Human Leucocyte Antigens (DRB1 *03, DRB1*04 and DQB1*02) Associated with Type 1 Diabetes Mellitus among 269 Kidney Graft Donors and Recipients in Kenya

Citation:
Kabinga DSK, O DAJ, Bhatt PKM, Kayima PJK, McLigeyo PSO. "Human Leucocyte Antigens (DRB1 *03, DRB1*04 and DQB1*02) Associated with Type 1 Diabetes Mellitus among 269 Kidney Graft Donors and Recipients in Kenya." International Journal of Sciences: Basic and Applied Research (IJSBAR). 2016:57-63.

Abstract:

This was a descriptive study which utilized the medical record
s for the kidney donors and recipients who had
been followed up
in
the kidney transplantation programme in Kenyatta National Hospital, Nairobi, Kenya.
Tissue typing is rarely performed routinely among our patients partially due to cost. It is with this in
mind that
we engaged in extraction of more information from the tissue typing data which have been used in kidney
transplantation programme in Kenyatta National Hospital, Nairobi Kenya. The data were extracted from the
medical records of patients who had undergone tissue typing for renal transplantation and were on follow up at
Kenyatta National Hospital. The study had been cleared by the Kenyatta National Hospital/University of
Nairobi Ethics Research Committee, number, P485/9/2013.
The medical records had tissue typing done from 2008 and 2013.
A total of 269 individuals’ human leucocyte
antigen typing were
utilized
. They comprised 134 kidney graft recipients
and 135 donors records
. T
he typing
had been performed using
serology
for class I and polymerase chain reaction for Class II respectively. The data
were analysed using Statistical Program for Social Sciences, calculating the frequencies of each individual for
HLA specificity and expressing it as a percentage of the total popu
lation of 269 individuals. For s
ome genes and
alleles associated
with
type 1 diabetes (
DRB1
*03, DRB1*04 and DQB1*02)
, there were 184/269 (68.4%) of
individual
s who carried genes and al
leles.
Eighty four (84) individuals had HLA
-DRB1*03 allele, 22 had
DRB1*04 while 78 had DQB1*02. Among 135 kidney graft donors, 39 (28.90%) carried HLA
-DRB1*03 and
14 (10.40%) carried DRB1*04. Among 134 kidney graft recipients, 45 (33.57%) had HLA
-DRB1*03
and 13
(9.70%) had HLA
-DRB1*04. Thirt
y-six (26.87%) had HLA
-DQB1*02.
There is increase in the prevalence of diabetes mellitus among other non
-communicable condition
s world over.
Diabetes has both nature and nurture as players for its causation. Genetics w
hich include human leucocyte
antigens have been liked with diabetes. Among our study population, HLA
-DRB1
*03, HLA
-DRB1*04 and
HLA-
DQB1*02 were prevalent and this may guide surveillance and care for both donors and recipients, as well
as inform the
care of our wider population.

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