Effects of the active constituents of Catha edulis on the neuromuscular junction.Guantai AN, Mwangi JW, Muriuki G, Kuria KA. Neuropharmacology. 1987 May;26(5):401-5.

Citation:
N PROFGUANTAIA. "Effects of the active constituents of Catha edulis on the neuromuscular junction.Guantai AN, Mwangi JW, Muriuki G, Kuria KA. Neuropharmacology. 1987 May;26(5):401-5.". In: Neuropharmacology. 1987 May;26(5):401-5. Ivan Addae-Mensah,t Rahab Munenge and Anastasia N. Guantai; 1987.

Abstract:

(-)-Cathinone and d-norpseudoephedrine (DNE) in the dose range 0.2-1.2 mg/ml produced a reduction in contractions of skeletal muscle, evoked by direct and indirect electrical stimulation and antagonised the facilitatory action of physostigmine on the neuromuscular junction; but failed to antagonise a partial blockade induced by d-tubocurarine (dTb) as occurs with norepinephrine or epinephrine. The local anaesthetic actions of (-)-cathinone and DNE were found to be almost equivalent to that of lignocaine. These results indicate that (-)-cathinone and DNE may have a direct blocking action on the neuromuscular junction, which is independent of cholinergic and adrenergic transmission.

Notes:

n/a

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