Human immunodeficiency virus in urethral secretions in men:Associations with gonococcal urethritis and CD4 depletion.Moss GB, Overbaugh J, Welch M, Relly M, Bwayo J.J, Plummer FA, Ndinya-Achola JO, Melisa MA, Kreiss JK. Journal of Infectious Disease 1995;

Citation:
JOAB PROFBWAYOJOB. "Human immunodeficiency virus in urethral secretions in men:Associations with gonococcal urethritis and CD4 depletion.Moss GB, Overbaugh J, Welch M, Relly M, Bwayo J.J, Plummer FA, Ndinya-Achola JO, Melisa MA, Kreiss JK. Journal of Infectious Disease 1995;.". In: Journal of Infectious Disease 1995;172:1469-74. Asian Economic and Social Society; 1995.

Abstract:

The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status and infection with HIV-1 among men with genital ulcer disease. Eight hundred and ten men participated in the study, of whom 190 (23%) were HIV-1-positive. A logistic regression model adjusted for behavioral and historical showed that HIV-1 positivity was independently associated with being uncircumcised (adjusted odds ratio [OR], 4.8; 95% confidence interval [CI], 3.3-7.2) and with a history of urethral discharge (adjusted OR, 2.0; 95% CI, 1.4-2.8). This association could not be explained by measures of sexual exposure to HIV-1 among this population. Male circumcision should be considered as an intervention strategy for AIDS control.

Notes:

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