Anti-infiammatory and Anti-Diarrimeai Activities of a Steroidal indoxy

N PROFGUANTAIA. "Anti-infiammatory and Anti-Diarrimeai Activities of a Steroidal indoxy.". In: East and Central African Journal of Pharmaceutical Sciences 6. F. N. KAMAU., 1.0. KIBWAGE, A. N. GUANTAI, G. MURIUKI R. MUNENGE; 2003.


The anti-inflammatory and antidiarrhoeal activities of 3(1-Hydroxy-16. 17-seco-16- nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg using the carrageenan induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED50 of 5.8 mg/kg in this assay. Compound (I) and indomethacin caused comparable and dose-dependent varying degrees of delay in diarrhoea and also significantly reduced net colonic water flux into the colon of rats induced by castor oil. Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.




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