DR. NDAKALA ALBERT
BSc (UoN), MSc (UoN), Ph.D (University of Connecticut)
Physical Address: Department of Chemistry B-6, Faculty of Science and Technology, Email address: andakala@uonbi.ac.ke
Physical Address: Department of Chemistry B-6, Faculty of Science and Technology, Email address: andakala@uonbi.ac.ke
Description
Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2),(E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5–11), were isolated from the CH 2 Cl 2/MeOH (1: 1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC 50 1.7±0.1 μM, with relatively low cytotoxicity, IC 50> 21 μM, against four cell-lines. View Full-Text