Guantai A.N and Addae-Mensah I.Chloroquine Drug Interactions Part 1I. Interactions with diuretics. East and Central African Journal of Pharmaceutical Sciences Vol (3. No.3, 31-35 (2000).

Citation:
N PROFGUANTAIA. "Guantai A.N and Addae-Mensah I.Chloroquine Drug Interactions Part 1I. Interactions with diuretics. East and Central African Journal of Pharmaceutical Sciences Vol (3. No.3, 31-35 (2000).". In: East and Central African Journal of Pharmaceutical Sciences Vol (3. No.3, 31-35 (2000). F.A. OKALEBO*, H.A. RABAHI, A.N. GUANTAII, C.K. MALTA', I.0. K1BWAGE, J.W. MWANGI AND W. MASENGO; 2000.

Abstract:

The in vitro antimalarial activity of the root extract in partly supports the ethnobotanical use of the plant to manage malaria. Clematis brachiata Thunberg (Ranunculaceae) is used in Kenya for the management of headaches, malaria and other febrile illnesses, abdominal disorders, yaws and for skin disorders. Old stems and leaves are chewed for the management of toothaches and sore throats. Extracts of the plant were subjected to tests for antimalarial, antibacterial and antifungal activity. The toxicity of the extracts was assessed using the brine shrimp lethality bioassay. The root extract gave the highest in vitro antimalarial activity against the inulitidrug resistant strain, Plasmodium falciparum VI/S (IC50=39.24 jig/nil). The stem and leaf extracts had insignificant antiplasmodial activity. The leaf, stein and root extracts had no bacterial or fungal inhibitory effects even at very high concentrations of 10 mg/ml. The Lll50 values of the stem and leaf methanol extracts against the brine shrimp larvae was 365.60 and 66.5 jig/ml, respectively. Key Words: Clematis brachiata, Ranuneulaceae, antimalarial, antibacterial, antifungal, brine shrimp.

Notes:

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