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KARUOYA PROFGITAUGEORGE. "7. E.G. Kiarie, L.W. Kabuage, G.K. Gitau, J.W. Wakhungu, J. Githure and C.M. Mutero. Description of livestock and their role in Mwea irrigation scheme. Bulletin of Animal Health and Production in Africa (2006) 54: 110-117.". In: Trop Anim Health Prod (2010) 42:1643-1647. Bulletin of Animal Health and Production in Africa; 2006. Abstract

Abstract The study reported data from 507 post-mortem records in the Department of Pathology, Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Nairobi, Kenya. The records were from carcasses obtained from the peri-urban area of airobi during a 20-year period between 1990 and 2009. Approximately 80% (393/507) of the calf carcasses had their diagnosis made through post-mortem examination, while the rest (114/507) were incon-clusive. Just less than half (48.3%) of the calf carcasses presented had their age specified by the owners compared to 51.7% whose age was not specified. For calf carcasses whose age was specified by the owners, those indicated as more than 3 months were one-and-a-half times as many as those below 3 months old. The proportion of female carcasses (53.8%, 273/507) presented for post-mortem were slightly higher than the male carcasses (46.2%, 234/507). Diseases or conditions of the respiratory system were the most common 17.7% (97/507) while gastrointes- tinal tract (GIT) was second and affected 16.1 % (88/507) of the cases. Another small number, 3.3% (18/507), died from bloat giving the total cases associated with GIT as 19.4% (106/507). Severe calf malnutrition and septicaemia were the third most reported causes of calf mortality in similar proportions at 14.3% (78/507) and 14.4% (79/507), respectively. Other minor causes of calf mortality were tick-borne diseases 8.6% (47/507), helminthiasis and poisoning, 2.9% (16/507) and 1.8% (10/507), respectively.

Gor SO. "7. Industrial Structure, the Nature of Informal Enterprise and Inequality in Kenya: A Dominance Analysis.". In: AIM-IARIW Special Conference on Measuring the Informal Economy in Developing Countries. Kathmandu, Nepal; 2009.
P. OCHILO. "7. Press Freedom and The Functions of the Media in Kenya." the Journal of Africa Media Review . 1993;Volume 7 (No. 3 – December, 1993).
Mwega F. "7. `The Short-run Shifting of the Manufacturers' Sales Taxes in Kenya: Revisited'." Eastern Africa Economic Review. 1988;4(5).
Mwaliwa HC. "7. ‘Nafasi ya Kiswahili Sanifu katika Stesheni za Televisheni Nchini Kenya.". In: Ukuzaji wa Kiswahili : Dhima na Majukumu ya Asasi Mbalimbali . Nairobi: Focus Publishers Limited; 2014.
KIIRU PROFMUCHUGUDH. "720 Hours in This Scept.". In: The Journal African Travel-Writing 8-9 (2001): 106-19. Philosophical Issues Invoked by Shona People; 2001. Abstract

Yenesew A, Mushibe EK, Induli M, Derese S, Midiwo JO, Kabaru JM, Heydenreich M, Cock A, Peter MG. "7a-O-methyldeguelol, a modified rotenoid with an open ring--C, from the roots of Derris trifoliata." Phytochemistry. 2005;66:653-657.
DR. KABARU JACQUESM. "7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.". In: Massachusetts. CABI. Pp 209. African Meteorological Society; 2005. Abstract
Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} From the acetone extract of the roots of Derris trifoliata an isofiavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isofiavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata.
SOLOMON DRDERESE. "7a-O-Methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata." Phytochemistry. 2005;66:653-657. AbstractWebsite

Phytochemistry. 2005 Mar;66(6):653-7.

7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.

Yenesew A, Mushibe EK, Induli M, Derese S, Midiwo JO, Kabaru JM, Heydenreich M, Koch A, Peter MG.

From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata.

Yenesew A. "7a-O-Methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.." Phytochemistry . 2005;66:653-657. Abstractpaper_36_yenesew_et_al_phyto_2005_66_653.pdf

From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and a-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata.

DR. KABARU JACQUESM. "7a-O-methyldequelol, a modified rotenoid with an open ring-C from the roots of derris trifolianta Phytochemistry, Vol. 66, 653-657.". In: Massachusetts. CABI. Pp 209. African Meteorological Society; 2005. Abstract
Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone.
"The 7th Conference of the Parties to the UNCCD.". In: Conference of the Parties to the UNCCD. Nairobi, Kenya.; 2005.
Keiyoro, P.N., Kinuthia, Ngunjiri. 7th International conference on ICT for Development, Education and Training in Africa. Cotonou Benin; 2012.
O PROFNYINGUROPHILIP. "7th March, 2007 .". In: United Nations Centre for Regional Development, AICAD, Juja, Kenya.; 2007. Abstract
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"The 7th Meeting of the Subsidiary Body on the Scientific Technical and Technological Advice (SBSTTA – 7) of the Convention on Biological Diversity (CBD).". In: Subsidiary Body on the Scientific Technical and Technological Advice (SBSTTA – 7) of the Convention on Biological Diversity (CBD). Montreal, Canada.; 2001.
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Akech M. 8) Facilitating and Monitoring the Implementation of the New Constitution. African Centre for Open Governance; 2010.
Akech M. "8) FIFA’s Role in Governance of Football in Kenya.". In: Resolving the Dilemma of Non-Intervention.; 2010.
DOROTHY MRSOMOLLO. "8-4-4 system of education and the teaching of English The way forward Research Paper. presented at the international conference on communication and education, Nairobi, 1992.". In: J Infect Dis. 1992 Aug;166(2):359-64. Earthscan, London. 978-1-84407-469-3 (*); 1992. Abstract

Division of Bacterial and Mycotic Diseases, Centers for Disease Control, Atlanta, GA 30333. An epidemic of meningococcal disease occurred in Nairobi, Kenya, during 1989, outside the "meningitis belt" of sub-Saharan Africa. About 3800 cases occurred between April and November (250/100,000 population). The case-fatality rate was 9.4% among hospitalized patients. Areas that included Nairobi's largest slums had particularly high attack rates. The epidemic displayed an unusual age distribution, with high attack rates among those 20-29 years old. A vaccination campaign was conducted. By early January, the weekly case count had fallen to 25 from a high of 272 (in September). A case-control study estimated the vaccine efficacy to be 87% (95% confidence interval, 67%-95%). A model estimated that the vaccination campaign reduced the number of cases by at least 20%. Multilocus enzyme electrophoretic typing demonstrated that the strain responsible for this large epidemic is closely related to strains that caused other recent epidemics, documenting further spread of what may be a particularly virulent clonal complex of group A Neisseria meningitidis.

WAIRIMU PROFKIBERALUCY. "The 8-4-4 system on Education and its implications on career and educational aspirations of students.". In: Staff Seminar Paper to the Department of Educational Foundations. AIDS 24(6):891-7; 1990. Abstract
  
Yenesew A, N A, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler H-G, Sewald N. "8-Hydroxy-6-methylxanthone-1-carboxylic acid and 6',8-O-dimethylknipholone from the roots of Bulbine frutescens." Phytochemistry Letters . 2014;9:67-73. Abstractpaper_70_abdissa_et_al_phyto_2014.pdf

Phytochemical investigation of the dichloromethane/methanol (1:1) extract of the roots of Bulbine frutescens led to the isolation of a new xanthone, 8-hydroxy-6-methylxanthone-1-carboxylic acid (1) and a new phenylanthraquinone, 6′,8-O-dimethylknipholone (2) along with six known compounds. The structures were elucidated on the basis of NMR and MS spectral data analyses. The structure of compound 1 was confirmed through X-ray crystallography which was then used as a reference to propose the revision of the structures of six seco-anthraquinones into xanthones. The isolated compounds were evaluated for cytotoxicity against human cervix carcinoma KB-3-1 cells with the phenylanthraquinone knipholone being the most active (IC50 = 0.43 μM). Two semi-synthetic knipholone derivatives, knipholone Mannich base and knipholone-1,3-oxazine, were prepared and tested for cytotoxic activity; both showed moderate activities (IC50 value of 1.89 and 2.50 μM, respectively).

M.N. M. "8-METHOXYNEORAUTENOL AND RADICAL SCAVENGING FLAVONOIDS FROM ERYTHRINA ABYSSINICA." Bulletin of the Chemical Society of Ethiopia. 2009;23(2):205-210. Abstract

A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the
root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and
shinpterocarpin were identified for the first time from the roots of this plant. The structures were determined on
the basis of spectroscopic evidence. The new compound showed selective antimicrobial activity against
Trichophyton mentagrophytes. The acetone extract of the root bark of E. abyssinica showed radical scavenging
activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-
dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the standard quercetin.

NJOGU DRMBUGUAMARTIN. "8-Methoxyneorautenol and Radical Scavenging flavonoids from Erythrina abyssinica.". In: Bulletin of the Chemical Society of Ethiopia, 23(2), 001-006. Bulletin of the Chemical Society of Ethiopia, 23(2), 001-006.; 2009. Abstract
ABSTRACT. A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and shinpterocarpin were identified for the first time from the roots of this plant. The structures were determined on the basis of spectroscopic evidence. The new compound showed selective antimicrobial activity against Trichophyton mentagrophytes. The acetone extract of the root bark of E. abyssinica showed radical scavengingactivity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3- dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the standard quercetin.
Yenesew A. "8-Methoxyneorautenol and Radical Scavenging flavonoids from Erythrina abyssinica." Bull. Chem. Soc. Ethiopia . 2009;23:205-210. Abstractpaper_47_yenesew_et_l_bull_chem_soc_ethiop-2009-23-205.pdf

A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the
root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and
shinpterocarpin were identified for the first time from the roots of this plant. The structures were determined on the basis of spectroscopic evidence. The new compound showed selective antimicrobial activity against
Trichophyton mentagrophytes. The acetone extract of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the standard quercetin.

KEY WORDS: Erythrina abyssinica, Root bark, Leguminosae, Pterocarpan, 8-Methoxyneorautenol,
Pterocarpenes, 3-Hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene, Erycristagallin, Antimicrobial, Radical scavengers, DPPH

Gor SO. "8. A New Approach to the Measurement of Wellbeing: A Technical Note.". In: General Conference of The International Association for Research in Income and Wealth. Portoroz, Slovenia; 2008.
KARUOYA PROFGITAUGEORGE. "8. Karimi S.K., G.K. Gitau, J.J. McDermott, R.N. Kinuthia, J.M. Gathuma. Estimation of birth weight of Maasai Zebu calves and their crosses with Sahiwal and Boran in Kajiado District, Kenya. Bulletin of Animal Health and Production in Africa (2005) 53: 35.". In: Trop Anim Health Prod (2010) 42:1643-1647. Bulletin of Animal Health and Production in Africa; 2005. Abstract

Abstract The study reported data from 507 post-mortem records in the Department of Pathology, Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Nairobi, Kenya. The records were from carcasses obtained from the peri-urban area of airobi during a 20-year period between 1990 and 2009. Approximately 80% (393/507) of the calf carcasses had their diagnosis made through post-mortem examination, while the rest (114/507) were incon-clusive. Just less than half (48.3%) of the calf carcasses presented had their age specified by the owners compared to 51.7% whose age was not specified. For calf carcasses whose age was specified by the owners, those indicated as more than 3 months were one-and-a-half times as many as those below 3 months old. The proportion of female carcasses (53.8%, 273/507) presented for post-mortem were slightly higher than the male carcasses (46.2%, 234/507). Diseases or conditions of the respiratory system were the most common 17.7% (97/507) while gastrointes- tinal tract (GIT) was second and affected 16.1 % (88/507) of the cases. Another small number, 3.3% (18/507), died from bloat giving the total cases associated with GIT as 19.4% (106/507). Severe calf malnutrition and septicaemia were the third most reported causes of calf mortality in similar proportions at 14.3% (78/507) and 14.4% (79/507), respectively. Other minor causes of calf mortality were tick-borne diseases 8.6% (47/507), helminthiasis and poisoning, 2.9% (16/507) and 1.8% (10/507), respectively.

P. OCHILO. "8. The Role of the Media in the Prevention and Control of AIDS in Africa.". In: The AIDS Epidemiology and Control Seminar .; 1988.
Mwega F, Due J, Osoro N. "8. `Evolving Sales Taxation in Kenya and Tanzania'." Bureau of International Fiscal Documentation. 1990:233-239.
Mwaliwa HC. "8. ‘Nafasi ya Kiswahili katika Kueneza Shughuli za Kidini’ .". In: Kiswahili na Maendeleo ya Jamii. Dar es salaam: TUKI; 2015.
OPIYO PROFAKECHNOBERT. "8. Muhongo S. and N. Opiyo-Akech , 1999 - Geology and mineral resources of east Africa:.". In: Journal of African Earth Sciences Vol.29, Issue 2. pp 281-282. UNIVERSITY OF NAIROBI; 1999. Abstract
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Chohan BH, Froggett S, Emery S WD, G J-S, Majiwa M, Ng'ayo M, J. O. "8.Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting." BMC Pediatr. 2011 Feb 18;11:18. doi: 10.1186/1471-2431-11-18.. 2011. Abstract

Abstract
BACKGROUND:
The aim of this study was to develop an economical 'in-house' single round polymerase chain reaction (PCR) assay using filter paper-dried blood spots (FP-DBS) for early infant HIV-1 diagnosis and to evaluate its performance in an African setting.
METHODS:
An 'in-house' single round PCR assay that targets conserved regions in the HIV-1 polymerase (pol) gene was validated for use with FP-DBS; first we validated this assay using FP-DBS spiked with cell standards of known HIV-1 copy numbers. Next, we validated the assay by testing the archived FP-DBS (N=115) from infants of known HIV-1 infection status. Subsequently this 'in-house' HIV-1 pol PCR FP-DBS assay was then established in Nairobi, Kenya for further evaluation on freshly collected FP-DBS (N=186) from infants, and compared with findings from a reference laboratory using the Roche Amplicor® HIV-1 DNA Test, version 1.5 assay.
RESULTS:
The HIV-1 pol PCR FP-DBS assay could detect one HIV-1 proviral copy in 38.7% of tests, 2 copies in 46.9% of tests, 5 copies in 72.5% of tests and 10 copies in 98.1% of tests performed with spiked samples. Using the archived FP-DBS samples from infants of known infection status, this assay was 92.8% sensitive and 98.3% specific for HIV-1 infant diagnosis. Using 186 FP-DBS collected from infants recently defined as HIV-1 positive using the commercially available Roche Amplicor v1.5 assay, 178 FP-DBS tested positive by this 'in-house' single-round HIV-1 pol PCR FP-DBS PCR assay. Upon subsequent retesting, the 8 infant FP-DBS samples that were discordant were confirmed as HIV-1 negative by both assays using a second blood sample.
CONCLUSIONS:
HIV-1 was detected with high sensitivity and specificity using both archived and more recently collected samples. This suggests that this 'in-house' HIV-1 pol FP-DBS PCR assay can provide an alternative cost-effective, reliable and rapid method for early detection of HIV-1 infection in infants.

Upadhyaya MK, Toivonen PMA. "85 Flower formation in Primula vulgaris.". 2002.Website
"The 8th Conference of Parties to CBD.". In: Conference of Parties to CBD . Curitiba, Brazil; 2006.
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Akech M, Kameri-Mbote P. 9) Kenyan Courts and Politics of the Rule of Law in the Post-Authoritarian State. Helsinki : the Institute of Development Studies, University of Helsinki ; 2009.
Akech M. "9) PRIVATIZATION AND DEMOCRACY IN EAST AFRICA.". In: THE PROMISE OF ADMINISTRATIVE LAW .; 2009.
P. OCHILO. "9. A Review of Health Communication Exercised by Mass Media in Kenya.". In: the Training Course of East African Journalists on Primary Health Care. Dar-es-Salaam, Tanzania; 1987.
KARUOYA PROFGITAUGEORGE. "9. C.M. Mutero, C. Kabutha, V. Kimani, L. Kabuage, G. Gitau, J. Ssennyonga, J. Githure, L. Muthami, A. Kaida, L. Musyoka, E. Kiarie and M. Oganda. A transdisciplinary perspective of the links between malaria and agroecosystems in Kenya. Acta Tropica (2004.". In: Trop Anim Health Prod (2010) 42:1643-1647. Acta Tropica; 2004. Abstract

Abstract The study reported data from 507 post-mortem records in the Department of Pathology, Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Nairobi, Kenya. The records were from carcasses obtained from the peri-urban area of airobi during a 20-year period between 1990 and 2009. Approximately 80% (393/507) of the calf carcasses had their diagnosis made through post-mortem examination, while the rest (114/507) were incon-clusive. Just less than half (48.3%) of the calf carcasses presented had their age specified by the owners compared to 51.7% whose age was not specified. For calf carcasses whose age was specified by the owners, those indicated as more than 3 months were one-and-a-half times as many as those below 3 months old. The proportion of female carcasses (53.8%, 273/507) presented for post-mortem were slightly higher than the male carcasses (46.2%, 234/507). Diseases or conditions of the respiratory system were the most common 17.7% (97/507) while gastrointes- tinal tract (GIT) was second and affected 16.1 % (88/507) of the cases. Another small number, 3.3% (18/507), died from bloat giving the total cases associated with GIT as 19.4% (106/507). Severe calf malnutrition and septicaemia were the third most reported causes of calf mortality in similar proportions at 14.3% (78/507) and 14.4% (79/507), respectively. Other minor causes of calf mortality were tick-borne diseases 8.6% (47/507), helminthiasis and poisoning, 2.9% (16/507) and 1.8% (10/507), respectively.

KAISHA DROTSIANYIWYCKLIFFE. "9. The femoral collodiaphyseal angle amongst selected Kenyan ethnic groups. Kaisha W, Pulei A, Koech A. Journal of morphological sciences.". In: Int. J. Morphol. Journal of Morphological sciences; 2011.
P. OCHILO. "9. The Media: Professional Independence and Fair Coverage of Elections Published in: Kenya Journal of Sciences: Series C. Humanities and Social Sciences ." Kenya Journal of Sciences: Series C. Humanities and Social Sciences . 1997;Volume 4 (No.1).
9. Transition from Early childhood Education to Primary . Kisumu: Ministry of Education; 1999.
Mweha F, Mwangi N, Ngola S. "9. `Real Interest Rates and the Mobilization of Private Savings in Africa: The Case of Kenya'." Ile Ife Journal of Economics and Finance. 1991;1(1).
Nanyingi MO, Mbaria JM, Okello RO, Wagate CG, Lanyasunya AL, Kipsengeret B Koros, M.Oguna M. "9.131 Evaluation of resistance development to three anthelmintics and efficacy of plant extracts against nematodes of sheep in Samburu District, Kenya .". In: KVA Scientific Seminar.; 2008.
MUCHAI PROFKAGIKOM, MWANGI PROFGATHUMAJ. "93.Maingi, N.,Gichohi, V.M.,Munyua. W.K., Gathuma,J.M. and Thamsborg, S.M. (1997). The epidemiology of nematode and liverfluke infections in sheep in Nyandarua District of Kenya. Bull. Anim. Hlth. Prod. Afri. 45, 27-34.". In: journal. FARA; 1997. Abstract
Bacillus cereus strains were tested for production of diarrheal enterotoxin by the reverse passive latex agglutination test and for presence of B. cereus enterotoxin gene (bceT) by polymerase chain reaction. About 50% of 56 B. cereus strains reacted positive in broth culture in the reverse passive latex agglutination test, while the bceT gene was detected in 41.1 % of the strains. A 741 bp probe prepared from the polymerase chain reaction product detected bceT gene in all strains that were positive with the polymerase chain reaction. This study indicated a likelihood of two or more enterotoxins being produced by B. cereus which may be involved in causing diarrheal type food poisoning.
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Mwangi JT. ": A Study of the Quality of Facilities that Exist for the Teaching of O – Level Chemistry in Some Selected Secondary Schools in Mbiri Constituency of Murang’a District. .". 1986. Abstract

THE ABSTRACT
The primary task of this study was to investigate perceptions of the quality of the available facilities for the teaching of O – Level chemistry in some selected secondary schools by Chemistry teachers in Mbiri constituency of Murang’a district. The study was limited by among others: Firstly, it was carried out only in one area, Mbiri constituency. This will therefore not allow generalization the district, let alone to all secondary schools in Kenya. Secondly, the amount of money and time for this project, limited this project since it was too little to allow the researcher use a large sample. The project was therefore limited to 10 secondary schools randomly selected in the constituency. The 16 chemistry teachers from the selected schools served as the subjects for this project.
The major tool used in this study was a questionnaire which was personally administered by the researcher to the 16 chemistry teachers. The data collected was analysed using descriptive statistics. Percentages were used to determine the chemistry teachers’ perceptions of the quality of the available chemistry facilities. After analyzing the data it was apparent that:
(i) O – level chemistry teaching facilities are inadequate in these schools.
(ii) The shortage of these facilities is quickly becoming more acute owing partly to the increase of school enrolment and partly due to the increasing percentage of pupils taking up chemistry.
(iii) It was found out that even though these facilities were limited, the few that there are, are normally not used optimally.
(iv) Other major revelations from the study are constraints associated with the teaching of O – Level chemistry.
On the basis of the findings the researcher recommends the following among many others.
(i) The Ministry of Education, Science and Technology should step in and help to reduce the disparity of facilities between the government aided and harambee schools.
(ii) There should be regular seminars for all chemistry teachers at district level.
(iii) There is a real need to construct new science blocks in the near future at the established and upcoming schools.

Gateri MW, Opere AO, Gitau W. ": Domestic Rainwater harvesting in Kilifi, Taita-Taveta and Mombasa Counties." J. Meteorol. Relat. Sci. . 2016;DOI: 10.20987/jmrs .
Agwanda A. : Kenya Country Millennium Development Goals (MDG) Needs Assessment Report on Child health, Maternal health and Health Systems. . Ministry of Planning and National Development, Government of Kenya and UNDP; 2004.
Noordin R, Whitbrodt M, Waris A. ": Law and Economics: A New Dimension in Market Regulation (co-authored with and )." International Business Management. 2012.
KAGURE PROFKARANIANNE. ": PERCEPTION OF BACHELOR OF SCIENCE IN NURSING (BScN) ON THEIR ROLE ON NURSING IN A HOSPITAL SETTING Prof. Anna K. Karani University of Nairobi, Stephen Kainga,(MScN) University of Nairobi Prof. Simon Kangethe Moi University. Diana Mwarania BScN (graduate.". In: Kenya Nursing Journal: Dec. KNJ Vol. 41(2) 23-33. Impress Communications; Submitted. Abstract

The study was conducted to investigate the clinical Competence of Bachelor of Science Nursing graduates working at Kenyatta National Hospital in March 2011. The objective was to assess the perceptions of graduate nurses about the nursing profession and the implications on the development of BScN undergraduates from the University of Nairobi and other Universities with a view to improving their perception about the profession  through continuing education and curriculum review. It was a cross sectional study with a sample size of 50 nurses, total population selected on purpose. A supervised questionnaire and focus group discussion tools were used for data collection.  The findings indicated that majority of the Bachelor of Science Nursing graduates

Wambugu, M, Nyandega I, Kithia S. ": Spatio-Temporal Dynamics of Land Use Practices on Rivers in Tropical Regions: A case Study of Ruiru and Ndarugu Basins, Kiambu County, Kenya." African Journal of Environmental Science and Technology. 2017;11(8):426-437.
Kaviti L. ": The new curriculum of Education in Kenya: A Linguistic and Education Paradigm shift. ." In the Journal of Humanities and Social Sciences peer reviewed reviewed by the international organization of Scientific Research International Journal of Scien. 2018.
CHEPCHIENG J, KYALO DN, MULWA SA. ": ‘The Influence Of Urban Transport Policy On The Growth Of Motorcycle And Tricycles In Kenya’ .". In: The 3rd African International Business And Management . Conference K.I.C.C, Nairobi, Kenya.; 2012.
Mbuthia E-EM. : “Fimbo ya Mbali na Hadithi Nyingine. Nairobi: ''Fimbo ya Mbali na hadithi Nyingine; 2016.
Mbuthia DEM. ": “Kiswahili na Vyombo vya Habari”.". In: ''Kiswahili kwa mahitaji Maalum''. Mombasa; 2000.
Njoroge HG. : “Mwingilianomatini katika Fasihi ya Kiswahili: Tata za Asumini Na Rosa Mistika. E.M. DM, Olali DT, eds. Nairobi: University of Nairobi; 2007.
Nyonje. : “Mwono Ulimwengu wa Waswahili” . E.M. DM, ed. Nairobi: University of Nairobi; 2006.
Kisiroche. IR. : “Sauti ya mwanamke dhidi ya Ubabedume katika tamthilia tatu za Kiswahili’’ . E.M. DM, K.W PW, eds. Nairobi: University of Nairobi; 2008.
Mulama. SJ. : “Usimulizi katika Utenzi wa Siri Li Asirali’’. K.W. PW, ed. Nairobi: University of Nairobi; 2011.
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HENRY PROFINDANGASI. ""A Bold Fearless Account of Kenya's Recent Political History", A Review of Joseph Karimi and Philip Ochieng, The Kenyatta Succession, Nairobi (Transafrica) 1980, 195 pages, in Nairobi Times.". In: (Published in Japanese). GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1980. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
AKATCH PROFSAMUELO. ""A Case for Improved Housing" Construction Review Journal of the Construction Industry, Vol. 13 No. 10 pp. 53-55 January 2003.". In: Federation Proceedings, 31 1470. Journal of Natural Products; 2003.
KIIRU PROFMUCHUGUDH. ""A Case for Stylistics in Literary Scholarship: Review of Niyi Osundare, Cautious Paths through the Bramble" The Nairobi Journal of Literature 4 (March 2006): 83-89.". In: The Nairobi Journal of Literature 4 (March 2006): 83-89. Philosophical Issues Invoked by Shona People; 2006. Abstract

This paper presents a case for the need to build a virtual bibliography of Kenyan literature on the World Wide Web; this catalogue without cards will present to the wide audience with access to the internet basic and correct information on this literature. In the course of discussing the place of modern information technology in the world, the paper discusses the Kenyan literary heritage as a form of higher culture reflecting social experiences, capturing the souls of the nation and encapsulating the high ideals of humanism and progress. Further, the paper calls for honesty and sensitivity in the preservation of information on the literary texts, lest this information is laid open to possible distortion, even manipulation, by those who post it on the World Wide Web. Implicitly, the paper makes a case for the need of the developing world

MWIGA PROFMWABUGERMANO. ""A Comment on Kenyan Migration Movement", Eastern Africa Economic Review, 3:2, pp. 143-145.". In: Proceedings Sixth College on Thin Film Technology, July 24th . University of Nairobi; 1989. Abstract
The role of pastoralist women in conflict resolution and management (study funded by SIDA though IMPACT)
OKECH MROWITIMAURICED. "'A Concept Brief on Methodologies of "Mass" Civic Education for Constitutional Review'.". In: Victoria Walter and Debbie Betts (eds), Safeguarding Human Rights in Eastern Africa (FES, Kampala), 77. Rao, W. O., Ogonji, J. A.. and Aywa, S.; 1999. Abstract
PIP: This research report studies several biochemical and histochemical aspects of cervical carcinoma and explores their use in follow-up of patients undergoing radiotherapy. Material came from 19 patients with invasive cervical carcinoma admitted to Kenyatta National Hospital. A control group consisted of 20 women matched for age who attended clinics at the hospital but were not suffering from any malignant disease; control tissue for histological examination was obtained from 3 women who had undergone hysterectomy for uterine fibroids. Biochemical assays for alkaline and acid phosphatases in patients with cervical carcinoma show an increase in alkaline phosphatase in carcinomatous tissue (35.7 umoles/hr/mg) as opposed to normal tissue (7.2). Acid phosphatase values were only moderately raised. Assays of the same enzymes in blood showed a less marked difference between patients and controls (ranges of 7.5-20.8 and 3-14, respectively). When examined histochemically, increased alkaline phosphatase activity was observed in connective tissue, epithelium of the glands and blood capillaries of tumor tissue. 1 section containing normal tissue bordering carcinomatous tissue demonstrated normal alkaline phosphatase activity in the normal tissue and increased activity in the tumor tissue. In summary, there is increased enzyme activity around the tumor areas, but values for serum levels show an overlap of normal and abnormal cases and are therefore not predictive. Results demonstrate a clear difference in activities of these enzymes in carcinomatous tissue and normal tissue, which may be of value in follow-up care.
A. DRSWAZURIMUHAMMED. ""A critical Look at Some Common Methods Used in Urban and Housing Research" paper presented to the International Conference on Housing Policy, Amsterdam, 27th June to 1st July, 1988.". In: Key issues for Developing Countries. 1992 Ed., Bhatnagar S.C., pp. 103-114. Tata-Mcgraw-Hill. African International Business and Management Conference, Nairobi, Kenya; 1988. Abstract
This article reveals that the concept of education as a process of growth is a difficult one. Philosophers are, therefore, justified in being weary when pondering over its meaning, both in theory and practice. By way of conclusion, the article appreciates the complexities inherent in the growth theory of education, summarizing its major strength and weaknesses. Then it cautions educational planners and practitioners to be weary when, and if, they translate the theory into practice, so that they utilize the strengths inherent in the theory whilst paying attention to the dangers of its inherent weaknesses.
OKOTH PROFOGENDOHASTINGW. ""A Food and Nutrition Policy for Kenya" (with Siegfried Schornherr); paper for the Kenya Delegation to the United Nations Wolrd Food Conference, Rome, November 506, 1974, IDS Working Paper No. 242.". In: Academics Press, New york. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 1975. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
MARY MWIANDI. ""A historical Perspective of Indigenous Food Crops in Chuka Division, Tharaka-Nithi District" in the role of indigenous food crops in combating deforestation and land degradation: a case of Tharaka Nithi District.". In: Paper presented at the African Studies Association, Chicago. University of Nairobi Press, Open and Distance Learning; 1996. Abstract

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GODFREY PROFMURIUKI. ""A History of the Kikuyu to 1904", Ph.D. thesis, University of London.". In: In Hadith III, E.A Publishing House, Nairobi.; 1969. Abstract
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HENRY PROFINDANGASI. ""A Lesson from the Soviet Union", A Review of Chingiz Aitomotov's novel Farewell Gul'Sary in Busara II, 3, 44-49.". In: (Published in Japanese). GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1971. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
HENRY PROFINDANGASI. ""A Literary Supplement", Joliso 1, 2:1-10.". In: (Published in Japanese). GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1981. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
A. DRSWAZURIMUHAMMED. ""A Market Survey of Commercial Properties in Nairobi", a consultancy project undertaken for Milligan and Company Limited, December, 1992.". In: Key issues for Developing Countries. 1992 Ed., Bhatnagar S.C., pp. 103-114. Tata-Mcgraw-Hill. African International Business and Management Conference, Nairobi, Kenya; 1992. Abstract
This article reveals that the concept of education as a process of growth is a difficult one. Philosophers are, therefore, justified in being weary when pondering over its meaning, both in theory and practice. By way of conclusion, the article appreciates the complexities inherent in the growth theory of education, summarizing its major strength and weaknesses. Then it cautions educational planners and practitioners to be weary when, and if, they translate the theory into practice, so that they utilize the strengths inherent in the theory whilst paying attention to the dangers of its inherent weaknesses.
MWIGA PROFMWABUGERMANO. ""A Model of Occupational Choice Applied to Rural Kenya," (with Robert E. Evenson), African Development Review, 9:2(1997), pp. 7-14.". In: Proceedings Sixth College on Thin Film Technology, July 24th . University of Nairobi; 1997. Abstract
The role of pastoralist women in conflict resolution and management (study funded by SIDA though IMPACT)
W PROFMUTOROHENRY. ""A Nearest Neighbour Analysis of the Mijikenda Kaya Settlements on the Hinterland Kenya Coast", Kenya Journal of Sciences, Series C., Social Sciences, of the Kenya National Academy of Sciences Vol. 1.". In: Kenya Journal of Sciences, Series C., Social Sciences, of the Kenya National Academy of Sciences Vol. 1. Elsevier; 1988. Abstract

Settlement pattern studies are concerned with relics of human occupation in the past. In an archaeological record, these relics either appear in clusters or individually in the form of pestholes, house floors, house foundations or as middens. On aerial photographs and topographic maps relics of past human occupation can be identified by the presence of circular or rectangular depressional features and stunted vegetation cover in the midst of a flourishing vegetation community. Past human settlements can also be identified in actual field observation as ruins: building structures, walled fortresses, moats, monuments and mounds.

Irrespective of their nature and conditions of preservation, past settlements are a reflection of human behaviour through time and space. The archaeological evidence that is found preserved in them can shed much light on our knowledge of past culture. The essential archaeological problem in the analysis and interpretation of settlement, however, is that architectural remains and other settlement data cannot be understood simply by their description, distribution, cultural attribution and chronology - as they have been from the early anthropological work of Morgan (1881) and Mindeleff (1890) through the first large-scale regional archaeological syntheses, such as Childe's (e.g. 1934) in Europe and Willey (1953) in South America up to the common archaeological survey work of today.

With the influence of modern cultural ecology, geography and sociobiology, settle­ment analysis has been transformed into a concern with environmental and ecological processes. Settlements are part of a complex integration of culture and ecology within a regional environment. As a result, settlement analysis in archaeology must attend not only to the physical layout of the environment, but also to the social and historical aspects of environmental interaction.

NJOROGE MRMWEMAWILFRED. ""A New simplified and Reliable HEMT Modelling Approach Using Pinched Cold FET S-Paramcters", IEEE International Microwave Symposium, Boston, June 2000 (main author).". In: East Afr Med J. 1987 Apr;64(4):287-8. International Journal of Climatology; 2000. Abstract

Ninety seven patients were examined for dental caries using two standard methods: (a) clinical examination based on WHO Basic Methods Oral Health surveys and (b) radiographic examination. Clinical examination method under records caries by upto 40%. Such under recording may give an impression of a decreasing caries prevalence in epidemiological studies.

NJOROGE MRMWEMAWILFRED. ""A New simplified and Reliable HEMT Modelling Approach Using Pinched Cold FET S-Paramcters", IEEE International Microwave Symposium, Boston, June 2000 (main author).". In: East Afr Med J. 1987 Apr;64(4):287-8. International Journal of Climatology; 2000. Abstract

Ninety seven patients were examined for dental caries using two standard methods: (a) clinical examination based on WHO Basic Methods Oral Health surveys and (b) radiographic examination. Clinical examination method under records caries by upto 40%. Such under recording may give an impression of a decreasing caries prevalence in epidemiological studies.

HENRY PROFINDANGASI. ""A Percecuted Poet from the Far East", A Review of Cry the People and Other Poems, by Kim Chi Ha in Maktaba III, 2, 67-72.". In: (Published in Japanese). GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1976. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
KITHURE DRKINDIKI. ""A Preliminary Comment on th Independence of the Kenya National Commission on Human Rights".". In: In Volume 2 Number 2 East African Journal of Human Rights and Democracy p. 120-127. Vaccine 26:2788- 2795; 2004. Abstract

We describe the technique of splenic aspiration in 113 patients presenting with splenomegaly. It was used initially to establish a diagnosis, and in those patients with kala azar, to follow the response of the parasites to therapy until 'parasitological cure'. In all 671 aspirations were performed. No complications occurred in the 69 patients with active kala azar, who collectively had more than 600 aspirations. One patient in a moribund condition had a fatal haemorrhage. The aspirate suggested a lymphoma, confirmed at autopsy. In 68 of the 69 patients with active kala azar, the diagnosis was established at the first aspiration. The essentials of the technique are the use of a small calibre needle (21 G), and speed, the needle being in the spleen for less than a second, with the consequent procurement of a few drops of material only.

NJOROGE MRMWEMAWILFRED. ""A Spectral Subtraction Method for Noise Reduction in Speech Signals", IEEE African Conference, May 1996 (co.". In: East Afr Med J. 1987 Apr;64(4):287-8. International Journal of Climatology; 1996. Abstract

Ninety seven patients were examined for dental caries using two standard methods: (a) clinical examination based on WHO Basic Methods Oral Health surveys and (b) radiographic examination. Clinical examination method under records caries by upto 40%. Such under recording may give an impression of a decreasing caries prevalence in epidemiological studies.

NJOROGE MRMWEMAWILFRED. ""A Spectral Subtraction Method for Noise Reduction in Speech Signals", IEEE African Conference, May 1996 (co.". In: East Afr Med J. 1987 Apr;64(4):287-8. International Journal of Climatology; 1996. Abstract

Ninety seven patients were examined for dental caries using two standard methods: (a) clinical examination based on WHO Basic Methods Oral Health surveys and (b) radiographic examination. Clinical examination method under records caries by upto 40%. Such under recording may give an impression of a decreasing caries prevalence in epidemiological studies.

M. DRWASIKEADUA. "A. A. M. Wasike, W. Ogana: Periodic solutions of a system of delay differential equations for a small delay.". In: Journal of Science Research . Starmat Designers & Allied, Nairobi; 2003. Abstract
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M. DRWASIKEADUA. "A. A. M. WASIKE: An analytical and numerical study of a system of Linearly Two Coupled Oscillators with a time Lag in the coupling;.". In: Proceedings of the first conference of the Kenya Mathematical Society 1993: 27-28. Ed. Ogana & Mberia. Starmat Designers & Allied, Nairobi; 1993. Abstract
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M. DRWASIKEADUA. "A. A. M. Wasike: Periodic solutions of systems of delay differential equations.". In: Indian Journal of Mathematics Vol. 44 No. 1 95-117 (2002). Starmat Designers & Allied, Nairobi; 2002. Abstract
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M. DRWASIKEADUA. "A. A. M. Wasike: Synchronization and Oscillator death in diffusively coupled lattice oscillators.". In: International Journal of Mathematical Sciences Vol. 2 No. 1 (2003), 67-82. Starmat Designers & Allied, Nairobi; 2003. Abstract
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W. DRWAKHUNGUJACOB. "A. Abate, J.W. Wakhungu and E.R. Mutiga.(1992). Effects of nutrients supplementation on ruminant animal production and reproduction in Sub-Saharan Africa. Page 415.". In: a paper presented at the all africa conference on animal agriculture: achievements,challenges and prospects, November 23-27, 1992, Nairobi, Kenya. Institute of African Studies, University of Nairobi; 1992.
B. PROFESTAMBALEBENSON. "A. Blackwell, A.E Stuart, B.A. Estambale (2003). The repellent and antifeedant activity of Myrica Gale oil against Aedes aegypti mosquitoes and its enhancement by the addition of salicyluric acid. J.R. Coll. Physicians Edinb. 33: 209 .". In: J.R. Coll. Physicians Edinb. 33: 209 . Taylor & Francis; 2003. Abstract
As part of a larger study on the effects of permethrin-impregnated bednets on the transmission of Wuchereria bancrofti, subjects from 12 villages in the Coastal province of Kenya, south of Mombasa, were investigated. The aims were to update the epidemiological data and elucidate the spatial distribution of W. bancrofti infection. Samples of night blood from all the villagers aged i 1 year were checked for the parasite, and all the adult villagers (aged >/= 15 years) were clinically examined for elephantiasis and, if male, for hydrocele. Overall, 16.0% of the 6531 villagers checked for microfilariae (mff) were found microfilaraemic, although the prevalence of microfilaraemia in each village varied from 8.1%-27.4%. The geometric mean intensity of infection among the microfilaraemic was 322 mff/ml blood. At village level, intensity of the microfilaraemia was positively correlated with prevalence, indicating that transmission has a major influence on the prevalence of microfilaraemia. Clinical examination of 2481 adults revealed that 2.9% had elephantiasis of the leg and that 19.9% of the adult men (10.8%-30.1% of the men investigated in each village) had hydrocele. Although the overall prevalence of microfilaraemia in the study villages had not changed much since earlier studies in the 1970s, both prevalence and intensity varied distinctly between the study villages. Such geographical variation over relatively short distances appears to be a common but seldom demonstrated feature in the epidemiology of bancroftian filariasis, and the focal nature of the geographical distribution should be carefully considered by those mapping the disease.
"A. K. M. Kuria, S. De Coster, G. Muriuki, W. Maseng o, I.O. Kibwage , J. Hoogmartens, and G.M. Laekeman. Antimalarial activity of Ajuga remota Benth (Labiat ae) and Caesalpina volkensii in-vitro confirmation of e thnopharmacological use ." J. Ethnopharmacology . 2001;74:141-148. Abstract

Field trips to herbalists' practices in an area about 200 miles around Nairobi (Kenya) enabled us to make a list of medicinal plant species preferentially used to treat malaria. Ajuga remota and Caesalpinia volkensii were further investigated as being the most frequently used species. Aqueous decoctions, ethanol macerates, and petroleum ether, methanol and water Soxhlet extracts of these plants were further tested for their in vitro antimalarial properties in a chloroquine sensitive (FCA/20GHA) and resistant (W2) strain of Plasmodium falciparum. The activity was assessed by the parasite lactate dehydrogenase (pLDH) assay method. There was a concentration-dependent inhibition by the vegetal extracts of both plants. The IC(50) of the most active A. remota extract (ethanol macerate) was 55 and 57 microg/ml against FCA/20GHA and W2, respectively. For C. volkensii, it was the Soxhlet-water extract which was most active against FCA/20GHA with an IC(50) of 404 microg/ml while the petroleum ether extract exhibited the most activity against W2 with an IC(50) of 250 microg/ml. Further phytochemical work is being done in order to identify the active principles

O PROFOWINOJOHN. "A. M. Achola, N. J. Muthama & J. O. Owino(2006): Influence of Weather on the Insurance Industry in Kenya:.". In: African J. of Sci. & Technol. Vol. 7, No.,pp 112-120. 1999; 2006. Abstract
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ADAM PROFADAMMOHAMED. "A. M. ADAM, D. O. Orinda: Focal kinesigenic choreoathetosis preceding the development of Steele .". In: Journal of Neurology, Neurosurgery and Psychiatry. 49: 957- 959, 1986. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1986. Abstract

One hundred normal lateral skull radiographs were studied and those of ten patients with basilar impression attending Kenyatta Hospital, Nairobi. The mean shortest distance of the odontoid tip to McGregor's basal line was 1.2 +/- 2.28 mm below the basal line (range 6 mm below to 3 mm above basal line), in normals and 9 +/- 2.7 mm (6-14 mm) above basal line in patients. The mean basal angle was 113 degrees +/- 7 degrees (102 degrees-133 degrees) in normals and 122 degrees +/- 6 degrees (113 degrees-125 degrees) in patients. The mean nasion-basion-opisthion angle was 162 degrees +/- 4 degrees (154 degrees-169 degrees) in normals and 178 degrees +/- 5 degrees (173 degrees-185 degrees) in patients. The mean total length of clivus was 48 +/- 3.7 mm (43-56 mm) in normals and 44 +/- 6.6 (36-48 mm) in patients group. The mean median diameter of the foramen magnum was 39 +/- 5 mm (30-48 mm), atlas 21 +/- 3 mm (18-25 mm) axis 18 +/- 3 mm (14-23 mm), third cervical vertebra 16 +/- 2 mm (13-22 mm) in normals and in patients: 39 +/- 4 mm (36-45 mm), atlas 23 +/- 6 (15-30 mm) axis 19 +/- 4 mm (16-25 mm), third cervical vertebra 16 +/- 3 (14-20). There was a significant difference in the position of the odontoid tip and the nasion-basion-opisthion angle between the normal and patient groups. All the other parameters measured in this work did not differ significantly between the two groups.

ADAM PROFADAMMOHAMED. "A. M. ADAM, H. J. Rogers, S. A. Amiel, and R. D. Rubens: The effect of acetylator phenotype On the dispostion of aminoglutethimide . British Journal of Clinical Pharmacology 18:495-505, 1984.". In: Br J Clin Pharmacol. 1984 Oct;18(4):495-505. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1984. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
ADAM PROFADAMMOHAMED. "A. M. ADAM, I. D. Bradbrook, H. J. Rogers: The simultaneous assay of aminoglutethimide and Its acetyl metabolite by high performance liquid chromatography. Journal of Cancer Chemotherapy and Pharmacology . 15: 176-178, 1985.". In: Journal of Cancer Chemotherapy and Pharmacology . 15: 176-178, 1985. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1985. Abstract
A simple rapid high-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and its acetylated metabolite acetylamidoglutethimide in plasma, saliva, and urine is described. This assay is suitable for pharmacokinetic studies in normal subjects and patients receiving other medication in addition to aminoglutethimide
ADAM PROFADAMMOHAMED. "A. M. ADAM, J Nganga and C Muthaura: The profile of N-acetylator status in healthy African volunteers. E.A.M. J. 58: 401-404, 1981.". In: E.A.M. J. 58: 401-404, 1981. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1981. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
ADAM PROFADAMMOHAMED. "A. M. ADAM, Neurological manifestations of Acquired Immunodeficiency Syndrome in a Large teaching hospital in Africa. Advances in Neurology. J. S. Chopra et al editors, Amsterdam Elsevier science publishers, 1999.". In: J. S. Chopra et al editors, Amsterdam Elsevier science publishers, 1999. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1999. Abstract
The prevalence of antibodies against Leishmania donovani in selected domestic and wild animal species in 2 villages in Sudan with active L. donovani transmission in humans was investigated. Screening of domestic animals (donkeys, cows, sheep, goats, camels and dogs) with the direct agglutination test (DAT) detected reaction rates above the cut-off titres in donkeys (68.7%), cows (21.4%) and goats (8.5%), and which were also found in wild rats (5.5%). Sera of sheep, camels and dogs had a weak agglutination reaction below the cut-off titre. Testing of the same sera by enzyme-linked immunosorbent assay (ELISA), against a lysate of L. donovani promastigotes, showed reaction rates above the cut-off optical density in cows (47.6%), goats (13.6%), and in rats (4.1%). No Leishmania parasite was isolated from spleen, liver, bone-marrow or spleen of Nile rats.
ADAM PROFADAMMOHAMED. "A. M. ADAM, P. F. Atkinson, S. M.Hall, R. A. C. Hughes, and W. A. Taylor: Chronic Experimental allergic neuritis in Lewis rats. Neuropathology and Applied Neurobiology. 15: 249-264, 1989.". In: Neuropathol Appl Neurobiol. 1989 May-Jun;15(3):249-64. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1989. Abstract
An experimental chronic relapsing demyelinating neuropathy was produced by immunizing adult Lewis rats with bovine myelin in low (2.5 mg) and high (5 mg) doses, with and without Mycobacterium tuberculosis in the adjuvant. Each regime produced a similar disease course: acute severe hind limb weakness was followed by apparent recovery and then reappearance of mild neurological deficit with occasional spontaneous exacerbations. The partially recovered animals were relatively resistant to reimmunization with myelin. Immunization of four-week-old rats with myelin in complete adjuvant produced disease with a similar course. Subsequent immunization of these juvenile rats with adjuvant alone precipitated exacerbations. In the late stages, the prominent changes in peripheral nerves and nerve roots were axon loss, axonal regeneration and remyelination while inflammatory cell infiltration was confined to occasional foci. Onion bulb formation was extremely common in the dorsal root ganglia and affected in particular the nerve fibres close to the dorsal root ganglion cells. The cells forming the onion bulbs resembled the satellite cells surrounding the axon hillocks. Onion bulb formation also occurred in the portion of the ventral roots adjacent to the dorsal root ganglion but was rare elsewhere. Immunocytochemistry revealed only occasional lymphocyte infiltration but there was increased Class I and Class II MHC antigen expression throughout the peripheral nervous system. The results are relevant to the interpretation of biopsies from patients with chronic demyelinating neuropathy of possible inflammatory or autoimmune origin.
ADAM PROFADAMMOHAMED. "A. M. ADAM, Progressive multi-system degeneration : Report of five cases. Health Line 1: 82 .". In: Report of five cases. Health Line 1: 82 . Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1997. Abstract

Increasing numbers of HIV-infected adults in Africa need hospital care. It remains unclear what impact this has on health care services or on how hospitals respond. The aim of this study was to describe the effects of a rising case load of adult HIV-related disease by comparing results from a prospective cross-sectional study of acute adult medical admissions to a government hospital in Nairobi conducted in 1992 with results from a previous study done in 1988 and 1989 in the same hospital, using the same study design and protocol. Data on age, gender, number admitted, length of stay, HIV status, clinical AIDS, final diagnosis, case mix, and outcome were compared. In 1992, 374 consecutive patients were admitted in 15 24-hour periods (24.9 patients/period) compared with the 1988 to 1989 study, which enrolled 506 patients in 22 24-hour periods (23.0 patients/period). Patients' age, gender, and length of hospital stay were similar in both studies. In 1992, 39% of patients were HIV-positive compared with 19% in 1988 to 1989 (p < 10(-6)); whereas seropositive admissions rose 123% between the two periods (p < .0001), HIV-negative admissions declined 18% (p < .05). Clinical surveillance for AIDS consistently identified <40% of HIV-positive patients. Irrespective of HIV status, tuberculosis and pneumococcal pneumonia were the leading diagnoses in both surveys. No change was found in the diagnoses recorded for HIV-positive patients, but in HIV-negative patients, reductions were significant in the case mix (p < .00001) and range of diagnoses (p < .001) seen in 1992. Outcome remained unchanged for HIV-positive patients with approximately 35% mortality in both surveys. Outcome significantly worsened, in relative and absolute terms, for HIV-negative patients: in 1992, mortality was 23%, compared with 13.9% in 1988 to 1989 (p < .005), with 3.5 deaths per 24-hour period in 1992 compared with 2.6 deaths per 24-hour period in 1988 to 1989 (p < .05, one-tailed). These data suggest that increasing selection for admission is taking place as demand for care increases because of HIV/AIDS. This process appears to favor HIV-positive patients at the expense of HIV-negative patients who seem to be crowded out and, once admitted, experience higher mortality rates. The true social costs of the HIV epidemic are underestimated by not including the effects on HIV-negative people. PIP: The impact of the escalating demand for HIV/AIDS-related care on hospital services in Nairobi, Kenya, was investigated in two prospective cross-sectional studies conducted at Kenyatta National Hospital. Data on age, gender, number of admissions, length of stay, HIV status, clinical AIDS, final diagnosis, case mix, and outcome were compared in a 1988-89 study that enrolled 506 consecutive patients in a total of 22 24-hour periods and in a 1992 study of 374 patients admitted in 15 24-hour periods. 18.7% of hospital patients in 1988-89 were HIV-positive compared with 38.5% in 1992, with a concomitant decline of 18% in the number of HIV-negative admissions. Clinical surveillance for AIDS consistently identified less than 40% of HIV-positive patients. Tuberculosis and pneumococcal pneumonia were the leading diagnoses in both surveys among HIV-positive and HIV-negative patients. Diagnoses recorded for HIV-positive patients did not change over time; however, among HIV-negative patients, there was a significant narrowing in the range of diagnoses seen. Mortality among HIV-positive patients remained constant at 35% in both surveys. Among HIV-negative patients, mortality increased from 13.9% in 1988-89 to 23% in 1992 (2.6 and 3.5 deaths per 24-hour period, respectively). These findings suggest that increasing demand for hospital care by HIV-positive patients has been accompanied by deteriorating conditions for HIV-negative patients, especially an admissions selection process that favors HIV/AIDS patients. Recommended to address the worsening crisis in health care delivery are general guidelines on admission criteria that neither crowd out HIV-negative patients nor discriminate against those with HIV/AIDS.

ADAM PROFADAMMOHAMED. "A. M. ADAM, R. C. Hughes, J. Payan, I. McColl: Peripheral neuropathy and hyperthamia Lancet I : 1270-1271, 1987.". In: Lancet I : 1270-1271, 1987. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1987. Abstract
Over a period of five years, November, 1983 to October, 1988 six cases of definite multiple sclerosis were identified at Kenyatta National Hospital. Four were females and two were males. Age of onset of disease ranged from 12 years to 30 years. Their mode of presentation, clinical features and prognosis is the same as that of multiple sclerosis seen at higher latitudes. The consequences of misdiagnosis to the patient is discussed. A theory is put forward to explain the increased numbers of MS seen recently as compared to the past decades.
ADAM PROFADAMMOHAMED. "A. M. ADAM, S. M. Bhatt. and L. S. Otieno: Behcet.". In: East Afr Med J. 1987 Aug;64(8):558-60. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1987. Abstract
Over a period of five years, November, 1983 to October, 1988 six cases of definite multiple sclerosis were identified at Kenyatta National Hospital. Four were females and two were males. Age of onset of disease ranged from 12 years to 30 years. Their mode of presentation, clinical features and prognosis is the same as that of multiple sclerosis seen at higher latitudes. The consequences of misdiagnosis to the patient is discussed. A theory is put forward to explain the increased numbers of MS seen recently as compared to the past decades.
ADAM PROFADAMMOHAMED. "A. M. ADAM, Subacute demyelinating polyneuropathy in twelve Human Immunodeficiency Virus seropositive patients in Nairobi, Kenya. African Journal of Neurosciences. 1: 92-92, 1993.". In: African Journal of Neurosciences. 1: 92-92, 1993. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1993. Abstract

Increasing numbers of HIV-infected adults in Africa need hospital care. It remains unclear what impact this has on health care services or on how hospitals respond. The aim of this study was to describe the effects of a rising case load of adult HIV-related disease by comparing results from a prospective cross-sectional study of acute adult medical admissions to a government hospital in Nairobi conducted in 1992 with results from a previous study done in 1988 and 1989 in the same hospital, using the same study design and protocol. Data on age, gender, number admitted, length of stay, HIV status, clinical AIDS, final diagnosis, case mix, and outcome were compared. In 1992, 374 consecutive patients were admitted in 15 24-hour periods (24.9 patients/period) compared with the 1988 to 1989 study, which enrolled 506 patients in 22 24-hour periods (23.0 patients/period). Patients' age, gender, and length of hospital stay were similar in both studies. In 1992, 39% of patients were HIV-positive compared with 19% in 1988 to 1989 (p < 10(-6)); whereas seropositive admissions rose 123% between the two periods (p < .0001), HIV-negative admissions declined 18% (p < .05). Clinical surveillance for AIDS consistently identified <40% of HIV-positive patients. Irrespective of HIV status, tuberculosis and pneumococcal pneumonia were the leading diagnoses in both surveys. No change was found in the diagnoses recorded for HIV-positive patients, but in HIV-negative patients, reductions were significant in the case mix (p < .00001) and range of diagnoses (p < .001) seen in 1992. Outcome remained unchanged for HIV-positive patients with approximately 35% mortality in both surveys. Outcome significantly worsened, in relative and absolute terms, for HIV-negative patients: in 1992, mortality was 23%, compared with 13.9% in 1988 to 1989 (p < .005), with 3.5 deaths per 24-hour period in 1992 compared with 2.6 deaths per 24-hour period in 1988 to 1989 (p < .05, one-tailed). These data suggest that increasing selection for admission is taking place as demand for care increases because of HIV/AIDS. This process appears to favor HIV-positive patients at the expense of HIV-negative patients who seem to be crowded out and, once admitted, experience higher mortality rates. The true social costs of the HIV epidemic are underestimated by not including the effects on HIV-negative people. PIP: The impact of the escalating demand for HIV/AIDS-related care on hospital services in Nairobi, Kenya, was investigated in two prospective cross-sectional studies conducted at Kenyatta National Hospital. Data on age, gender, number of admissions, length of stay, HIV status, clinical AIDS, final diagnosis, case mix, and outcome were compared in a 1988-89 study that enrolled 506 consecutive patients in a total of 22 24-hour periods and in a 1992 study of 374 patients admitted in 15 24-hour periods. 18.7% of hospital patients in 1988-89 were HIV-positive compared with 38.5% in 1992, with a concomitant decline of 18% in the number of HIV-negative admissions. Clinical surveillance for AIDS consistently identified less than 40% of HIV-positive patients. Tuberculosis and pneumococcal pneumonia were the leading diagnoses in both surveys among HIV-positive and HIV-negative patients. Diagnoses recorded for HIV-positive patients did not change over time; however, among HIV-negative patients, there was a significant narrowing in the range of diagnoses seen. Mortality among HIV-positive patients remained constant at 35% in both surveys. Among HIV-negative patients, mortality increased from 13.9% in 1988-89 to 23% in 1992 (2.6 and 3.5 deaths per 24-hour period, respectively). These findings suggest that increasing demand for hospital care by HIV-positive patients has been accompanied by deteriorating conditions for HIV-negative patients, especially an admissions selection process that favors HIV/AIDS patients. Recommended to address the worsening crisis in health care delivery are general guidelines on admission criteria that neither crowd out HIV-negative patients nor discriminate against those with HIV/AIDS.

ADAM PROFADAMMOHAMED. "A. M. ADAM. And H. J. Rogers: Gas-liquid chromatographic assay of aminoglutethimide And high-performance liquid chromatographic assay of its acetyl metabolite in biological Fluids. Cancer Chemother Pharmacol. 1985;15(2):176-8.". In: Cancer Chemother Pharmacol. 1985;15(2):176-8. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1985. Abstract
A simple rapid high-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and its acetylated metabolite acetylamidoglutethimide in plasma, saliva, and urine is described. This assay is suitable for pharmacokinetic studies in normal subjects and patients receiving other medication in addition to aminoglutethimide
ADAM PROFADAMMOHAMED. "A. M. ADAM. Co-author in Multi Center trial of azathioprine in Multiple sclerosis. Lancet. I: 179-183, 1988.". In: Lancet. I: 179-183, 1988. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1988. Abstract
Over a period of five years, November, 1983 to October, 1988 six cases of definite multiple sclerosis were identified at Kenyatta National Hospital. Four were females and two were males. Age of onset of disease ranged from 12 years to 30 years. Their mode of presentation, clinical features and prognosis is the same as that of multiple sclerosis seen at higher latitudes. The consequences of misdiagnosis to the patient is discussed. A theory is put forward to explain the increased numbers of MS seen recently as compared to the past decades.
ADAM PROFADAMMOHAMED. "A. M. ADAM. Multiple sclerosis and epidemic in Kenya. 12: East Afr Med J. 1989 Aug;66(8):503-6.". In: East Afr Med J. 1989 Aug;66(8):503-6. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1989. Abstract
Over a period of five years, November, 1983 to October, 1988 six cases of definite multiple sclerosis were identified at Kenyatta National Hospital. Four were females and two were males. Age of onset of disease ranged from 12 years to 30 years. Their mode of presentation, clinical features and prognosis is the same as that of multiple sclerosis seen at higher latitudes. The consequences of misdiagnosis to the patient is discussed. A theory is put forward to explain the increased numbers of MS seen recently as compared to the past decades.
ADAM PROFADAMMOHAMED. "A. M. ADAM: Skull radiographic measurements of normals and patients with basilar impression Use of Landzert.". In: Surgical and Radiologic Anatomy. Vol. 9 issue 3, 1987. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1987. Abstract

One hundred normal lateral skull radiographs were studied and those of ten patients with basilar impression attending Kenyatta Hospital, Nairobi. The mean shortest distance of the odontoid tip to McGregor's basal line was 1.2 +/- 2.28 mm below the basal line (range 6 mm below to 3 mm above basal line), in normals and 9 +/- 2.7 mm (6-14 mm) above basal line in patients. The mean basal angle was 113 degrees +/- 7 degrees (102 degrees-133 degrees) in normals and 122 degrees +/- 6 degrees (113 degrees-125 degrees) in patients. The mean nasion-basion-opisthion angle was 162 degrees +/- 4 degrees (154 degrees-169 degrees) in normals and 178 degrees +/- 5 degrees (173 degrees-185 degrees) in patients. The mean total length of clivus was 48 +/- 3.7 mm (43-56 mm) in normals and 44 +/- 6.6 (36-48 mm) in patients group. The mean median diameter of the foramen magnum was 39 +/- 5 mm (30-48 mm), atlas 21 +/- 3 mm (18-25 mm) axis 18 +/- 3 mm (14-23 mm), third cervical vertebra 16 +/- 2 mm (13-22 mm) in normals and in patients: 39 +/- 4 mm (36-45 mm), atlas 23 +/- 6 (15-30 mm) axis 19 +/- 4 mm (16-25 mm), third cervical vertebra 16 +/- 3 (14-20). There was a significant difference in the position of the odontoid tip and the nasion-basion-opisthion angle between the normal and patient groups. All the other parameters measured in this work did not differ significantly between the two groups.

PROF. NTIBA MICHENIJ, PROF. KINYAMARIO JENESIOI, PROF. MAVUTI KENNETHM. "A. N. Ngari, J. I. Kinyamario, M. J. Ntiba and K. M. Mavuti, 2008, Factors affecting abundance and distribution of submerged and floating macrophytes in Lake Naivasha, Kenya, African Journal of Ecology, Vol 46 (In Press).". In: African Journal of Ecology, Vol 46 (In Press). ELOQUENT BOOKS NY, Strategic Book Group, Connecticut, USA. ISBN-978-1-60911-081-9.Pages1; 2008. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Macrophytes have been shown to perform important ecological roles in Lake Naivasha. Consequently, various studies regarding the impact of biotic factors on the macrophytes have been advanced but related studies on environmental parameters have lagged behind. In an attempt to address this gap, sampling on floating species and submergents was carried out in eight sampling sites in 2003 to investigate how they were influenced by a set of environmental factors. Soil texture (sandy sediments; P < 0.05, regression coefficient = - 0.749) and wind were the most important environmental parameters influencing the distribution and abundance of floating macrophytes. Combination of soil texture and lake-bed slope explained the most (86.3%) variation encountered in the submergents. Continuous translocation of the floating dominant water hyacinth to the western parts by wind has led to displacement of the submergents from those areas. In view of these findings, the maintenance and preservation of the steep Crescent Lake basin whose substratum is dominated by sand thus hosting most submergents remain important, if the whole functional purpose of the macrophytes is to be sustained.
PROF. NTIBA MICHENIJ, PROF. KINYAMARIO JENESIOI, PROF. MAVUTI KENNETHM. "A. N. Ngari, J. I. Kinyamario, M. J. Ntiba and K. M. Mavuti, 2008, Factors affecting abundance and distribution of submerged and floating macrophytes in Lake Naivasha, Kenya, African Journal of Ecology, Vol 46 (In Press).". In: African Journal of Ecology, Vol 46 (In Press). Vaccine 26:2788- 2795; 2008. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Macrophytes have been shown to perform important ecological roles in Lake Naivasha. Consequently, various studies regarding the impact of biotic factors on the macrophytes have been advanced but related studies on environmental parameters have lagged behind. In an attempt to address this gap, sampling on floating species and submergents was carried out in eight sampling sites in 2003 to investigate how they were influenced by a set of environmental factors. Soil texture (sandy sediments; P < 0.05, regression coefficient = - 0.749) and wind were the most important environmental parameters influencing the distribution and abundance of floating macrophytes. Combination of soil texture and lake-bed slope explained the most (86.3%) variation encountered in the submergents. Continuous translocation of the floating dominant water hyacinth to the western parts by wind has led to displacement of the submergents from those areas. In view of these findings, the maintenance and preservation of the steep Crescent Lake basin whose substratum is dominated by sand thus hosting most submergents remain important, if the whole functional purpose of the macrophytes is to be sustained.
N PROFKANYARIPAULW. "A. OMEGA and P.W.N. KANYARI and others (1997). Suitability of the faecal egg sedimentation (FEST) as a quantitative diagnostic technique for fasciolosis in sheep.". In: 6th Annual Seminar of the DANIDA Funded Ruminant Helminth Research Project. 27th - 31st January. ILRI, Kenya. Korean Society of Crop Science and Springer; 1997. Abstract
Twelve Red Masai and 12 Dorper sheep aged between 6 and 9 months, were acquired from a fluke-free area and sheep of each breed divided into two equal groups of six. Each animal in one group of each breed was experimentally infected with 400 viable metacercariae of Fasciola gigantica. The other groups acted as uninfected controls. Blood samples were taken at weekly intervals for the determination of serum bilirubin, albumin and gamma glutamyl transferase levels. Following the establishment of infection, albumin levels declined in both breeds of infected animals without any significant difference between the two breeds. However, serum bilirubin and gamma glutamyl transferase (GGT) in the infected animals were elevated significantly more in the Dorper than in the Red Masai sheep. Based on these findings, it would appear that Dorper sheep are more susceptible to the infection than Red Masai sheep. Keywords: Dorper, Fasciola gigantica, Red Masai, serum biochemical changes
MARTIN DRKOLLMANNKH. "A. R. Pakar, H. S. Adala, K. H. M. Kollmann The prevalence of dry eye syndrome in blacks aged above forty years East African Journal of Ophthalmology, Vol. 11., No. 1 (2002).". In: East African Journal of Ophthalmology, Vol. 11., No. 1 (2002). I.E.K Internatioanl Conference l; 2002. Abstract
OBJECTIVE: To estimate the prevalence and pattern of conjuctival squamous cell carcinoma (CSCC) in patients with HIV infection. DESIGN: A hospital based cross sectional study. SETTING: Kenyatta National Hospital (KNH) and Kikuyu Eye Unit (KEU) during the period November 2003 and May 2004. SUBJECTS: Four hundred and nine HIV positive patients. RESULTS: Four hundred and nine HIV positive patients aged 25 to 53 years were screened. Male to Female ratio was 1:1. One hundred and three had conjunctival growths. Thirty two had histologically proven conjunctiva squamous cell carcinoma (CSCC). Estimated prevalence of CSCC among HIV positive patients was 7.8%. The average duration of growth of the conjunctival masses was 21.8 months. The average size of the lesions at the time of presentation was 6.6 mm. Twenty two (68.8%) patients had primary CSCC, while ten (31.2%) had recurrent lesions. The pattern of the histopathology results was: fifteen (46.9%) patients had poorly differentiated squamous cell carcinoma; nine (28%) had moderately differentiated squamous cell carcinoma; five patients (15.6%) had CIN; two patients (6.3%) had dysplasia and one patient (3.1%) had a well differentiated squamous cell carcinoma. CONCLUSIONS: Prevalence of CSCC in HIV/AIDS patients was 7.8%. Patients present late with advanced lesions. Recurrence rates from previous surgery are high. The often uncharacteristic complaints and findings on presentation complicate the clinical diagnosis. Active search for early manifestations of CSCC in HIV / AIDS patients, complete surgical excision and close follow up is necessary. Alternative treatment methods and techniques like the topical use of antimetabolites should be explored further.
W. PROFMWANGOMBEAGNES. "A. W. Mwang.". In: Plant Pathology Journal 6(2): 141-146 (2007). J Hum Ecol, 26(3): 163-173 (2009).; 2007. Abstract
Participatory rural appraisal techniques and a survey of 100 households were used to evaluate livestock production, and pastoral development of the Maasai in Mara. It was observed that patterns of land-use have principally changed from nomadic pastoralism to sedentary pastoralism, agropastoralism, and, in some cases, pure cultivation. These trends have adversely affected livestock production and the productive capacity of the Mara ecosystem. Diminishing grazing area occasioned by expanding cropping patterns has negatively impacted on vegetation resources and the biodiversity of the ecosystem. It has also increased the intensity of conflict over diminishing land resources. Because the production system is largely subsistence with a strong livestock base, it is further undermined by, among other factors, animal diseases, water scarcity, land individualisation, poor marketing infrastructure, and livestock/wildlife conflicts. Based on the findings of the present study, development approaches need to emphasize integrated livestock and wildlife utilization, land tenure reforms that embody livestock mobility as a key strategy of optimising the use of transient forage resources, disease control, and development of livestock marketing.
W. PROFMWANGOMBEAGNES. "A. W. Mwang.". In: . Plant Pathology Journal 6(3): 235-241 (2007). J Hum Ecol, 26(3): 163-173 (2009).; 2007. Abstract
Participatory rural appraisal techniques and a survey of 100 households were used to evaluate livestock production, and pastoral development of the Maasai in Mara. It was observed that patterns of land-use have principally changed from nomadic pastoralism to sedentary pastoralism, agropastoralism, and, in some cases, pure cultivation. These trends have adversely affected livestock production and the productive capacity of the Mara ecosystem. Diminishing grazing area occasioned by expanding cropping patterns has negatively impacted on vegetation resources and the biodiversity of the ecosystem. It has also increased the intensity of conflict over diminishing land resources. Because the production system is largely subsistence with a strong livestock base, it is further undermined by, among other factors, animal diseases, water scarcity, land individualisation, poor marketing infrastructure, and livestock/wildlife conflicts. Based on the findings of the present study, development approaches need to emphasize integrated livestock and wildlife utilization, land tenure reforms that embody livestock mobility as a key strategy of optimising the use of transient forage resources, disease control, and development of livestock marketing.
W. PROFMWANGOMBEAGNES. "A. W. Mwang.". In: in . J Hum Ecol, 26(3): 163-173 (2009).; 2002. Abstract
Genetic diversity of 50 Phaeoisariopsis griseola isolates collected from different agro ecological zones in Kenya were studied using group specific primers and amplified fragment length polymorphism (AFLP) markers. Group-specific primers differentiated the isolates into Andean and Mesoamerican groups, corresponding to the two common-bean gene pools. Significant polymorphisms were observed with all the AFLP primer combinations used, reflecting a wide genetic diversity in the P. griseola population. A total of 207 finger prints was generated, of which 178 were polymorphic. Cluster analysis of the polymorphic bands also separated the isolates into the two groups defined by group specific primers. All the isolates examined were grouped into three virulence populations; Andean, Afro-Andean and Mesoamerican, and their genetic diversity measured. On average, greater diversity (91%) was detected within populations than between populations (9%). The genetic distance between Andean and Mesoamerican populations was higher (D = 0.0269) than between Andean and Afro-Andean (D = 0.0095). The wide genetic diversity reported here has significant implications in breeding for resistance -to angular leaf spot and should be taken into consideration when screening and deploying resistant bean genotypes.
W. PROFMWANGOMBEAGNES. "A. W. Mwang.". In: African Crop Science Conference Proceedings vol. 5: 123-128, 2001 (ISSN 1023-070X). J Hum Ecol, 26(3): 163-173 (2009).; 2001. Abstract
Fusarium wilt caused by Fusarium udum Butler, is an economically important disease of pigeonpea (Cajanus cajan (L.) Mill). Information on the mechanisms of resistance to this disease in pigeonpea is limited. To study the role of vascular occlusion in wilt resistance, isolates of F.udum were inoculated onto resistant and susceptible varieties of pigeonpea and observed under light and transmission electron microscopes. The presence of F. udum in wilt susceptible plants was characterized by mycelia and conidia in the xylem vessels, plugging in some vessels, disintegration of xylem parenchyma cells in the infected areas, and the formation of cavities due to heavy colonization in the pith cortex vascular bundle. Resistance to F. udum in the roots and stems of wilt resistant plants was associated with low fungal colonization and high occlusion due to tyloses and gels in the xylem vessels. There were significant differences (P = 0:05) in the number of xylem vessels occluded by tyloses in resistant and susceptible plants with a maximum of 22.5% and 8.0% occlusion, respectively. It is probable that tyloses and gels formed as a result of F. udum interaction in wilt resistant plants are part of a resistance mechanism. Key words: Fusarium wilt,cajanus cajan, resistance, tylose, vascular occlusion
W. PROFMWANGOMBEAGNES. "A. W. Mwang.". In: Proceedings of the International Workshop under European Commission contract N. ERB IC18 CT97 0139: pp 95-104 (1998). J Hum Ecol, 26(3): 163-173 (2009).; 1998. Abstract
Fusarium wilt caused by Fusarium udum Butler, is an economically important disease of pigeonpea (Cajanus cajan (L.) Mill). Information on the mechanisms of resistance to this disease in pigeonpea is limited. To study the role of vascular occlusion in wilt resistance, isolates of F.udum were inoculated onto resistant and susceptible varieties of pigeonpea and observed under light and transmission electron microscopes. The presence of F. udum in wilt susceptible plants was characterized by mycelia and conidia in the xylem vessels, plugging in some vessels, disintegration of xylem parenchyma cells in the infected areas, and the formation of cavities due to heavy colonization in the pith cortex vascular bundle. Resistance to F. udum in the roots and stems of wilt resistant plants was associated with low fungal colonization and high occlusion due to tyloses and gels in the xylem vessels. There were significant differences (P = 0:05) in the number of xylem vessels occluded by tyloses in resistant and susceptible plants with a maximum of 22.5% and 8.0% occlusion, respectively. It is probable that tyloses and gels formed as a result of F. udum interaction in wilt resistant plants are part of a resistance mechanism. Key words: Fusarium wilt,cajanus cajan, resistance, tylose, vascular occlusion
M. DROLUBAYOFLORENCE. "A. W. Mwango.". In: Plant Pathology journal 6 (2): 141-146.2007. Dr. Oliver V. Wasonga; 2007. Abstract
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} This study was conducted in two seasons of2002 at Tigoni, Central Kenya to determine effectiveness of insecticides; neern  extract and mineral oil in managing potato aphids and their associated virus diseases. The treatments were arranged in  randomized complete block design (RCBD) with four replications. In each season, the number of aphids in five randomly  selected plants per treatment was recordced in situ. Virus symptoms (i.ncidence) were scored and expressed as a percentage  to the total plant population per plot. Forty-five days after emergence, 10 plants each from guard rows and inner rows were  randomly selected and serologically assayed for Potato Virus Y (PVY) and Potato Leaf Roll Virus (PLRV) using DAS ELISA test. Results showd that three aphid species Aphis gossypii (Glover), Macrosiphum euphorbiae (Thomas) and Myzus persicae (Sulzer) colonized on the variety with A. gossypii being the most dominant while M. persicae was least.  Higher aphid population coincided with the short rains experienced in one of the seasons. Synthetic insecticides (Bifethrin  and dimethoate) were the most effective among the treatments in reducing aphid infestation while the neem extract and mineral oil (DC- Tron) had no significant (P<0.05) difference. However, mineral-oil treated plots recorded the lowest PVY  incidence while bifenthrin-Ireated plots had the lowest PLRV incidence. It is suggested that a combination of synthetic  insecticides and mineral oil could playa major role in reduction of the aphids and their associated vectors. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
PROF. ADUDA BERNARD O. "A.A. Ogacho, B.O. Aduda and F.W. Nyongesa (Dec. ), Thermal Shock Behaviour of a Kaolinite Refractory Prepared Using a Natural Organic Binder,.". In: Journal of Materials Science, 41(24) 8276 . Physica Status Solidi; 2006. Abstract
This study investigated the effectiveness of three physical-chemical methods namely; pH adjustment, precipitation with alum and the use of polyelectrolytes. In the treatment of diary wastewater from Brookeside milk processing plant. It also investigated the drainability of the sludge produced by each of the three methods. Laboratory tests were carried out in three different batches, one for each of the three methods. In the alum method enough alum was added to the wastewater samples to cause precipitation by sweep floc. In the pH adjustment method, the pH of samples were lowered to the iso-electric point of the casein proteins of approximately pH 4.5 leading to their precipitation as a result of solubility changes. The polyelectrolytes method involved the use of two polyelectrolytes, Sudfloc 3820 and Sudfloc 3860 each of which was used to coagulate the dirty wastewater. For each of the three methods, the samples were taken in one-litre beakers and subjected to Jar tests to determine the optimum dosages. After one hour of settling the supernatants were decanted and subjected to standard Chemical Oxygen Demand (COD) tests, turbidity and pH measurements. The settled sludge was subjected to drainability studies. Results showed the treatment of dairy wastewater by the three physical-chemical methods to be effective. There were COD removals of between 60% and 90% and turbidity reduction of over 90%. The use of the sudfloc polyelectrolytes was found to be the least demanding in terms of effluent quality control as no pH adjustments of either the wastewater or the effluent was required. The use of polyelectolytes produced the least volumes of sludge and also the better drainability and solids concentration. Sudfloc 3820 was found to achieve better results than Sudfloc 3860 in terms of COD reduction and the drainability of sludge produced although both achieved the same drainability studies. This study showed that each of the three physical-chemical methods can be used effectively to remove the white colour of dairy wastewater as well as the bulk of the proteins and fats, hence, enabling the discharge of the effluents into natural waters to be of good assimilative capacity.
M. DRWASIKEADUA. "A.A.M. Wasike, N. R.Ndungu., G.P. Pokhariyal: Global asymptotic behaviour of Aquatic Vegetation in a system with periodic Nutrient supply,.". In: African journal of science ant Technology (AJST) Vol. 7 No.4 (2006), 41-50. Starmat Designers & Allied, Nairobi; 2006. Abstract
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SIMIYU PROFWANDIBBA. "A.B.C. Ocholla-Ayayo and J. Akong'a - Eds. Family change and human development in Kenya Fertility, Mortality and Culture.". In: Gideon S. Were Press, Nairobi. Taylor & Francis; 1985. Abstract
Although early diagnosis and treatment are key factors in the effective control of human African trypanosomiasis (HAT), many cases of the disease delay taking appropriate action, leading to untold suffering. As a better understanding of treatment-seeking behaviour should help in identifying the obstacles to early diagnosis and effective treatment, the treatment pathways followed by 203 former HAT cases in western Kenya and eastern Uganda have recently been explored. About 86% of the HAT cases had utilized more than two different healthcare options before being correctly diagnosed for HAT, with about 70% each using more than three different health facilities. Only about 8% of the cases reported that they had been correctly diagnosed the first time they sought treatment. Just over half (51%) of the HAT cases had been symptomatic for >2 months before being correctly diagnosed for HAT, and such time lags in diagnosis contributed to 72% of the cases receiving their first appropriate treatment only in the late stage of the disease. The likelihood of a correct diagnosis increased with the time the case had been symptomatic. These observations indicate an urgent need to build the diagnostic capacity of the primary healthcare facilities in the study area, so that all HAT cases can be identified and treated in the early stage of the disease.
ONYINO PROFSIMWARICHARD. "A.dynamical model for stage-specific HIV incidences with application to sub-Saharan Africa.". In: Journal of Applied Mathematics and Computation Vol. 146, page. The Icfai University Journal of Architecture, Vol. II No.1, February 2010; 2003.
GICHOHI DRMBUTHIAPAUL. "A.G Thaiyah, P.N Nyaga, J.M Maribei, D Nduati, P.G Mbuthia, T.A Ngatia. 2010. Experimental solanum incanum l. poisoning in goats.Bulletin of Animal Health and Production in Africa 58: 35-43.". In: Bulletin of Animal Health and Production in Africa Vol 58, No 1. Bulletin of Animal Health and Production in Africa; 2010. Abstract
bstract Localization of Newcastle disease viral nucleoprotein and pathological lesions was evaluated in tissues of 55 indigenous ducks (45 experimentally infected and 10 sentinel ones). In addition, ten Newcastle disease infected chickens were used to ensure that the virus inoculum administered to the ducks produced the disease in chickens, the susceptible hosts. Ducks were killed on day 1, 4, 8 and 14 post-infection. Postmortem examination was done with six tissues (liver, spleen, lung, caecal tonsils, kidneys and brain) being collected from each bird. The tissues were preserved in 10% neutral formalin for 24 h. They were then transferred to 70% ethanol for histology and immunohistochemical staining. Airsacculitis, necrotic splenic foci, congested intestines, lymphoid depleted caecal tonsils and focal infiltrations by mononuclear cells were the main pathological lesions in infected ducks. Over 28.9% of the infected ducks had Newcastle disease viral nucleoprotein in macrophage-like large mononuclear cells in the caecal tonsils and kidney tubular epithelium. The viral antigens were located in the cytoplasm and nucleolus of the cells. The other organs had no detectable viral antigens. This study shows that the kidneys and caecal tonsils are the likely predilection sites for the virus in ducks. They thus need to be considered as diagnostic indicators for the viral carriage in ducks
GITAU DRTHAIYAHANDREW. "A.G. Thaiya, S.M. Ndurumo, J.K. Wabacha. Suspected Nitrate/Nitrite poisoning in stall-fed dairy Cattle resulting from consumption of Amaranthus Plants.". In: Faculty of Veterinary Medicine Biennial Scientific Conference, Nairobi, 3rd . Kenya veterinarian; 2005. Abstract
This case report describes an outbreak of acute dermatophilosis in a large scale dairy herd and highlights that the disease in Kenya could occur in outbreak proportions and in clinically severe form as has been reported in other countries in West and central Africa.We believe that this is the 1st documented outbreak of a severe form of bovine cutaneous dermatophilosis in exotic dairy animals in Kenya.
K PROFWABACHAJAMES. "A.G. Thaiya, S.M. Ndurumo, J.K. Wabacha. Suspected Nitrate/Nitrite poisoning in stall-fed dairy Cattle resulting from consumption of Amaranthus Plants.". In: Faculty of Veterinary Medicine Biennial Scientific Conference, Nairobi, 3rd . Bull. Environ. Contam. Toxicol; 2004. Abstract
A longitudinal study was carried out in Kikuyu Division (a peri-urban area in central Kenyan highlands) between January 1999 and December 1999 to estimate the baseline parameters on reproductive performance of the sow, as well as health and productivity of grower and preweaning pigs of smallholder herds. Data were collected on 155 breeding pigs, 795 grower pigs and 801 preweaning piglets in 74, 50 and 40 smallholder herds, respectively, using record cards that were updated during monthly visits. The sow-level medians were: weaning-to-service interval 3 months; interfarrowing interval 6.4 months; number of live-born piglets 9.0; and number of piglets weaned per litter 7.5. The piglet crude morbidity incidence risk was 29%. The cause-specific incidence risks for the important health problems encountered in preweaned piglets were diarrhea (4.3%), pruritus (17.1%), and skin necrosis (4.2%). The estimated crude mortality incidence risk to 8 weeks of age was 18.7%. The cause-specific mortality incidence risks to 8 weeks of age for the important causes of mortality were overlying (9.9%), savaging (2.4%), unviable piglets (2.0%) and unknown (1.9%). Overall, 78.8% of the total live-born piglet mortality occurred during the first week postpartum with 69% of these deaths being caused by overlying. The grower-pig crude morbidity incidence risk was 20% and the cause-specific incidence risks of the important health problems encountered were gut edema (1.3%), pruritus (21.1%), and unknown (2.3%). The crude mortality incidence risk was 3.8% and the important causes were gut edema and unknown causes (cause-specific mortality incidence risks of 1.3 and 1.6%, respectively). The median weight:age ratio and average daily weight gain for the grower pigs were 5.1 kg/month of age and 0.13 kg/day, respectively. For preweaning pigs, the median average daily weight gain was 0.13 g/day.
M. DROLUBAYOFLORENCE. "A.K. Chirchir, J.W.Kimenju, F.M. Olubayo and G.K. Mutua 2008. Abundance and distribution of Plant parasitic Nematodes associated with sugarcane in Western Kenya.". In: Asian Journal of plant pathology 2(1) 48-53. Dr. Oliver V. Wasonga; 2008. Abstract
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} This study was conducted in two seasons of2002 at Tigoni, Central Kenya to determine effectiveness of insecticides; neern  extract and mineral oil in managing potato aphids and their associated virus diseases. The treatments were arranged in  randomized complete block design (RCBD) with four replications. In each season, the number of aphids in five randomly  selected plants per treatment was recordced in situ. Virus symptoms (i.ncidence) were scored and expressed as a percentage  to the total plant population per plot. Forty-five days after emergence, 10 plants each from guard rows and inner rows were  randomly selected and serologically assayed for Potato Virus Y (PVY) and Potato Leaf Roll Virus (PLRV) using DAS ELISA test. Results showd that three aphid species Aphis gossypii (Glover), Macrosiphum euphorbiae (Thomas) and Myzus persicae (Sulzer) colonized on the variety with A. gossypii being the most dominant while M. persicae was least.  Higher aphid population coincided with the short rains experienced in one of the seasons. Synthetic insecticides (Bifethrin  and dimethoate) were the most effective among the treatments in reducing aphid infestation while the neem extract and mineral oil (DC- Tron) had no significant (P<0.05) difference. However, mineral-oil treated plots recorded the lowest PVY  incidence while bifenthrin-Ireated plots had the lowest PLRV incidence. It is suggested that a combination of synthetic  insecticides and mineral oil could playa major role in reduction of the aphids and their associated vectors. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
GITAU DRTHAIYAHANDREW. "A.K. Maina, J.K Muthee, Thaiya, A.G and V.T. Tsuma (1991). An outbreak of progressive cataracts of an undetermined cause in a herd of dairy cows.The Indian Journal of Animal Sciences vol. 61 no. 11.". In: MSc thesis, Faculty of vet. medicine, university of Nairobi. The Indian Journal of Animal Sciences; 1991. Abstract
This report concerns an outbreak that occurred during July/August 1997. Ten pigs from a herd of 181 pigs in a medium-scale, semi-closed piggery in Kiambu District, Kenya, contracted the clinical disease. The main clinical findings in affected pigs included: fever (40.5-41.8 degrees C), prostration, inappetence, dog-sitting posture, abortion, erythema and raised, firm to the touch and easily palpated light pink to dark purple diamond-shaped to square/rectangular spots on the skin around the belly and the back. Based on the pathognomonic skin lesions, a clinical diagnosis of swine erysipelas was made. The diagnosis was confirmed by the isolation of Erysipelothrix rhusiopathiae organisms from the blood and skin biopsies taken from the affected pigs. Response to treatment with a combination of procaine penicillin and dihydrostreptomycin at the dosage rate of 20,000 IU/kg body weight (based on procaine penicillin) for 3 days was good and all the affected pigs recovered fully. The farm was placed under quarantine to prevent spread of the disease
ADAM PROFADAMMOHAMED. "A.M. ADAM. Unusual form of motor neuron disease in Kenya. 10: East Afr Med J. 1992 Feb;69(2):55-7.". In: East Afr Med J. 1992 Feb;69(2):55-7. Gitau, W., Ogallo L. A. and Mutemi, J. N.,; 1992. Abstract
Over the period November 1978 to October 1988, 46 cases of motor neuron disease were seen at Kenyatta National Hospital, Nairobi. One case was seen in private practice. A bimodal age distribution of the disease was identified with a peak in the fourth decade of life and another peak in the sixth decade of life. The disease seen in the fourth decade of life was different as seen in other parts of the world in that the majority of patients tended to present with very rapidly progressive disease despite the primary presentation with limb symptoms and signs. Serum cholinesterase activity in five of these patients and five of the classical motor neuron disease revealed no abnormalities. This unusually rapidly progressive disease in young adults has not been described anywhere. The disease seen in older age groups and especially in patients over fifty years of age was not different from the one seen in other parts of the world.
MUSAKULU DRKEMOLIARTHUR. "A.M. Kemoli. Prevalence of Molar Incisor Hypomineralization in six to eight year-olds in two rural divisions in Kenya. E. Afr Med J 2008; 85 (10): 514 .". In: The Kenya Accountant, Vol. 1:14; Vol.2. E Afr Med J; 2008. Abstract
Objective: To determine the prevalence of Molar Incisor Hypomineralization (MIH) and any associated causes of MIH in children from two rural divisions in Kenya. Design: Prospective cross-section study. Setting: Seventeen primary schools in Matungulu and Kangundo divisions of Machakos district in Kenya. Participants: All 6 to 8 year-olds in the seventeen primary schools. Results: A total of 3,591 children (55.6% males and 44.4% females) were examined for MIH. All the children were from a low socioeconomic community with little access to proper medical/dental health care. The prevalence of MIH was 13.73%, with a female to male ratio of 3:1. Conclusion: The prevalence of MIH is high in the study population and is probably associated with the poor health conditions that the children went through at the most venerable period of between birth and age 3 years.
OKEYO DRMWAIALFAYO. "A.M. Okeyo and R.A. Aman. 2000. Characterization of indigenous Kenyan fat-tailed and fat-rumped sheep breeds: Levels of diversity in blood proteins. In Proc. Biennial Scientific Conference of the Faculty of Veterinary Mediciene, University of Naorobi on A.". In: Biennial Scientific Conference of the Faculty of Veterinary Mediciene, University of Naorobi. Rao, W. O., Ogonji, J. A.. and Aywa, S.; 2000. Abstract
PIP: This research report studies several biochemical and histochemical aspects of cervical carcinoma and explores their use in follow-up of patients undergoing radiotherapy. Material came from 19 patients with invasive cervical carcinoma admitted to Kenyatta National Hospital. A control group consisted of 20 women matched for age who attended clinics at the hospital but were not suffering from any malignant disease; control tissue for histological examination was obtained from 3 women who had undergone hysterectomy for uterine fibroids. Biochemical assays for alkaline and acid phosphatases in patients with cervical carcinoma show an increase in alkaline phosphatase in carcinomatous tissue (35.7 umoles/hr/mg) as opposed to normal tissue (7.2). Acid phosphatase values were only moderately raised. Assays of the same enzymes in blood showed a less marked difference between patients and controls (ranges of 7.5-20.8 and 3-14, respectively). When examined histochemically, increased alkaline phosphatase activity was observed in connective tissue, epithelium of the glands and blood capillaries of tumor tissue. 1 section containing normal tissue bordering carcinomatous tissue demonstrated normal alkaline phosphatase activity in the normal tissue and increased activity in the tumor tissue. In summary, there is increased enzyme activity around the tumor areas, but values for serum levels show an overlap of normal and abnormal cases and are therefore not predictive. Results demonstrate a clear difference in activities of these enzymes in carcinomatous tissue and normal tissue, which may be of value in follow-up care.
MOSES DRKURIAKIMANIARTHUR. "A.N. Guantai, J.W. Mwangi, Gichuru Muriuki and K.A.M. Kuria (1987). Effects of the active constituents of Catha edulis on the neuromuscular junction. Neuropharmacology 26(5), 401 - 405.". In: East Centr. Afr. J. Pharm. Sci. EAMJ; 1987. Abstract
A cross sectional study of 115 patients admitted at the Department of Orthopedics, Kenyatta National Hospital, Nairobi, Kenya was carried out to determine the prevalence and antibiotic susceptibility of Staphylococcus aureus isolated from infected wounds. The prevalence of Staphylococcus aureus was 33.0 %. The drugs tested and their corresponding sensitivity was amoxycillin (13.2 %), co-amoxyclav (39.5 %), oxacillin (55.3 %), erythromycin (44.7 %), gentamicin (60.5 %), ciprofloxacin (62.2 %), minocycline (86.8 %), cefuroxime (57.9 %), and clidamycin (84.2 %). These results show the sensitivity profile of Staphylococcus aureus and can be used to choose suitable drugs in the management of wounds for hospitalized patients.
MOSES DRKURIAKIMANIARTHUR. "A.N. Guantai, J.W. Mwangi, Gichuru Muriuki and K.A.M. Kuria (1987). Effects of the active constituents of Catha edulis on the neuromuscular junction. Neuropharmacology 26(5), 401 - 405.". In: East Centr. Afr. J. Pharm. Sci. EAMJ; 1987. Abstract
A cross sectional study of 115 patients admitted at the Department of Orthopedics, Kenyatta National Hospital, Nairobi, Kenya was carried out to determine the prevalence and antibiotic susceptibility of Staphylococcus aureus isolated from infected wounds. The prevalence of Staphylococcus aureus was 33.0 %. The drugs tested and their corresponding sensitivity was amoxycillin (13.2 %), co-amoxyclav (39.5 %), oxacillin (55.3 %), erythromycin (44.7 %), gentamicin (60.5 %), ciprofloxacin (62.2 %), minocycline (86.8 %), cefuroxime (57.9 %), and clidamycin (84.2 %). These results show the sensitivity profile of Staphylococcus aureus and can be used to choose suitable drugs in the management of wounds for hospitalized patients.
KARURI PROFGATHUMBIPETER. "A.N. Maina, T.A. Ngatia, D.I. Karioki, P.K. Gathumbi, T.A. Abuom, P.N. Gitonga and V.T. Chemis (2006). Ventricular encephalitis associated with Leukemic lymphosarcoma in a bovine calf. Bull. Anim Hlth. Prod. Afr. 54: 100-109.". In: Bull. Anim Hlth. Prod. Afr. 54: 100-109. Bull. Anim Hlth. Prod. Afr. 54: 100-109; 2006. Abstract
Aim of the study: This study was conducted to document herbal medicines used in the treatment of Malaria as well as the existing knowledge,attitudes and practices related to malaria recognition, control and treatment in South Coast, Kenya. Methods: Data was collected using semistructured questionnaires and interviews. A focused group discussion held with the community members, one in each of the study villages supplemented the interview and questionnaire survey. Results: The respondents were found to have a good understanding of malaria and could distinguish it from other fever types. They were also aware that malaria was spread by mosquitoes. Malaria prevalence was high, and affected individuals an average of four times a year. Community members avoided. Mosquito bites by using mosquitonets, clearing bushes around their homesteads and burning plant parts. To generate smoke. They prevented and treated malaria by taking decoctions or concoctions of traditional herbal remedies. Forty plant species in thirty-five genera distributed in twenty-four families were used as antimalarials in the study area. Five plant species, namely; Heeria insignis Del. (Anacardiaceae), Rottboelia exaltata L.F (Gramineae), Pentanisia ouranogyne S. Moore (Rubiaceae), Agathisanthenum globosum (A. Rich) Hiern (Rubiaceae), and Grewia trichocarpa Hochst ex A. Rich (Tiliaceae) are documented for the first time in South Coast, Kenya, for the treatment of malaria. Conclusions: The plants documented in the current study are a potential source for new bioactive compounds of therapeutic value in malaria treatment. The results provide data for further pharmacological and toxicological studies and development of commercial antimalarial phytotherapy products.
"A.O. MAIMA, G.N. THOITHI, S.N. NDWIGAH, F.N. KAMAUI ,O. KIBWAGE. Phytosterols from the stem bark of Combretum fragrans F. Hoffm.". 2008. Abstract

Two sterols, P-sitosterol and stigmasterol, were isolated from the stem bark of
Combretum fragrans,__The identity of these .compounds was established by-spectral
analysis.

M PROFSHIUNDUPAUL. "A.P. Wade*, P.M. Shiundu. and P.D. Wentzell: .". In: Federation of Analytical Chemistry and Spectroscopy Society (FACSS) XVII, Cleveland, October 1990. AWC and FES; 1988. Abstract
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MACHARIA PROFNGANGAPETER. "Aasrum E, Ng'ang'a PM, Dahm S, Ogaard B. Tensile bond strength of orthodontic brackets bonded with a fluoride-releasing light-curing adhesive. An in vitro comparative study.". In: Am J Orthod Dentofacial Orthop. 1993 Jul;104(1):48-50. Elsevier; 1993. Abstract
Department of Orthodontics, Faculty of Dentistry, University of Nairobi, Kenya. A light-curing, fluoride-releasing adhesive (VP 862, Vivadent, Liechtenstein) for bonding of brackets has been produced for inhibition of white spot lesions during orthodontic treatment. The tensile bond strength after 24 hours and 6 months was investigated and compared with two other light-curing adhesives (Transbond, 3M Corp., Monrovia, Calif., and Heliosit-Orthodontic, Vivadent, Liechtenstein) and two chemical-curing adhesives (Concise, 3M, Monrovia Calif., and Saga Bond, Saga Orthodontics, Kongsvinger, Norway). All adhesives produced adequate strength to be recommended for clinical use. The light-curing adhesives produced slightly lower bond strengths after 24 hours and 6 months, except Transbond, which showed an increase in bond strength in this period approaching the two chemical adhesives.
Mwonga PV, Makau NW, Amolo GO, Lutta S, Okoth MDO, Musembi RJ, Maghanga CM, R. Gateru, Mwabora J. Ab-initio Studies of Point Defects in : A Density Functional Approach. United Kenya Club, Nairobi, 28-29th November 2013; 2013. Abstract

Titanium dioxide has been intensively studied as a wide band gap transition metal oxide due to its n-type semi-conducting property which makes it to have many applications in industry. Some of the observed conductivity arises from its intrinsic point defects. The structural properties and electronic band structures of TiO2 (rutile and anatase) phases, have been investigated using ab-initio methods. The structural properties were obtained using generalized gradient approximation (GGA) employing pseudopotentials and plane wave basis sets. For the two phases of TiO2, the calculated equilibrium lattice constants, bulk moduli and bond lengths were found to be in good agreement with other recent theoretical calculations and also with experimental data. After introduction of various defects to the perfect super cell, the Ti-O bond lengths were altered greatly. The apical bond lengths changed from a constant 1.959 Å to a range of values (1.718 - 1.861) Å, and the equatorial bond lengths changed from a constant 2.006 Å to a range of values (2.072 - 2.231 ) Å for rutile TiO2. The apical bond lengths changed from a constant 1.956 Å to a range of values (1.782 - 1.830) Å, and the equatorial bond lengths changed from a constant 2.050 Å to a range of values (2.112 - 2.214) Å, for anatase TiO2. Also altered were Ti-O-Ti angles, from the two constants (99.93, 131.04)° to a range of values (88.86 - 95.69 and 132.01 - 143.49)° for rutile TiO2. For anatase TiO2, Ti- O-Ti angles changed from the two constants (103.81, 152.39)° to a range of values (93.59 - 149.91 and 156.74 - 176.05)°. Electronic properties were investigated too. Perfect rutile and anatase super cells gave band gaps of 2.24 eV and 2.44 eV, respectively, underground-state conditions. Valence bandwidths (VB) and conduction bandwidths (CB) were also obtained for both phases. VB of 5.6 eV and CB of 1.654 eV were observed for rutile TiO2, while VB of 4.76 eV and CB of 2.35 eV were observed for anatase TiO2; all in good agreement with experimental values. This study also investigated the defect formation enthalpies of Frenkel and Schottky defects in both rutile and anatase phases of TiO2. This study also considered point defect stability in rutile and anatase phases of TiO2. The formation energies for oxygen and titanium atoms, defects were found to be in agreement with the experimental values, especially the case of rutile oxygen atom vacancy. Both Frenkel and Schottky defects were found to induce new energy states in titanium dioxide. Normally band gaps are reduced in defective TiO2 crystals, and in this study, reduced energy band gaps were reported for all the defective super cells. In rutile, the metal oxide gaps were found to almost vanish due to the presence of oxygen atom vacancy, oxygen atom Frenkel and titanium Frenkel defects. These gave direct energy band gaps: 0.35 eV, 0.207 eV and 0.327 eV, respectively. Defects in anatase phase showed a similar trend, with the least energy band gap being reported for the case titanium interstitial (0.041 eV, which is indirect). With such infinitesimal gaps, these otherwise insulating oxides can with ease become conducting metal oxides, by either increasing the temperatures or pressure since these calculations were done at 0 K and 0 pressure. It can thus be said that intrinsic point defects in titanium dioxide do contribute to the improvement of the electrical conductivity of this oxide.

Kivai JM, Guantai AN, Mwanda WO, Maitho TE. "Abandonment of treatment and loss to follow up: a potential cause of treatment failure in patients with AIDS-related Kaposi’s sarcoma." African Journal of Pharmacology and Therapeutics. 2015;4(4):156-160. Abstract2015_-_abandonment_of_treatment_and_ltfu_aids_karposis.pdf

Background: Management of patients with cancer is complex, multi-disciplinary, longitudinal and costly. Abandonment of treatment by patients and loss to follow up is a common scenario, especially in resource poor countries and severely compromises health outcomes.

Objective: To assess the commitment to drug treatment protocol of patients with Acquired Immunodeficiency Syndrome (AIDS)-Related Kaposi’s Sarcoma at Kenyatta National Hospital, Kenya, over a 10 week period .

Methods: The study design was prospective, observational, cross-sectional period prevalence study on patients infected with human immunodeficiency virus (HIV) with Kaposi’s sarcoma. Patients with histological diagnosis of Kaposi’s sarcoma were sequentially enrolled into the study as they attended either the Haematology or Radiotherapy clinic or during their admission in the wards. The choice of the treatment protocol was left at the discretion of the attending physician. A pretested data collection form was used to collect demographic and clinical information about the patients, including treatments prescribed and completion of follow up.

Results: A total of 74 patients were enrolled into the study, 42 (56.8%) males and 32 (43.2%) females. The age ranged between 13 years to 55 years. Their treatment protocols included: Vincristine only, Vincristine plus Bleomycin, Vincristine plus Bleomycin plus Doxorubicin, Radiotherapy plus Vincristine and Radiotherapy only. Few of the patients were not assigned any antitumor treatment. Antiemetic and other conventional medicines were also prescribed when necessary. Fifty four (73%) of the patients abandoned treatment, five (6.8%) died, 15(20.3%) continued to attend clinic over the 10 week period. There was no significant association between sex and outcome (p=0.661).

Discussion: The results of this study demonstrate that abandonment of treatment is a major problem among patients on treatment for cancer in Kenyatta National Hospital in Kenya. Abandonment of treatment heavily contributes to poor clinical outcome hence complicating the burden of cancer in the country. It is therefore important to develop and establish follow-up systems to improve adherence to treatment for the cancer patients at Kenyatta National Hospital.

Key words: Abandonment of treatment, Loss to follow up, AIDS-Related Kaposi’s Sarcoma

WAMBUI PROFKOGIMAKAU-. "Abate, A., Kogi-Makau, W. and Muroki, N.M. Hygiene and Health Seeking Behaviour of Households as Predictors of Nutritional Insecurity among Preschool Children in Urban Slums in Ethiopia- The Case of Addis-Ababa. South African Journal of Clinical Nutrition.". In: Paper presented at the Inaugural National Nutrition Congress. 21st-23rd February 2005. AIDS 24(6):891-7; 1999. Abstract
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, London, UK. Previous attempts to determine the interactions between filariasis transmission intensity, infection and chronic disease have been limited by a lack of a theoretical framework that allows the explicit examination of mechanisms that may link these variables at the community level. Here, we show how deterministic mathematical models, in conjunction with analyses of standardized field data from communities with varying parasite transmission intensities, can provide a particularly powerful framework for investigating this topic. These models were based on adult worm population dynamics, worm initiated chronic disease and two major forms of acquired immunity (larval- versus adult-worm generated) explicitly linked to community transmission intensity as measured by the Annual Transmission Potential (ATP). They were then fitted to data from low, moderate and moderately high transmission communities from East Africa to determine the mechanistic relationships between transmission, infection and observed filarial morbidity. The results indicate a profound effect of transmission intensity on patent infection and chronic disease, and on the generation and impact of immunity on these variables. For infection, the analysis indicates that in areas of higher parasite transmission, community-specific microfilarial rates may increase proportionately with transmission intensity until moderated by the generation of herd immunity. This supports recent suggestions that acquired immunity in filariasis is transmission driven and may be significant only in areas of high transmission. In East Africa, this transmission threshold is likely to be higher than an ATP of at least 100. A new finding from the analysis of the disease data is that per capita worm pathogenicity could increase with transmission intensity such that the prevalences of both hydrocele and lymphoedema, even without immunopathological involvement, may increase disproportionately with transmission intensity. For lymphoedema, this rise may be further accelerated with the onset of immunopathology. An intriguing finding is that there may be at least two types of immunity operating in filariasis: one implicated in anti-infection immunity and generated by past experience of adult worms, the other involved in immune-mediated pathology and based on cumulative experience of infective larvae. If confirmed, these findings have important implications for the new global initiative to achieve control of this disease.
MOHAMED PBADAMANA. "Abate, A., M.M. Wanyoike, M.S. Badamana and A.N. Abate (1989). Towards improving animal production in the Rangelands. In: proceedings of the 16th Grassland congress, Niece, France. Vol. 2pp. 1613 .". In: In: proceedings of the 16th Grassland congress, Niece, France. Vol. 2pp. 1613 . Journal of BiochemiPhysics; 1989.
W. DRWAKHUNGUJACOB. "Abate. A, J.W. Wakhungu, and A.N. Said (1995). Cattle, Goats, Sheep and Camel Production on Range. The Kenya Experience. Bull. Animal Hlth, Prod. Afri. 43: 145-158.". In: Paper presented for APSK symposium 7th-8th March, 2001 Egerton University Njoro, Kenya. Institute of African Studies, University of Nairobi; 1995.
Nansen P, Kyvsgaard NC, Thamsborg SM, Munyua WK, Munyua WK, Gathuma JM, Bogh HO. "An abattoir survey of gastrointestinal nematode infections in cattle in the central highlands of Kenya.". 1997. AbstractWebsite

The gastrointestinal tracts of 672 crossbred cattle were obtained from various abattoirs in Kiambu District, Kenya from August 1992 to July 1993, and examined for the presence of gastrointestinal nematodes. Eight nematode species were found in 583 (86.8%) of the animals. The nematodes were, in order of prevalence: Haemonchus placei (67.0%), Cooperia pectinata (53.0%), Cooperia punctata (41.7%), Oesophagostomum radiatum (38.4%), Trichostrongylus axei (24.3%), Nematodirus helvetianus (19.6%), Trichuris globulosa (9.7%) and Strongyloides papillosus (3.6%). The intensity of the nematode infection was moderate; the mean burden being less than 7000 worms. H. placei accounted, on average, for 52.3% of the total burden. The total burden was least during the dry seasons and increased gradually during the rainy seasons. Adult H. placei persisted in the host throughout the year and there was no indication of hypobiosis. The heaviest gastrointestinal worm burdens were detected in 1.5- to 3-year-old animals. These findings are discussed with regard to their relevance for strategic control of gastrointestinal nematodes in cattle.

"An abattoir survey of gastrointestinal nematode infections in cattle in the central highlands of Kenya.". 1998. Abstract

The gastrointestinal tracts of 672 crossbred cattle were obtained from various abattoirs in Kiambu District, Kenya from August 1992 to July 1993, and examined for the presence of gastrointestinal nematodes. Eight nematode species were found in 583 (86.8%) of the animals. The nematodes were, in order of prevalence: Haemonchus placei (67.0%), Cooperia pectinata (53.0%), Cooperia punctata (41.7%), Oesophagostomum radiatum (38.4%), Trichostrongylus axei (24.3%), Nematodirus helvetianus (19.6%), Trichuris globulosa (9.7%) and Strongyloides papillosus (3.6%). The intensity of the nematode infection was moderate; the mean burden being less than 7000 worms. H. placei accounted, on average, for 52.3% of the total burden. The total burden was least during the dry seasons and increased gradually during the rainy seasons. Adult H. placei persisted in the host throughout the year and there was no indication of hypobiosis. The heaviest gastrointestinal worm burdens were detected in 1.5- to 3-year-old animals. These findings are discussed with regard to their relevance for strategic control of gastrointestinal nematodes in cattle.

T.M. 26. W, et al. "Abattoirs and echinococcosis and Nairobi dogs." Transactions of the Royal Society Tropical Medicine and Hygiene. 1994;88:166-167.
M. PROFKABIRAWANJIKU. "The ABC of Gender Analysis, Ed. Kabira W. Masheti M. FAWE/UNESCO Publication, Nairobi.". In: East African Medical Journal 68(9): 714-9. AIDS 24(6):891-7; 1995. Abstract
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, London, UK. Previous attempts to determine the interactions between filariasis transmission intensity, infection and chronic disease have been limited by a lack of a theoretical framework that allows the explicit examination of mechanisms that may link these variables at the community level. Here, we show how deterministic mathematical models, in conjunction with analyses of standardized field data from communities with varying parasite transmission intensities, can provide a particularly powerful framework for investigating this topic. These models were based on adult worm population dynamics, worm initiated chronic disease and two major forms of acquired immunity (larval- versus adult-worm generated) explicitly linked to community transmission intensity as measured by the Annual Transmission Potential (ATP). They were then fitted to data from low, moderate and moderately high transmission communities from East Africa to determine the mechanistic relationships between transmission, infection and observed filarial morbidity. The results indicate a profound effect of transmission intensity on patent infection and chronic disease, and on the generation and impact of immunity on these variables. For infection, the analysis indicates that in areas of higher parasite transmission, community-specific microfilarial rates may increase proportionately with transmission intensity until moderated by the generation of herd immunity. This supports recent suggestions that acquired immunity in filariasis is transmission driven and may be significant only in areas of high transmission. In East Africa, this transmission threshold is likely to be higher than an ATP of at least 100. A new finding from the analysis of the disease data is that per capita worm pathogenicity could increase with transmission intensity such that the prevalences of both hydrocele and lymphoedema, even without immunopathological involvement, may increase disproportionately with transmission intensity. For lymphoedema, this rise may be further accelerated with the onset of immunopathology. An intriguing finding is that there may be at least two types of immunity operating in filariasis: one implicated in anti-infection immunity and generated by past experience of adult worms, the other involved in immune-mediated pathology and based on cumulative experience of infective larvae. If confirmed, these findings have important implications for the new global initiative to achieve control of this disease.
KHALFAN DRABDALLAHFATMAH. "Abdallah F K , Mwanda W O, .". In: Africa Sanguine . 2006 ; 9;1;1 1-6. The East and Central African Journal of Pharmaceutical Sciences.; 2006. Abstract

OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group.

KHALFAN DRABDALLAHFATMAH. "Abdallah FA .". In: EAMJ , Jan 2008 ; 85 ; 16-21. The East and Central African Journal of Pharmaceutical Sciences.; 2008. Abstract
Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Clematis brachiata Thunberg (Ranunculaceae) is used in Kenya for the management of headaches, malaria and other febrile illnesses, abdominal disorders, yaws and for skin disorders.  Old stems and leaves are chewed for the management of toothaches and sore throats.  Extracts of the plant were subjected to tests for antimalarial, antibacterial and antifungal activity.  The toxicity of the extracts was assessed using the brine shrimp lethality bioassay.   The root extract gave the highest in vitro antimalarial activity against a mulitidrug resistant strain, Plasmodium falciparum VI/S (IC50=39.24 mg/ml). The stem and leaf extracts had insignificant antiplasmodial activity.  The leaf, stem and root extracts had bacterial or fungal growth even at very high concentrations of 10 mg/ml. The LD50 values of the stem and leaf methanol extracts against the brine shrimp larvae was 365.60 and 66.5 mg/ml respectively. The in vitro anti malarial activity of the root extract in part supports the ethnobotanical use of the plant to manage malaria.  KEY WORDS Clematis, Ranunculaceae, antimalarial, brine shrimp, antimicrobial
KHALFAN DRABDALLAHFATMAH. "Abdallah FK. Single dose filgastrim in cytotoxic-induced neutropaenia in children. East Afr Med J. 2008 Jan;85(1):30-5.". In: ast Afr Med J. 2008 Jan;85(1):30-5. The East and Central African Journal of Pharmaceutical Sciences.; 2008. Abstract

OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group.

ABDEL PROFMALEKADELKAMEL. "Abdel Malek AK, Ahmed AM et al. 1990. Prediction of stature from hand measurements. Forensic Sc Internat. 64:181-187. Ireland.". In: Forensic Sc Internat. 64:181-187. Ireland. John Benjamins Publishing Company; 1990. Abstract
A sample of 166 normal adult males and females was taken from different colleges of Assiut representing those living in upper Egypt. Each subject has been studied for measurements of stature (S), hand length (HL) and hand breadth (HB). The data were statistically analysed in order to assess the relationship between stature and hand measurements. The correlation matrix of the study indicates close similarity of the relationship between stature and hand measurements in both sexes and in both sides. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth regardless of sex or side in the form: S = 34.5 + 5.77 HL + 2.7 HB +/- 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement or where there is a chance print of a criminal or an amputated hand or arm.
ABDEL PROFMALEKADELKAMEL. "Abdel Malek AK, Mukherjee D, Roche AF. 1985. A method of constructing an index of obesity. Hum. Biol. 57(3):415-430. USA.". In: Hum. Biol. 57(3):415-430. USA. John Benjamins Publishing Company; 1985. Abstract
A sample of 166 normal adult males and females was taken from different colleges of Assiut representing those living in upper Egypt. Each subject has been studied for measurements of stature (S), hand length (HL) and hand breadth (HB). The data were statistically analysed in order to assess the relationship between stature and hand measurements. The correlation matrix of the study indicates close similarity of the relationship between stature and hand measurements in both sexes and in both sides. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth regardless of sex or side in the form: S = 34.5 + 5.77 HL + 2.7 HB +/- 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement or where there is a chance print of a criminal or an amputated hand or arm.
ABDEL PROFMALEKADELKAMEL. "Abdel Malek AK, Saleh MN, Aly YA, Ahmed MG, Tohamy A. 1995. Brain changes with age on computed tomography. Age & Nutrition. 6(2):93-98. France.". In: Age & Nutrition. 6(2):93-98. France. John Benjamins Publishing Company; 1995. Abstract
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ABDEL PROFMALEKADELKAMEL. "Abdel Malek AK. 1987. Skeletal maturation of boys with Down Syndrome. 5th Ann Conf Fac Med Assiut Univ. Egpyt.". In: 5th Ann Conf Fac Med Assiut Univ. Egpyt. John Benjamins Publishing Company; 1987. Abstract
A sample of 166 normal adult males and females was taken from different colleges of Assiut representing those living in upper Egypt. Each subject has been studied for measurements of stature (S), hand length (HL) and hand breadth (HB). The data were statistically analysed in order to assess the relationship between stature and hand measurements. The correlation matrix of the study indicates close similarity of the relationship between stature and hand measurements in both sexes and in both sides. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth regardless of sex or side in the form: S = 34.5 + 5.77 HL + 2.7 HB +/- 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement or where there is a chance print of a criminal or an amputated hand or arm.
ABDEL PROFMALEKADELKAMEL. "Abdel Malek AK. 1995. Underfed developing Purkinje cell. Age & Nutrition. 6(2):73-78. France.". In: Age & Nutrition. 6(2):73-78. France. John Benjamins Publishing Company; 1995. Abstract
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M. PROFWAEMATIMOTHY. "Abdelnour-Nocera J., Luckin, R., Waema, T. Culture as a bottom up concept to understand diversity in systems production and use.". In: Proceedings of the Fifth Conference on Cultural Attitudes towards Technology and Communication (CATAC), 28 June-1 July 2008, Nimes, France. Pambazuka Press; 2008. Abstract
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P.M. MRWAMBUAPETER. "Abdi,A.I., Wambua P.P., Githui,E.K. and Bulimo, (2007). Deposited 35 P.falciparum ebl-1 gene variants at Gene Bank. Received provisional accession numbers for each gene: EF205091-EF205127.". In: International association of hydrological sciences ( IAHS) publication 2000 No 259. IAHS Press Wallingford, UK.; 2007. Abstract
Although military conflicts are common on the African continent, there is a paucity of data regarding bomb-blast injuries in this region and in Kenya in particular. This paper describes the pattern of maxillofacial injuries sustained after the August 1998 bomb blast that occurred in Nairobi, Kenya. A retrospective cross-sectional study was carried out using hospital-based records of 290 bomb-blast survivors admitted at the Kenyatta National Referral and Teaching Hospital in Nairobi. Using a self-designed form to record information about variables such as the sex and age of the survivors and type of location of soft- and hard-tissue injuries, it was found that of the 290 bomb-blast survivors, 78% had sustained one or more maxillofacial injuries. Soft-tissue injuries (cuts, lacerations or bruises) were the most common, constituting 61.3% of all injuries in the maxillofacial region; 27.6% had severe eye injuries, while 1.4% had fractures in the cranio-facial region. This paper concludes that the effective management of bomb-blast injuries as well as those caused by other types of disaster requires a multidisciplinary approach. The high percentage of maxillofacial injuries confirm that maxillofacial surgeons should form an integral part of this multidisciplinary team.
P.M. MRWAMBUAPETER. "Abdi,A.I., Wambua P.P., Githui,E.K. and Bulimo, W.D. Nucleotide polymorphism in reqion I of the P.falciparum ebl-1 gene in field isolated obtained form various regions of Kenya (2007) in press.". In: International association of hydrological sciences ( IAHS) publication 2000 No 259. IAHS Press Wallingford, UK.; 2007. Abstract
Although military conflicts are common on the African continent, there is a paucity of data regarding bomb-blast injuries in this region and in Kenya in particular. This paper describes the pattern of maxillofacial injuries sustained after the August 1998 bomb blast that occurred in Nairobi, Kenya. A retrospective cross-sectional study was carried out using hospital-based records of 290 bomb-blast survivors admitted at the Kenyatta National Referral and Teaching Hospital in Nairobi. Using a self-designed form to record information about variables such as the sex and age of the survivors and type of location of soft- and hard-tissue injuries, it was found that of the 290 bomb-blast survivors, 78% had sustained one or more maxillofacial injuries. Soft-tissue injuries (cuts, lacerations or bruises) were the most common, constituting 61.3% of all injuries in the maxillofacial region; 27.6% had severe eye injuries, while 1.4% had fractures in the cranio-facial region. This paper concludes that the effective management of bomb-blast injuries as well as those caused by other types of disaster requires a multidisciplinary approach. The high percentage of maxillofacial injuries confirm that maxillofacial surgeons should form an integral part of this multidisciplinary team.
KD O, L O. "Abdominal cocoon: A Case Report." Annals of African Surgery. 2009;4(1):36-38.
Ongeti KW. "Abdominal Tuberculosis Mimicking Annular Pancreas in an Adult .". 2012. AbstractWebsite

Gastrointestinal tuberculosis is rampant in Africa and can mimic other gastrointestinal diseases. Isolated duodenal involvement is rare. We report a patient who succumbed to an isolated mid duodenal tuberculosis whose clinical presentation, endoscopy and computerised tomography scans resembled annular pancreas, only to be diagnosed at laparotomy. The limitations of clinical evaluation, endoscopy and radiology are highlighted as the importance of diagnostic laparoscopy is emphasized.

A DROBONDOANNE, M PROFNDETEIDAVID, MAINA DRMBURUJOHN. "Abdulreshid A. B, Ndetei D.M, Mburu J.M, Obondo A.A, Kokonya D,.". In: In Eds. Ndetei et al (2006). International Psychiatry Vol.6 No. 1; 2006.
A DROBONDOANNE, M PROFNDETEIDAVID, MAINA DRMBURUJOHN. "Abdulreshid A. B, Ndetei D.M, Mburu J.M, Obondo A.A, Kokonya D,.". In: In Eds. Ndetei et al (2006). CHAK Times; 2006. Abstract
Mice infected with Trypanosoma congolense developed a severe anaemia 1 week after infection, which persisted till treatment with diminazine aceturate when the packed cell volume (PCV) recovered to pre-infection levels. This was accompanied by a marked increase in the plasma levels of the acute phase proteins (APP), serum amyloid P-component (SAP) and haptoglobin (Hp). The initial peak levels of Hp and SAP were attained 7 and 12 days post-infection (DPI), respectively. Thereafter SAP levels decreased significantly to near pre-infection levels, but later increased even after treatment to give a second peak 34 DPI after which there was a decline till the study was terminated. The Hp levels on the other hand decreased to an intermediate level after the initial peak increasing to a second peak 22 DPI. Thereafter Hp decreased significantly following diminazine aceturate treatment to reach pre-infection levels within 5 days post-treatment. This indicates that T. congolense-infected mice develop severe anaemia accompanied by an acute phase response leading to an increase in SAP and Hp but that following treatment divergent responses occurred indicating differences in the pathways for stimulation of the APP. Haptoglobin was shown to be an earlier indicator of infection and a better marker in monitoring the response to treatment.
MBURU DRJOHNIRUNGU. "Abebaw D., K. Holm-M.". In: Quarterly Journal of International Agriculture, 45, No. 3: 253-268. Ogutu J.O; 2006. Abstract
The vision of the Government of Kenya is to facilitate ICT as a universal tool for education and training. In order to achieve this vision every educational institution, teacher, learner and the respective community should be equipped with appropriate ICT infrastructure, competencies and policies for usage and progress. It calls for recognition of the fact that ICT provides capabilities and skills needed for a knowledge-based economy. It also calls for transforming teaching and learning to incorporate new pedagogies that are appropriate for the 21st  century. The Ministry of Education�s (MOE) mission is to facilitate effective use of ICT to improve access, learning and administration in delivery education programmes and services. The principal objective will be to integrate ICT in the delivery of education and training curricula. XML:NAMESPACE PREFIX = O />  Although not exhaustive, the range of ICT that have been used in the delivery of education to improve access, teaching, learning, and administration includes: Electric Board, Audio Cassette, Radio for Interactive Radio Instructions (IRI), Video/TV-Learning, Computer, Integrated ICT infrastructure and Support Application Systems (SAS).These systems are in use, at various degrees, in most parts of Africa (Charp, 1998). This plan envisages use ofthese digital components to improve access and quality in the delivery of education in Kenya.  The major challenge in respect to this component is limited digital equipment at virtually all levels of education. While the average access rate is one computer to 15 students in most of the developed countries, the access rate in Kenya is approximately one computer to 150 students (EMIS, 2005). Whereas most secondary schools in Kenya have some computer equipment, only a small fraction is equipped with basic ICT infrastructure. In most cases equipment of schools with ICT infrastructure has been through initiatives supported by the parents, government, development agencies and the private sector, including the NEPAD E-Schools programme. Attempts to set up basic ICT infrastructure in primary schools are almost negligible.  According to ICTs in Education Options Paper, one of the main problems is limited penetration of the physical telecommunication infrastructure into rural and low-income areas. Specifically, the main challenge is limited access to dedicated phone lines and high-speed systems or connectivity to access e-mail and Internet resources. The EMIS Survey (2003/2004) indicated that over 70% of secondary schools and a much larger proportion of primary schools require functional telephones. Indeed, many parts of Kenya cannot easily get Internet services because of the poor telephone networks. About 90% of secondary schools need to establish standard Local Area Networks (LANs) in order to improve sharing of learning resources.  Alternative and appropriate technologies for access to Internet resources, including wireless systems remain quite expensive. Indeed, a small proportion of schools have direct access, through Internet Service Providers (ISPs), to high-speed data and communication systems. Furthermore, very few schools in the rural areas use wireless technology such as VSAT to access e-mail and Internet resources. Nearly all of the 6 NEPAD e-Schools are in rural areas and are expected to enjoy internet connectivity through VSAT technology.  While other countries have reported up to 41% of integration of ICT to teaching and learning, the proportion remains substantially low in Africa, Kenya included. Integration aims at the use ICT to support teaching and learning in the delivery of the various curricula to achieve improved education outcomes. Because ICT is interactive media, it facilitates students to develop diversified skills needed for industrialization and a knowledge-based economy. It also allows teachers and learners to proceed at different paces depending on the prevailing circumstances. As a first step, the Ministry of Education has initiated a major ICT project in Secondary schools meant to equip over 200 secondary schools with ICT infrastructure for integration of ICT in teaching/learning process ( KESSP, 2004). Three schools have been chosen in every district of Kenya.
D.K O, J.W. G. "An aberrant uterus: A case report." East African Medical Journal. 2015:1-4.
MITEMA PROFSEO. "The ability of phenylbutazone and dexamethasone to modulate postoperative phenomena in cattle. Ken Vet J. 28: 29 32.". In: 4rd YES Summit at KICC, Nairobi - Kenya. BEP Electronic Press; 2005.
PROF. MBITHI PMF. "The ability of Phenylbutazone and dexamethazone to modulate postoperative phenomena in cattle. Kenya Veterinarian Vol. 28 pp. 29-32.". In: 4th TICH Annual Scientific Conference Kisumu, Kenya. AWC and FES; 2005. Abstract

The ability of Phenylbutazone and Dexamethazone to modulate post operative tempetature, limping, joint pain and joint mobility after joint surgery in calves was assessed. Intramuscular injections of 4.4mg/kg Phenylbutazone or 0.2 mg/kg Dexamethazone were given to two groups of calves. Both Dexamethazone and Phenybutazone were effective in reducing pain, limping and fever with a tendency fo Dexamethazone to be more potent than Phenylbutazone. However there was no significant difference between the ability of Dexamethazone and Phenylbitazone to module these controlled use of the anti-inflammatory drugs in the immediate post-operative period in cattle in beneficial.

Ngeranwa JJ. "The ability of Stomoxys calcitrans and mechanical means to transmitTrypanosoma (brucei) evansi from goats to camels in Kenya.". 1994. Abstract

Stomoxys calcitrans failed to transmitTrypanosoma (b.) evansi from infected goats to other goats or camels, but the trypanosomal infection was transmitted by needle prick from infected goats to camels.

ONDOH MRNYABOLALAMBERT. "Abinya N.A.O., Nyabola L.O, Abwao, B.O, Ndege P. Postsurgical Management of Patients with Breast Cancer at Kenyatta hospital.EastAfrican Medical Journal, 2002, 79:156 - 162.". In: EastAfrican Medical Journal, 2002, 79:156 - 162. UoN; 2002. Abstract
OBJECTIVE: To assess post-surgical management of patients with breast cancer at the Kenyatta National Hospital. DESIGN: Retrospective analysis of patients treated for breast carcinoma at Kenyatta National Hospital between January 1989 and January 2000. SETTING: Kenyatta National Hospital. SUBJECTS: Three hundred and seventy-four patients who had surgery or biopsy for breast cancer at the Kenyatta National Hospital. INTERVENTION: Chemo-hormonal therapy and/or radiotherapy for adjuvant, metastatic, or palliative purposes. RESULTS: Twenty-two patients received adjuvant chemotherapy, and 21 patients received chemotherapy for metastatic disease. Forty-six patients received adjuvant radiotherapy and 53 had radiotherapy for palliative purposes. One hundred and twenty-six patients were given tamoxifen for adjuvant and metastatic purposes. The median duration of follow-up was 20 months. CONCLUSION: Chemotherapy is grossly underutilized in the treatment of breast cancer at the Kenyatta National Hospital, and radiotherapy is also underutilized. Follow-up durations are dismal and if this is used as a surrogate measure for survival then survival durations for breast cancer patients are also dismal at the Kenyatta National Hospital.
ONDOH MRNYABOLALAMBERT. "Abinya N.A.O., Nyabola L.O. Experience with Vincristine-associated neurotoxicity.East African Medical Journal 2001; 78:376.". In: East African Medical Journal 2001; 78:376. UoN; 2001. Abstract
OBJECTIVES: To evaluate the frequency and severity of occurrence of vincristine-associated neurotoxicity. DESIGN: A retrospective case series study. SETTING: Hurlingham Oncology Clinic, Nairobi. SUBJECTS: Thirty-eight patients treated for various neoplasms with vincristine containing chemotherapeutic regimens. MAIN OUTCOME MEASURES: The frequency and degree of neurotoxicity when vincristine was given at the standard dose of 1.4 mg/m2. RESULTS: Five patients (13.2%) developed peripheral neuropathy, one having had it even before vincristine was started. Therefore only four (10.5%) had it attributed to vincristine. Four of the patients who developed neuropathy (80%) were HIV-positive. Neuropathy grade 2 (severe) occurred in only two patients leading to discontinuation of the drug. All the neurotoxicity resolved after discontinuation of vincristine. CONCLUSION: Vincristine induced neuropathy occurred but was rarely severe at a dose of 1.4 mg/m2. It appeared to be more frequent in HIV infected individuals, but controlled studies with bigger sample sizes are required to determine whether this may warrant routine capping of the dose at a maximum of 2 mg.
ONDOH MRNYABOLALAMBERT. "Abinya N.A.O., Nyabola L.O. Nadir Neutrophil counts in patients treated for breast cancer with doxorubicin and cystophosphoride. East Afrina Medical Journal, 2001;78:370.". In: East Afrina Medical Journal, 2001; 78:370. UoN; 2001. Abstract
OBJECTIVE: To determine the impact on neutrophils if adriamycin is administered at 60 mg/m2 and cyclophosphamide at 600/m2 (AC 60/600); and at 50 mg/m2 and 500 mg/m2 (50/500) in the treatment of breast cancer. DESIGN: Restrospective analysis of nadir neutrophil counts in female mammary carcinoma patients treated with adriamycin/cyclophosphamide combination. SETTING: Hurlingham Oncology Clinic, Nairobi and The Nairobi Hospital between March 1995 and August 1999. SUBJECTS: Eighteen patients with breast cancer were treated either for adjuvant purposes or for metastatic disease. INTERVENTION: Chemotherapy with adriamycin and cyclophosphamide at 60/600 or 50/500. Patients were advised to avoid crowded places and given prophylactic broadspectrum antibiotics whenever grade 4 neutropenia occurred at nadir. RESULTS: Grade 3-4 neutropenia occurred in 75.5% of treatments at 60/600 and in 56.8% of the treatments at 50/500. Febrile neutropenia followed only one treatment and did not result in death. CONCLUSION: Neutropenia is frequent and severe at A/C 60/600 and need to be watched out for. Sepsis on the other hand is prevented if meticulous attention is given and corrective measures taken. A/C 50/500 was associated with less occurrences of neutropenia though still very high. Neutropenia should therefore be checked and steps be taken to prevent sepsis even at this dosage.

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