Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

Citation:
Atilaw Y, Muiva-Mutisya L, Ndakala A, Akala HM, Yeda R, Wu YJ, Coghi P, Wong VKW, Erdélyi Máté, Yenesew A. "Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya." Molecules. 2017;22(9):1514.

Abstract:

Description
Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2),(E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5–11), were isolated from the CH 2 Cl 2/MeOH (1: 1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC 50 1.7±0.1 μM, with relatively low cytotoxicity, IC 50> 21 μM, against four cell-lines. View Full-Text

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