kenya Congress. Naivasha, Kenya; 2019.
Bore M. "Management of dry eye disease in clinical practice.". In: Ophthalmological Society of Kenya Congress. Naivasha, Kenya; 2019.
Bore M. "Ocular misery tidbits.". In: Ophthalmological Society of Kenya Congress. Naivasha, Kenya; 2019.
Ngaruiya N, Orwa D, Waiganjo P. "Situation Analysis and Technology Value Proposition for Geriatric Care for Philanthropic Social Homes in Kenya.". In: IST-Africa Week Conference. Nairobi, Kenya; 2019. Abstract

The growth of the graying population all over the world is showing a great need of incorporating ICT to ensure healthy living. Geriatric persons in philanthropic social homes (PSH) in developing countries are not favored in terms of infrastructure, housing, caregiving as well as privacy since they are in a controlled communal environment. These philanthropic homes, commonly known as `Nyumba za Wazee' in Kenya are slowly gaining reputation as more of the elderly are ostracized because of inheritance or even abandonment. The aim of this paper is to bring fourth the status quo of the geriatric persons living in PSH, the challenges they face, which have tremendous ramifications that leads to strong incentives to usage of low cost technology to alleviate the lives of the elderly towards healthy living in their higher ages. The researchers, through the social department and Board of management of these social homes, carried a research for a period of 3 months in two PSHs, in Nairobi County and Kiambu County. Interviews and storytelling were the two data collection techniques used. The findings from these two PSHs, categorized the challenges as; physical, and psychological challenges. This research argues that low affordable technology solutions will curb these challenges to ensure adequate care and provide decent standards of living for the elderly in PSH.

Dean W, Gichuhi S, Buchan J, Matende I, Graham R, Kim M, Arunga S, Makupa W, Cook C, Visser L, Burton M. "Survey of ophthalmologists-in-training in Eastern, Central and Southern Africa: A regional focus on ophthalmic surgical education." Wellcome Open Res. 2019;4:187. AbstractWebsite

There are 2.7 ophthalmologists per million population in sub-Saharan Africa, and a need to train more. We sought to analyse current surgical training practice and experience of ophthalmologists to inform planning of training in Eastern, Central and Southern Africa. This was a cross-sectional survey. Potential participants included all current trainee and recent graduate ophthalmologists in the Eastern, Central and Southern African region. A link to a web-based questionnaire was sent to all heads of eye departments and training programme directors of ophthalmology training institutions in Eastern, Central and Southern Africa, who forwarded to all their trainees and recent graduates. Main outcome measures were quantitative and qualitative survey responses. Responses were obtained from 124 (52%) trainees in the region. Overall level of satisfaction with ophthalmology training programmes was rated as 'somewhat satisfied' or 'very satisfied' by 72%. Most frequent intended career choice was general ophthalmology, with >75% planning to work in their home country post-graduation. A quarter stated a desire to mainly work in private practice. Only 28% of junior (first and second year) trainees felt surgically confident in manual small incision cataract surgery (SICS); this increased to 84% among senior trainees and recent graduates. The median number of cataract surgeries performed by junior trainees was zero. 57% of senior trainees were confident in performing an anterior vitrectomy. Only 29% of senior trainees and 64% of recent graduates were confident in trabeculectomy. The mean number of cataract procedures performed by senior trainees was 84 SICS (median 58) and 101 phacoemulsification (median 0). Satisfaction with post-graduate ophthalmology training in the region was fair. Most junior trainees experience limited cataract surgical training in the first two years. Focused efforts on certain aspects of surgical education should be made to ensure adequate opportunities are offered earlier on in ophthalmology training.

Ang'u C, Muthama NJ, Kong'ani LNS. "Towards Replacing Kerosene with Bioethanol in Developing Countries: A Review.". In: Conference on the Status of African Women. University of Nairobi; 2019.
Chege BM, Birech Z, Mwangi PW, Bukachi FO. "Utility of Raman spectroscopy in diabetes detection based on biomarker Raman bands and in antidiabetic efficacy studies of herbal extract Rotheca myricoides Hochst." Journal of Raman SpectroscopyJournal of Raman Spectroscopy. 2019;50(10):1358-1366. AbstractWebsite

Abstract Diabetes is a disease characterized by hyperglycaemia because of insufficient or nonproduction of insulin from the pancreas. Establishing prediabetic and diabetic condition often involves monitoring levels of glucose and some amino acids in blood using nonrapid and label-dependent methods. This work reports on a method with a potential of being used for quick label-free detection of diabetes mellitus type II based on Raman spectroscopy of blood applied onto a conductive silver-smeared glass slide. We show that Raman spectral profile from blood of streptozotocin-induced diabetic Sprague Dawley rats emanates from overlap of signals from valine, leucine, isoleucine, creatine, glucose, and fructose. The Raman spectral bands associated with these biomolecules have the potential of being used in prediabetic detection and diabetes prediction. Characteristic intense peaks in diabetic rat's blood spectra were centred at wave numbers 537 cm?1 associated with valine's CO2? rocking vibration, 829 cm?1 assigned to CH2 rocking vibration in leucine and 917?960 cm?1 ascribed to C?C and C?N stretching and CH3 rocking vibrations in various biomolecules. The average intensities of these bands were sensitive to antidiabetic drug administration on the rats as their values approached those of nondiabetic rats and so could be used as diabetes biomarker bands. Statistical analyses together with evaluation of average intensities of these biomarker bands showed that the herbal extract Rotheca myricoides Hochst had greater antidiabetic effect at low dose (50 mg/kg of body weight) than at high dose (100 mg/kg of body weight). A similar result was seen with area under curve values and could act as an additional parameter in diabetes detection and prediction.

Wasamba P, undefined. "The agony that retiring Professors go through." The Standard, July 2, 2019:15.
"Training Course on Household Surveys.". In: Training Course on Household Surveys.; 2019. Abstract

“to answer questions that have been raised, to solve problems that have been posed or observed, to assess needs and set goals, to determine whether or not specific objectives have been met, to establish baselines against which future comparisons can be made, to analyze trends across time, and generally, to describe what exists, in what amount, and in what context.” (Isaac & Michael, 1997, p. 136)

K O. "Institutional Independence & Accountability: Some Ideas for Enhancing Accountability of the Judiciary to Address Corruption.". In: Kabarak Law School International Conference on Corruption. Kabarak Law School, Nakuru, Kenya; 2019.
Rop K, Karuku GN, Mbui D, Njomo N, Michira I. "Evaluating the effects of formulated nano-composite NPK fertilizer on growth and yield of maize, kale and capsicum29th Soil Science Society of Eastern Africa (SSSEA) held in Lake Naivasha Country Club in Naivasha town,Nakuru County from 18th-22nd Nov2019.". In: 29th Soil Science Society of Eastern Africa (SSSEA) . Lake Naivasha Country Club in Naivasha town, Nakuru County ; 2019.
Ipara BO, Otieno DJ, Nyikal RA, Makokha SN. "The role of chicken production systems and management practices on Newcastle Disease outbreaks in Kenya .". In: Tropentag Conference at Universities of Kassel & Goettingen. Germany; 2019.
Mumma-Martinon CA. "I Implications of Debt-Trap Diplomacy: The Case of Kenya Standard Gauge Railway from Mombasa to Nairobi.". In: From Sino Africa to Afro-China Engagement in the 21st Century: Emerging Interdisciplinary Issues and Research Gaps . University of Nairobi ; 2019.
Olali T. "Ritual and Spectacle: The Grandiloquent Display of Paradoxical Metamessage during the Lamu Maulidi Festival.". In: Institutions of African Literature: Future, Present, Past. Columbus, Ohio, USA ; 2019.
undefined. "Streamline and standardize part-time lecturers’ terms." Daily Nation, August 17, 2019:32.
undefined. "Are universities losing autonomy or just resisting accountability?" Daily Nation, March 15, 2019:14.
"Swala la Mipaka ya Kiutanzu:Uchunguzi wa Riwaya,Hadithi fupi,Novela na Insha.". In: CHAWAKAMA. Kyambogo University,Uganda; 2019.
omari HK. "Islam in Africa.". In: philosophy,religion in Africa. university of Nairobi; 2019.
Simiyu MT, Nyongesa FW, Aduda BO, Birech Z, Mwebaze G. "2. Mary T. Simiyu, Francis W. NyongesaApplication of An Organic Plant-Derived Binder in the Fabrication of Diatomaceous Earth Waste-Based Membranes for Water Purification Systems.". In: 10th International Conference of the African Materials Research Society (AMRS2019). Arusha, Tanzania,; 2019.
Owino B, Ogacho A, Nyongesa FW, Aduda BO, Odari V. "Effect of TiO2 Compact Layer on Photovoltaic Characteristics of TiO2/Nb2O5 Dye Sensitized Solar Cells.". In: 10th International Conference of the African Materials Research Society (AMRS2019). Arusha, Tanzania, ; 2019.
Sorensen, Olago, D. O., Dulo, Kanoti, Gaye, Faye, Pouye, Owor. "Real-time indication of faecally contaminated drinking water with fluorescence spectroscopy: towards understanding the causation.". In: 10th International Groundwater Quality Conference (GQ 2019). Liège, Belgium; 2019.
Overview of Retinopathy of prematurity. Nairobi: College of Ophthalmology of Eastern, Central & Southern Africa; 2019.overview_of_retinopathy_of_prematurity._njambi.pdf
EW M, JD M. Common skin tumors in dogs and cats: A review. CSD, University of Nairobi. Nairobi; 2019.
Mbuge DO, Negrini R, Nyakundi LO, Kuate SP, Ranajit Bandyopadhyay, Muiru WM, Baldwyn Torto RM. "Application of superabsorbent polymers (SAP) as desiccants to dry maize and reduce aflatoxin contamination.". In: 2nd International Conference of the Pan African Society of Agricultural Engineers (PASAE), . Rabat, Morocco; 2019.
and Mwangi, I. K., Mugo FW, Ndegwa E. "Land Fragmentation and Its Potential Effects on Maize Production in Kenya. Paper Presented at Maize for Kenya Consultative Workshop.". In: Maize for Kenya Consultative Workshop. ICRAF, Nairobi; 2019.
Mbembe EA, Otieno DJ, Nyikal R, Odendo M. "Determinants of market participation by smallholder soybean farmers in Kakamega County, Kenya”.". In: 6th African Association of Agricultural Economists (AAAE) . Abuja, Nigeria; 2019.
Ojwang SO, Otieno DJ, Okello JJ, Muoki P, Nyikal RA. "Does nutrition education influence retention of vitamin A biofortified orange-fleshed sweet potato in farms? Evidence from Kenya.". In: 6th African Association of Agricultural Economists (AAAE) . Abuja, Nigeria; 2019.
Ipara BO, Otieno DJ, Nyikal RA, Makokha SN. "The role of unregulated chicken marketing practices on the frequency of Newcastle Disease outbreaks in Kenya." African Journal of Agricultural Research . 2019;12(24):2093-2100. AbstractWebsite

In developing countries, chicken trade is characterized by complex chains comprising of many actors with limited biosecurity. This increases the spread of chicken diseases like Newcastle disease (ND). In Kenya, there is lack of uniformity in practices used in live bird markets, leading to increased disease outbreaks. This study aimed at assessing the effects of the chicken marketing practices on the frequency of ND outbreaks. A Poisson regression (PRM) was used on data collected from 336 traders selected using multi-stage sampling in Kakamega, Machakos, and Nairobi. Results highlight the low access of trainings and credit by traders. From the PRM results, breed composition, market channel, transportation, origin of birds, mixing of birds, slaughter of birds, disposal of waste, and housing as well as trader attributes like ND awareness, licensing, gender, and age had significant effects on the frequency of ND outbreaks. The study recommends that County governments collaborate with development partners to develop innovative ways of disseminating information on ND. The County governments should invest in market infrastructure such as slaughter facilities, special shelters and waste disposal equipment. There is also need for enforcement of biosecurity and hygiene measures through regular market inspections.

Keywords: biosecurity; live bird market; marketing channel; unregulated practice.

Mutuku MW, Brianna R Beechler, Ibrahim N Mwangi, Otiato FO, Horace Ochanda B. " A Search for Snail-Related Answers to Explain Differences in Response of Schistosoma mansoni to Praziquantel Treatment among Responding and Persistent Hotspot Villages along the Kenyan Shore of Lake Victoria." The American journal of tropical medicine and hygiene. 2019:tpmd190089.
Ongolly FK, Bukachi SA. " Barriers to men’s involvement in antenatal and postnatal care in Butula, western Kenya. ." African Journal of Primary Health Care & Family Medicine . 2019;11(1):a1911.
Uwizeyimana D, Mureithi SM, Mureithi SM, Mvuyekure SM, Karuku G, Karuku G. " Modelling surface runoff using the soil conservation service-curve number method in a drought prone agro-ecological zone in Rwanda. International Soil and Water Conservat." International Soil and Water Conservation Research. 2019;7 (1):9-17.
Uwizeyimana D, Mureithi, S.M., Mvuyekure SM, Karuku G, Kironchi G. " Modelling surface runoff using the soil conservation service-curve number method in a drought prone agro-ecological zone in Rwanda. International Soil and Water Conservat." International Soil and Water Conservation Research. 2019;7 (1):9-17.
Mwonga NK, Gitau AN, Mutua JM, Mwangi ST. " Optimization of Specific Draft Requirement and Hitch Length for an Animal Drawn Sub-Soiler: A Case of SandyClay Loam Soils." Open Journal of Optimization. 2019;Volume 8:83-99.
Opiyo R, Muketha S, Omollo W, Mwaniki D. " Responsive Infrastructure and Service Provision Initiatives Framing Smart Environment Attainment in Nairobi.". In: Smart Environment for Smart Cities. Singapore: Springer; 2019.
Jacquiline Kisianan Kenana, James Mucunu Mbaria CKKPOO. " Toxicological and Phytochemical Evaluation of Uvariodendron kirkii. (2019)." The Journal of Ethnobiology and Traditional Medicine.. 2019.
Inyo DN. "). Service Quality and Operational Performance of Tour Operators in Kenya." African Journal of Business and Management (AJBUMA). 2019;Vol.5(No.1):43-61.
Njau DG, Muge EK, Kinyanjui PW, Omwandho C, Mukwana S. "1. STRs analysis of human DNA from Maggots Fed on Decomposing Bodies: Assessment of the time period for successful analysis ." Egyptian Journal of Forensic Science . 2019;6(3):261-269. AbstractFull Text Link

Frequently, forensic entomology is applied in the use of insect maggots for the identification of specimens or remains of humans. Maggot crop analysis could be valuable in criminal investigations when maggots are found at a crime scene and a corpse is absent. Human short tandem repeat (STR) has previously been used to support the association of maggots to a specific corpse but not in the period at which the body has been decomposing. The aim of this research was to assess the time period for successful STR analyses of human DNA from third instar maggots (Protophormia terraenovae) obtained from decomposing human corpses as well as to investigate the human DNA turnover and degradation in the maggot crop after they are removed from food and/or are fed on a beef (a new/different) food source. Results showed that the amount of human DNA recovered from maggots decreased with time in all cases. For maggots fed on beef, the human DNA could only be recovered up to day two and up to day four for the starved maggots. STR analyses of human DNA from maggots’ crop content using 16 loci generated profiles that matched those of reference samples although some of the alleles were not amplifiable therefore generating partial profiles for the samples starved for 4 days and those fed on beef. This may be due to nuclease activity present in the gut of larvae that may have caused degradation of DNA and consequently reduction in DNA yield. It was possible to identify the decomposing body using STRs as markers.

Njau DG, Muge EK, Kinyanjui PW, Omwandho C, Mukwana S. "1. STRs analysis of human DNA from Maggots Fed on Decomposing Bodies: Assessment of the time period for successful analysis ." Egyptian Journal of Forensic Science . 2019;6(3):261-269. AbstractFull Text Link

Frequently, forensic entomology is applied in the use of insect maggots for the identification of specimens or remains of humans. Maggot crop analysis could be valuable in criminal investigations when maggots are found at a crime scene and a corpse is absent. Human short tandem repeat (STR) has previously been used to support the association of maggots to a specific corpse but not in the period at which the body has been decomposing. The aim of this research was to assess the time period for successful STR analyses of human DNA from third instar maggots (Protophormia terraenovae) obtained from decomposing human corpses as well as to investigate the human DNA turnover and degradation in the maggot crop after they are removed from food and/or are fed on a beef (a new/different) food source. Results showed that the amount of human DNA recovered from maggots decreased with time in all cases. For maggots fed on beef, the human DNA could only be recovered up to day two and up to day four for the starved maggots. STR analyses of human DNA from maggots’ crop content using 16 loci generated profiles that matched those of reference samples although some of the alleles were not amplifiable therefore generating partial profiles for the samples starved for 4 days and those fed on beef. This may be due to nuclease activity present in the gut of larvae that may have caused degradation of DNA and consequently reduction in DNA yield. It was possible to identify the decomposing body using STRs as markers.

Oredo J. "3D Printing: From Manufacturing to Infofacturing." MANAGEMENT November (2019).
Zalasiewicz J, Waters CN, Williams M, Summerhayes CP, Odada E, Wagreich M, Draganits E, Edgewor M. "7 The Stratigraphic Boundary of the Anthropocene.". In: The Anthropocene as a Geological Time Unit: A Guide to the Scientific Evidence and Current Debate. Cambridge University Press; 2019. Abstract

Here we outline the basis on which a formal proposal should be made for potential inclusion of the Anthropocene in the Geological Time Scale, examining the scale and rate of human change to the Earth System to help recognise the point at which anthropogenic impacts became of sufficient scale to allow discrimination of the Anthropocene as a geological unit. This examination covers such factors as impacts from early hominin species, the first human artefacts, early ecosystem modification through agriculture, deforestation, the domestication of animals, urbanisation, metal mining and smelting and early globalisation. The Industrial Revolution, starting in the UK in the 18th century, and the global Great Acceleration of the mid-20th century, are investigated, as both provide popular narratives that explain the Earth System changes indicative of the Anthropocene, with the latter producing the near-synchronous stratigraphic signals most consistent with an effective geological time boundary. We assess which hierarchical level–age, epoch, period, era or eon–seems most suitable for the Anthropocene, and suggest that epoch (= series) level is conservative and appropriate. The Anthropocene might be defined via a Global Standard Stratigraphic Age or a Global boundary Stratotype Section and Point, with the latter being most appropriate. Finally, we assess the kinds of geological environments, including anoxic marine basins, annually banded coral and bivalve skeletons, estuaries and deltas, lake floors, peat mires, anthropogenic deposits, polar ice, speleothems and tree rings, in which such a physical reference level might be placed.

Ebrahim YH, Mvusi S. "About: Lessons in software design architecture and development.". In: Selby Mvusi and beyond. Nairobi, Kenya: Ebenergy Enterprises; 2019.
Ebrahim YH, Mvusi S. "About: Lessons in software design architecture and development.". In: Selby Mvusi and beyond. Nairobi, Kenya: Ebenergy Enterprises; 2019.
Ebrahim YH, Mvusi S. "About: Lessons in software design architecture and development.". In: Selby Mvusi and beyond. Nairobi, Kenya: Ebenergy Enterprises; 2019.
Kehinde M, Barasa L. "Absorptive capacity, marketing capabilities and innovation commercialization in Nigeria." European Journal of Innovation Management. 2019;22(5):790-821.
HM M. "Academic Processes of postgraduate studies; from admission to graduation." Kenya Climate Smart Agriculture postgraduate induction workshop, Nakuru; 2019.
Ismail LW, ZP Q, SB O. "The acceptability of HIV testing among women receiving post abortion care." South Sudan Medical Journal. 2019;12(3):101-105. AbstractWebsite

Introduction: In South Sudan few women have heard about the HIV. The prevalence of HIV infection in the country is 2.6%. Post abortion care (PAC) accounts for over 50% of all gynaecological admissions at the Juba Teaching Hospital (JTH). HIV testing is not routinely offered as part of PAC services.

Objective: To determine factors associated with acceptability of HIV testing among women receiving PAC at JTH.

Methods: This was a cross-sectional study, conducted at the Gynaecological Unit of JTH. Three hundred and forty patients were interviewed using a structured questionnaire.

Results: The mean age of the participants was 24.7 years with 50.5% aged <25years, 31.5% were employed, and 31.8% had no formal education. Acceptability of HIV testing was 70.9% and the prevalence of HIV was 2.7%. The most common reason for not accepting, was the belief, based on previous results, that they were HIV negative. Patients aged ≥25 years and those with primary and secondary education were twice as likely to accept HIV testing than those <25 years and those with no formal education, respectively. Employment status, religion and marital status were not statistically associated with acceptability of HIV testing. Patients previously tested for HIV were more likely to accept testing.

Conclusion: Routine HIV testing should be integrated into PAC services with efforts to increase awareness of HIV and importance of testing

Key words: HIV, abortion, post-abortion care, South Sudan

"Access to Justice for Intra Familial Child Sexual Abuse Victims in Kenya: A Mirage?”." International Journal of Social Science and Economic Research . 2019;4(7):4997.
Mbwika JM, wa Mberia K, Oduor JAN. "Adaptation Strategies in Rabai Loanwords." Asian Journal of African Studies (AJAS). 2019;46(ISSN 2466- 1821.).
Awori M, Mehta N, Kebba N, Makori. E. "Adding Blood to St Thomas Solution Does Not Improve Mortality in Pediatric Cardiac Surgery; A Meta-analysis of a Homogenous Population." Annals of African Surgery. 2019. AbstractWebsite

Background: Cardioplegia is the gold standard for providing ideal operating conditions while effecting myocardial protection. Some studies suggest that adding blood to St Thomas cardioplegia solution improves efficacy; this is generally accepted as true. However, the few meta-analyses conducted on children have pooled heterogeneous populations; this raises concern about the validity of their conclusions. Methods: PUBMED, the Cochrane Library and Google Scholar were searched systematically until March 2019 using the search terms “cardioplegia”; “myocardial protection”; “pediatric” “pediatric”; “children”; “infants”; “neonates”. Full text articles were examined if abstracts revealed that the studies possibly contained a blood cardioplegia arm and a crystalloid cardioplegia arm. Studies were included in the meta-analysis if they had a 4:1 blood cardioplegia arm and a St Thomas solution arm. Meta-analysis was performed using Meta-Mar software. Results: The search retrieved 423 articles; 5 were included in the meta-analysis, representing 324 patients. The risk ratio for operative mortality was 0.77(95% CI 0.24–2.5; p=0.66). Little evidence was seen of heterogeneity of the pooled patients. Conclusion: Adding blood to St Thomas cardioplegia solution did not improve in-hospital operative mortality; this may have implications for blood cardioplegia use.

Gathumbi JK, Kimani, J.M., Mutisya P, Kombe, Yeri, Wamunyokoli, Fred W, Mbakaya, Charles FL. "The Additive Effect of Hepatitis B Virus and Aflatoxin B1 to Liver Disease Burden: A Case Study in Kitui, Makueni and Machakos Counties, Kenya." Journal of Health and Medical Sciences. 2019;2(3):312-331.
Kong'ani LNS, Ang'u C, Muthama NJ. "Adoption of improved cookstoves in the peri-urban areas of Nairobi: Case of Magina area, Kiambu County, Kenya." Journal of Sustainability, Environment and Peace. 2019; 1(1):19-24.
Kong’ani LNS, Ang’u C, Muthama NJ. "Adoption of improved cookstoves in the peri-urban areas of Nairobi: Case of Magina area, Kiambu county, Kenya. ." Journal of Sustainability, Environment and Peace. 2019;1(1):19-20.
Mwaniki JM, Onyatta JO, Yusuf AO. "Adsorption of Heavy Metal Ions from Aqueous Solutions and Wastewater using Water Hyacinth Powder ." International Journal of Trend in Scientific Research and Development (IJTSRD) . 2019;4(1):1-5.
Mwaniki JM, Onyatta JO, Yusuf AO. "Adsorption of Heavy Metal Ions from Aqueous Solutions and Wastewater using Water Hyacinth Powder." Adsorption. 2019;4(1). AbstractAdsorption Journal

ABSTRACT
The adsorption of heavy metals on water hyacinth powder from both
wastewater and aqueous solution was studied using batch experiments. The
adsorption efficiency of water hyacinth powder was evaluated in this study.
The levels of heavy metals in wastewater were in the range of: 1.2-75.3 ppm
for lead, 0.4-87.6 ppm for chromium, 0.1-63.5 ppm for nickel, 0.5-95.5 ppm for
zinc and 0.8-52.7 ppm for cadmium. The levels of zinc, lead and cadmium were
above the limits set by the write NEMA in full then bracket (NEMA) for
discharge into the environment (0.01 ppm for cadmium and lead, 0.5 ppm for
zinc). The adsorption efficiency of hyacinth powder was higher in aqueous
solution than in wastewater while at low metal concentrations (0.1-3.2 ppm),
the adsorption efficiency of water hyacinth powder was 100% in both
wastewater and aqueous solution. The study showed that water hyacinth
powder is a low cost adsorbent which could be used to remove heavy metals
from wastewater and aqueous solution.

Opanga L, Mulaku MN, Opanga SA, Godman B, Kurdi A. "Adverse effects of chemotherapy and their management in Pediatric patients with Non-Hodgkin's Lymphoma in Kenya: A descriptive, situation analysis study." Expert Review of anticancer therapy. 2019;19(5):423-430.
Makunda CS. "African Development and Management: 6A - Development in Nairobi: Three Into One Does Not Go!". In: Intrinsic Capability: Implementing Intrinsic Sustainable Development for an Ecological Civilisation. London: World Scientific; 2019.
Park J, Michira JN, Yun SY. "African hip hop as a rhizomic art form articulating urban youth identity and resistance with reference to Kenyan genge and Ghanaian hiplife." Journal of the Musical Arts in Africa. 2019;Vol. 16(No. 1-2):99-118.
Amugune BK, Otieno-Omutoko L. "An African Perspective of Benefits in Social Science Research.". In: Social Science Research Ethics in Africa.Research Ethics Forum, vol 7. Nortjé N., Visagie R., Wessels J. (eds). Cham : Springer; 2019.
OLUOCH M F. "Age And Effective Human Resource Management." European Scientific Journal. 2019;15(34):ISSN: 1857-7881 (Print) e - ISSN 1857-7431.
Gitari HI, Shadrack N, Kamau S, Karanja NN, Gachene CKK, Schulte-Geldermann E. "Agronomic assessment of phosphorus efficacy for potato (Solanum tuberosum L) under legume intercrops.". 2019.
DN Kareithi, Salifu D, N Owuor, Subramanian S, Tonnang EZH. "An algorithm for data reconstruction from published articles–Application on insect life tables." Cogent Mathematics & Statistics. 2019;6(1):1701377. AbstractWebsite

Data collection in life table experiments is generally time-consuming and costly such that data reconstruction of published information provides an avenue to access the original data for purposes of further investigation. In this paper, we present an algorithm that reconstructs life table raw data using a summary of results from published articles. We present the steps of the development and implementation (in the R computer language) of the algorithm, its scope of application, assumptions, and limitations. Statistical background of the algorithm is also presented. The developed algorithm was then applied to reconstruction of life table data of two insect species, Chilo partellus and Busseola fusca, from published information. Welch’s two-sample t-test was applied to test the difference between the original and reconstructed data of the insect life stages. C. Partellus results were not significantly different, but, for B. fusca, pupa development time, and larva and pupa development rate were significantly different at the 95% confidence level. It is concluded that the algorithm could be used to reconstruct original data sets from cohort life table data sets of insects, given published information and sample sizes.

Alionja Asali na Hadithi Nyingine . Nairobi: Focus publishers; 2019.
Mutembei H, Tsuma V, Kios D. "Alternative Follicle Stimulating Hormone Dose Rate for Embryo Production in Dairy Cattle." Journal of Dairy & Veterinary Sciences. 2019;10(3):1-7.mutembei-kios_2019.pdf
Ondiek MA, Moturi CA. "An An assessment of the sustainability of Living Labs in Kenya." Innovation & Management Review. 2019;16(4):391-403. Abstract10-1108_inmr-08-2018-0058.pdf

Purpose – There has been a high rate of failure among the Living Labs in Kenya resulting in the expected
outcomes not fully realized. This paper aims to assess the sustainability of Living Labs in Kenya.
Design/methodology/approach – Based on the four capital method of sustainable development evaluation framework, data were collected through interviews and questionnaires from innovators, users and employees among the 25 living labs in Kenya.
Findings – The research found that some innovators are not familiar with the living labs, the living labs are innovative and prepared to survive in future, some labs have strategic plans on how to pursue future environment and have developed ways of choosing right people to incubate, inability to get enough funding from the host organizations and limited knowledge on the supervision level of the operations. A model is proposed that can be generalized to other living labs in developing countries.
Research limitations/implications – The study was done in Nairobi where most of the living labs are situated.
Practical implications – The study concludes by emphasizing on the user involvement during innovation process. There is need to expand the capacities of living labs to accommodate more people to ensure more innovations are supported at a time. The senior managers in charge of the living labs should increase the level of supervision to ensure that the labs are effective in their incubation efforts and institutionalize support of the host organization to the labs to ensure continued growth and expansion.
Originality/value – The findings of this study are of value to research community, the decision and policymakers as it seeks to document the current status of the living labs in the Kenya
Keywords Sustainableinnovation,Livinglabs,Innovationecosystem,Innovationlab, Innovation space, User-driven innovation

KJ G, AM M, GO A’. "ANAEMIA AMONG BREASTFEEDING INFANTS (0-6 MONTHS) AND ASSOCIATED FACTORS IN A LOW INCOME URBAN SETTING OF KENYA." African Journal of Food , Agriculture,Nutrition and Development. 2019;19(2):14303-14319.
E.A O, P.G N, P.K N. "Anaerobic Co-Digestion of Water Hyacinth (E. crassipes) With Ruminal Slaughterhouse Waste for Biogas Production." Int. Journal of Renewable Energy Development. 2019;8(3):253-259.
Maina J, Wandiga S, Gyampoh B, KK GC. "Analysis of Average Annual Rainfall and Average Maximum Annual Temperature for a Period of 30 years to Establish Trends in Kieni, Central." Journal of Climatol Weather Forecasting. 2019;7:249. Abstractwww.longdom.org

The aim of the study was to analyze average annual rainfall and average maximum annual temperature records for
30 years in the study area to establish trends hence confirm the presence or absence of climate change. The analysis
was accomplished with the use of MS Excel spreadsheets. The meteorological datasets were 1984-2013 records for
rainfall and 1981-2012 for temperature. The rainfall climatological standard normal was computed for a 25-year
period between 1989 and 2012 which was used to compute the average annual rainfall anomaly. The temperature
provisional normal was computed for a period of 10 years due to lack of adequate data. The average annual rainfall
anomaly for 1984-2013 periods was -8.8 mm an indication of a declining rainfall trend while the annual maximum
temperature for 1981-2012 period was 0.5°C a positive trend showing that the annual maximum temperatures
are rising in the study area. Therefore, the declining average annual rainfall accompanied with rising maximum
temperatures were indicators of the presence of climate change.

Keywords: Average annual rainfall; Average maximum temperature; Trends; Climatological standard normal;
Datasets; Climate change

Susan Gachau, Nelson Owuor, NJAGI EDMUNDNJERU, Ayieko P, English M. "Analysis of Hierarchical Routine Data With Covariate Missingness: Effects of Audit & Feedback on Clinicians' Prescribed Pediatric Pneumonia Care in Kenyan Hospitals." Frontiers in public health. 2019;7( ):198. AbstractWebsite

Background:
Routine clinical data are widely used in many countries to monitor quality of care. A limitation of routine data is missing information which occur due to lack of documentation of care processes by health care providers, poor record keeping or limited health care technology at facility level. Our objective was to address missing covariates while properly accounting for hierarchical structure in routine paediatric pneumonia care.
Methods:
We analysed routine data collected during a cluster randomized trial to investigating the effect of audit and feedback (A&F) over time on inpatient pneumonia care among children admitted in 12 Kenyan hospitals between March and November 2016. Six hospitals in the intervention arm received enhance A&F on classification and treatment of pneumonia cases in addition to a standard A&F report on general inpatient paediatric care. The remaining six in control arm received standard A&F alone. We derived and analysed a composite outcome known as Paediatric Admission Quality of Care (PAQC) score. In our analysis, we adjusted for patients, clinician and hospital level factors. Missing data occurred in patient and clinician level variables. We did multiple imputation of missing covariates within the joint model imputation framework. We fitted proportion odds random effects model and generalized estimating equation (GEE) models to the data before and after multilevel multiple imputation.

and I DKECM. "An Analysis of Internal Efficiency in Primary School Education in Western Equatoria State of South Sudan between 2009 and 2013." International Journal of Educational Science and Research (IJESR). 2019;9(1).
Olali T, Karani R. "Analyzing the Perspectives and Strategies in Localizing Software in Kiswahili." International Journal of Applied Linguistics and Translation. . 2019;5(1):15-20.

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