Kamau F,N. I.O.Kibwage, Muriuki G, Guantai A.N., Hoog martens J, Roets E, Govaerts, C; Chepkwony. H. and Busson R.Estrogenic and Anti-inflamatory activity of a steroidal. Idoxyl, The East and Central Journal of Pharmaceutical Sciences Vol. 5 (3) 44-48 Dec

Citation:
N PROFGUANTAIA. "Kamau F,N. I.O.Kibwage, Muriuki G, Guantai A.N., Hoog martens J, Roets E, Govaerts, C; Chepkwony. H. and Busson R.Estrogenic and Anti-inflamatory activity of a steroidal. Idoxyl, The East and Central Journal of Pharmaceutical Sciences Vol. 5 (3) 44-48 Dec.". In: The East and Central Journal of Pharmaceutical Sciences Vol. 5 (3) 44-48 Dec 2002. F. N. KAMAU., 1.0. KIBWAGE, A. N. GUANTAI, G. MURIUKI R. MUNENGE; 2002.

Abstract:

The anti-inflammatory and antidiarrhoeal activities of 3(1-Hydroxy-16. 17-seco-16- nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg using the carrageenan induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED50 of 5.8 mg/kg in this assay. Compound (I) and indomethacin caused comparable and dose-dependent varying degrees of delay in diarrhoea and also significantly reduced net colonic water flux into the colon of rats induced by castor oil. Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.

Notes:

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