Comparative Examination of Two Zanthoxylum Benzophenanthridine Alkaloids for Cardiovascular Effects in Rabbits

Citation:
N PROFGUANTAIA. "Comparative Examination of Two Zanthoxylum Benzophenanthridine Alkaloids for Cardiovascular Effects in Rabbits.". In: EAST AND CENTRAL AFRICAN JOURNAL OF PHARMACEUTICAL SCIENCES - VOL. 1. Ivan Addae-Mensah,t Rahab Munenge and Anastasia N. Guantai; 1989.

Abstract:

Cardiovascular activities of nitidine chloride from Zanthoxylunt chalybeum have been compared with those of 9-methoxychelerythrine. Whereas nitidinc chloride was found to show significant hypotensive activity in rabbits, 9-methoxychelerythrine chloride showed no hypotensive activity. The effect of nitidine chloride on isolated rabbit heart was also compared with those of adrenaline and acetylcholine. 9-Methoxychelerythrine, which has hitherto been regarded as an artefact formed by recrystallization of chelerythrine base from methanol, has been shown in this work to be a true natural constituent of Zanthoxylum chalybeum. Keywords: 9-inethoxychelerythrine; nitidine chloride; cardiovascular properties; hypotensive effect; Zanthoxylum chalybeum.

Notes:

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